Yiqiang Cai, PhD, MD

Associate Research Scientist in Medicine (Nephrology)

Research Interests

Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Diseases

Research Organizations

Internal Medicine: Nephrology

Extensive Research Description

My current research is focused on the study of molecular basis of ADPKD pathogenesis. By establishing cell-based model and BAC-transgenic mouse model, we are trying to answer the following questions: 1) How are polycystin-1 and polycystin-2 trafficking to cilia regulated; 2) What is the consequence that trafficking defect of the polycystins cause in the cystogenesis/PKD pathogenesis; 3) What is the molecular basis underlying the mutations of PKD1 and PKD2 genes, 4) How is the polycystin-2 phosphorylation regulated, and 5) What is the role that regulation of polycystin-2 phosphorylation plays on the PKD pathogenesis.

Selected Publications

  • A polycystin-centric view of cyst formation and disease: the polycystins revisited. ACM Ong, PC Harris - Kidney international, 2015 - nature.com ABSTRACT It is 20 years since the identification of PKD1, the major gene mutated in autosomal dominant polycystic kidney disease (ADPKD), followed closely by the cloning of PKD2. These major breakthroughs have led in turn to a period of intense investigation into ...
  • Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity K Hopp, CJ Ward, CJ Hommerding… - The Journal of clinical …, 2012 - ncbi.nlm.nih.gov Abstract Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations to PKD1 or PKD2, triggering progressive cystogenesis and typically leading to end-stage renal disease in midlife. The phenotypic spectrum, however, ranges from in utero onset to ...
  • Effect of cytochrome P450 polymorphism on arachidonic acid metabolism and their impact on cardiovascular diseases BNM Zordoky, AOS El-Kadi - Pharmacology & therapeutics, 2010 - Elsevier Cardiovascular diseases (CVDs) remain the leading cause of death in the developed countries. Taking into account the mounting evidence about the role of cytochrome P450 (CYP) enzymes in cardiovascular physiology, CYP polymorphisms can be considered one ...
  • The RCC1 superfamily: from genes, to function, to disease O Hadjebi, E Casas-Terradellas… - … et Biophysica Acta (BBA …, 2008 - Elsevier The Regulator of Chromosome Condensation 1 (RCC1) was identified over 20 years ago as a critical cell cycle regulator. By analyzing its amino acid sequence, RCC1 was found to consist of seven homologous repeats of 51–68 amino acid residues, which were later ...
  • Autosomal dominant polycystic kidney disease VE Torres, PC Harris, Y Pirson - The Lancet, 2007 - Elsevier Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal, monogenic disorder. It is associated with large interfamilial and intrafamilial variability, which can be explained to a large extent by its genetic heterogeneity and modifier genes. An ...
  • TRP channels: an overview SF Pedersen, G Owsianik, B Nilius - Cell calcium, 2005 - Elsevier The TRP (“transient receptor potential”) family of ion channels now comprises more than 30 cation channels, most of which are permeable for Ca2+, and some also for Mg2+. On the basis of sequence homology, the TRP family can be divided in seven main subfamilies: ...
  • Calcium signalling: dynamics, homeostasis and remodelling MJ Berridge, MD Bootman, HL Roderick - Nature reviews Molecular …, 2003 - nature.com Abstract Ca 2+ is a highly versatile intracellular signal that operates over a wide temporal range to regulate many different cellular processes. An extensive Ca 2+-signalling toolkit is used to assemble signalling systems with very different spatial and temporal dynamics. ...
  • Transient receptor potential cation channels in disease B Nilius, G Owsianik, T Voets… - Physiological …, 2007 - Am Physiological Soc Abstract The transient receptor potential (TRP) superfamily consists of a large number of cation channels that are mostly permeable to both monovalent and divalent cations. The 28 mammalian TRP channels can be subdivided into six main subfamilies: the TRPC ( ...
  • Calcium signalling: dynamics, homeostasis and remodelling MJ Berridge, MD Bootman, HL Roderick - Nature reviews Molecular …, 2003 - nature.com Abstract Ca 2+ is a highly versatile intracellular signal that operates over a wide temporal range to regulate many different cellular processes. An extensive Ca 2+-signalling toolkit is used to assemble signalling systems with very different spatial and temporal dynamics. ...
  • Polycystin-2 is an intracellular calcium release channel P Koulen, Y Cai, L Geng, Y Maeda, S Nishimura… - Nature cell …, 2002 - nature.com Abstract Polycystin-2, the product of the gene mutated in type 2 autosomal dominant polycystic kidney disease (ADPKD), is the prototypical member of a subfamily of the transient receptor potential (TRP) channel superfamily, which is expressed abundantly in ...
  • TRP channels as cellular sensors DE Clapham - Nature, 2003 - nature.com Abstract TRP channels are the vanguard of our sensory systems, responding to temperature, touch, pain, osmolarity, pheromones, taste and other stimuli. But their role is much broader than classical sensory transduction. They are an ancient sensory apparatus for the cell, ...
  • Transient receptor potential cation channels in disease B Nilius, G Owsianik, T Voets… - Physiological …, 2007 - Am Physiological Soc Abstract The transient receptor potential (TRP) superfamily consists of a large number of cation channels that are mostly permeable to both monovalent and divalent cations. The 28 mammalian TRP channels can be subdivided into six main subfamilies: the TRPC ( ...
  • The ciliopathies: an emerging class of human genetic disorders JL Badano, N Mitsuma, PL Beales… - Annu. Rev. Genomics …, 2006 - annualreviews.org Abstract Cilia and flagella are ancient, evolutionarily conserved organelles that project from cell surfaces to perform diverse biological roles, including whole-cell locomotion; movement of fluid; chemo-, mechano-, and photosensation; and sexual reproduction. Consistent with ...

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Contact Info

Yiqiang Cai, PhD, MD
Mailing Address
Internal MedicinePO Box 208056
333 Cedar Street

New Haven, CT 06520-8056