Jun Yu MD
Senior Research Scientist in Medicine (Cardiology)
Vascular Remodeling, Atherosclerosis, Angiogenesis/Arteriogenesis, Signaling Transduction
a. To study the role of Reticulon-4B (Nogo-B) in macrophage biology and atherosclerotic plaque progression.
b. To understand the role of primary ciliary localized protein, polycystins -1 and -2, in hypertension and shear stress induced inflammatory responses.
c. To study the role of Nogo-B in pulmonary arterial hypertension.
The primary research goals in my laboratory are to understand the molecular control of vascular remodelling and angiogenesis/arteriogenesis in response to arterial injury, atherosclerosis and ischemia. We have intensively used mouse genetic, cell biological and biochemical approaches to achieve these goals.
- Liu R, Jin Y, Tang W, Qin L, Zhang X, Tellides G, Hwa J, Yu J, Martin KA. TET2 is a master regulator of smooth muscle cell plasticity. Circulation. 2013 Sep 27. [Epub ahead of print]
- Yu J*, Zhang Y, Zhang X, Rudic RD, Bauer PM, Altieri DC, Sessa WC. Endogenous endothelial derived nitric oxide negatively regulates the PDGF-survivin pathway during flow-dependent vascular remodeling. PLoS ONE. 2012; 7(2):e31495. PMCID: PMC3280303 (*corresponding author)
- Yu J, Fernández-Hernando C, Suarez Y, Schleicher M, Hao Z, Wright PL, Kyriakides TR, Sessa WC. Reticulon 4B (Nogo-B) is critical for macrophage dependent inflammatory tissue repair. Proc Natl Acad Sci U S A. 2009; 106(41):17511-6. PMCID: PMC2762666
- Yu J, Bergaya S, Murata T, Alp IF, Bauer MP, Lin MI, Drab M, Kurzchalia TV, Stan RV, Sessa WC. Direct evidence for the role of caveolin-1 and caveolae in mechanotransduction and remodeling of blood vessels. J Clin Invest. 2006; 116(5):1284-1291. PMCID: PMC1451207
- Yu J, Acevedo L, (equal contribution) Erdjument-Bromage H, Miao RQ, Kim JE, Fulton D, Tempst P, Strittmatter, SM, Sessa WC. A new role for Nogo as a regulator of vascular remodeling. Nat Med. 2004; 10(4): 382-8.