Arthropod Vectors; Borrelia; Lyme Disease; Ticks; Global Health; Infectious Disease Medicine
Sukanya Narasimhan is a research scientist of infectious diseases in the department of internal medicine at Yale University School of Medicine. Her research focuses on arthropod vector-host-pathogen interactions and arthropod vector gut microflora and host skin microflora in the context of pathogen transmission. Dr. Narasimhan studies how pathogen infection levels are sustained on the molecular level in arthropod vectors and what factors determine infection rates in endemic areas, with an aim to control vector-borne diseases. Her current research interests are the tick-Borrelia interactions and Lyme disease. Dr. Narasimhan is a recipient of the inaugural travel grant from the Yale Global Health Initiative.
Dr. Narasimhan received her M.Sc. from Central College and her Ph.D. from the Indian Institute of Science in Bangalore, India. She was a postdoctoral research associate of internal medicine, molecular biophysics and biochemistry at the Yale University School of Medicine. Dr. Narasimhan served on the board of editors of the Journal of Eukaryotic Microbiology.
Specialized Terms: Tick-Borrelia interactions
Gut microbiota of the tick vector Ixodes scapularis modulate colonization of the Lyme disease spirochete.
Gut microbiota of the tick vector Ixodes scapularis modulate colonization of the Lyme disease spirochete. Narasimhan S, Rajeevan N, Liu L, Zhao YO, Heisig J, Pan J, Eppler-Epstein R, Deponte K, Fish D, Fikrig E. Cell Host Microbe. 2014 Jan 15;15(1):58-71. doi: 10.1016/j.chom.2013.12.001.
A tick gut protein with fibronectin III domains aids Borrelia burgdorferi congregation to the gut during transmission.
A tick gut protein with fibronectin III domains aids Borrelia burgdorferi congregation to the gut during transmission. Narasimhan S, Coumou J, Schuijt TJ, Boder E, Hovius JW, Fikrig E. PLoS Pathog. 2014 Aug 7;10(8):e1004278. doi: 10.1371/journal.ppat.1004278. eCollection 2014 Aug.
A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent
Schuijt, T.J., J. Coumou, S. Narasimhan, J. Dai, K. Deponte, D. Wouters, M. Brouwer, A. Oei, J.J. Roelofs, A.P. van Dam, T. van der Poll, C. Van't Veer, J.W. Hovius, and E. Fikrig. 2011. A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent. Cell Host Microbe 10:136-146. 3170916