Mark David Siegel MD

Professor of Medicine (Pulmonary); Co-Chair, Ethics Committee, Yale-New Haven Hospital; Program Director, Traditional Internal Medicine Residency

Research Interests

Sepsis and ARDS treatments; Chronic illness; Ethics; End-of-life decision making

Current Projects

I am also working on a project to determine the degree to which concerns about long-term dependence on life support influence patients' wishes regarding life sustaining interventions.

I am also engaged in a project focusing on the factors that drive clinicians to provide clinically ineffective interventions in the ICU.


Research Summary

Dr. Mark Siegel, the Program Director of the Traditional Internal Medicine Residency, is involved in multiple clinical research studies. For several years he has participated in multicenter clinical research trials investigating new treatments for sepsis and acute respiratory distress syndrome (ARDS), in addition to other facets of critical illness. Dr. Siegel has several ongoing research projects conducted with Yale trainees, in areas such as the management of sepsis, end-of-life decision making, and psychiatric disorders in the next-of-kin of ICU patients.

Extensive Research Description

I am interested in studying the factors that influence end-of-life decision making by ICU clinicians and the family members of critically ill patients. In conjunction with this I am interested in the emotional, religious, educational, and cognitive factors that influence how choices are made.

I also maintain a strong focus on new treatment strategies for ARDS and sepsis as well as a striving for a better understanding of the factors that underlie the pathogenesis and outcomes of critical illness.


Selected Publications

  • Azoulay E, Siegel MD. Self-Efficacy Approaches to Improving End-Of-Life Care for the Critically Ill: ineffective, insufficient or inconclusive? Am J Respir Crit Care Med 2011;183 288-290.
  • Marotta SE, Belchikov Y, Siegel MD. Hypothermia and Protection from Acetaminophen Induced Liver Injury. Ther Hypothermia Temp Management 2011; 1:57-60.
  • Sauler M, Siegel MD. The Past, Present, and Future of Advance Directives as a Guide to End-of-Life Decision Making. Chest 2012; 141:9-10.
  • Siegel MD, Perez MT. Within the Black Box: Exploring How Intensivists Resolve Conflict at the End-of-Life. Crit Care Med 2012; 40:1339-40
  • Siegel, MD. Do You See What I See? Families, Physicians, and Prognostic Dissonance in the ICU. Crit Care Med. 2010; 38:1381-1382
  • Mannam P, Siegel MD. Management of Life-Threatening Asthma in Adults. J Int Care Med 2010; 25:3-15
  • Siegel MD, Prigerson HG. The Perception Gap: Race, Religion and Prognosis in the ICU. Chest 2010; 138:8-9
  • Honiden S, Siegel MD. Management of the Agitated Patient in the ICU: Sedation, Analgesia, and Neuromuscular Blockade. J Int Care Med. 2010; 25:187-204
  • Siegel MD, Rubinowitz AN. Routine daily vs on-demand chest radiographs in intensive care. The Lancet. 2009; 374:1656-1658
  • Siner JM, Bhandari V, Engle KM, Elias JA, Siegel MD. Elevated Serum Angiopoietin-2 Levels are Associated with Increased Mortality in Sepsis. Shock. 2009; 31:348-353

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