Yiqiang Cai, MD, PhD

Associate Research Scientist in Medicine (Nephrology)

Research Interests

Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Diseases

Research Organizations

Internal Medicine

Extensive Research Description

My current research is focused on the study of molecular basis of ADPKD pathogenesis. By establishing cell-based model and BAC-transgenic mouse model, we are trying to answer the following questions: 1) How are polycystin-1 and polycystin-2 trafficking to cilia regulated; 2) What is the consequence that trafficking defect of the polycystins cause in the cystogenesis/PKD pathogenesis; 3) What is the molecular basis underlying the mutations of PKD1 and PKD2 genes, 4) How is the polycystin-2 phosphorylation regulated, and 5) What is the role that regulation of polycystin-2 phosphorylation plays on the PKD pathogenesis.

Selected Publications

  • Publications (selected from total 44) 1) Yiqiang Cai, SV Fedeles, K Dong, et al: Altered trafficking and stability of polycystins underlie polycystic kidney disease. J Clinical Investigation, Epub 2014 Nov 3. 2) Fedeles SV, Tian X, Gallagher AR, Mitobe M,

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Contact Info

Yiqiang Cai, MD, PhD
Mailing Address
Internal MedicinePO Box 208056
333 Cedar Street

New Haven, CT 06520-8056