Jose Luis Gomez Villalobos MD, MS
Instructor in Medicine (Pulmonary)
Validation of a genetic signature in the airway of asthmatics exposed to second-hand smoke.
My research focuses on the impact of second-hand smoke in the biology of asthma. Cigarette smoke is a strong environmental influence with a negative effect in lung function and asthma. A better understanding of the interaction between second-hand smoke and asthma has the potential to modify asthma therapies and support the efforts for environmental control and respiratory health.
Extensive Research Description
The alveolar macrophage plays a critical role in response to noxious environmental stimuli and maintenance of gas exchange in the lung. Cigarette smoke disrupts that balance through exposure to inhaled xenobiotic particles, free radical production and immune activation. The alveolar macrophage response to the smoking challenge represents a continuum that ultimately leads to permanent lung function impairment. Secondhand smoke (SHS) is a recognized trigger of asthma exacerbations. However, the behavior of the alveolar macrophage from asthmatics after SHS exposure is only partially known.
Our current project is focused on the characterization of the molecular response to SHS in airway macrophages of asthmatics.
My laboratory is also interested in the integration of high-throughput data generated in our laboratory and publicly accessible data to understand the biology of airways disease and the fundamental molecular processes present across pulmonary disease in general.