Jose Luis Gomez Villalobos MD, MS

Instructor in Medicine (Pulmonary)

Current Projects

Validation of a genetic signature in the airway of asthmatics exposed to second-hand smoke.

Research Summary

My research focuses on the impact of second-hand smoke in the biology of asthma. Cigarette smoke is a strong environmental influence with a negative effect in lung function and asthma. A better understanding of the interaction between second-hand smoke and asthma has the potential to modify asthma therapies and support the efforts for environmental control and respiratory health.

Extensive Research Description

The alveolar macrophage plays a critical role in response to noxious environmental stimuli and maintenance of gas exchange in the lung. Cigarette smoke disrupts that balance through exposure to inhaled xenobiotic particles, free radical production and immune activation. The alveolar macrophage response to the smoking challenge represents a continuum that ultimately leads to permanent lung function impairment. Secondhand smoke (SHS) is a recognized trigger of asthma exacerbations. However, the behavior of the alveolar macrophage from asthmatics after SHS exposure is only partially known.

Our current project is focused on the characterization of the molecular response to SHS in airway macrophages of asthmatics.

My laboratory is also interested in the integration of high-throughput data generated in our laboratory and publicly accessible data to understand the biology of airways disease and the fundamental molecular processes present across pulmonary disease in general.

Selected Publications

  • Non-invasive Analysis of the Sputum Transcriptome Discriminates Clinical Phenotypes of Asthma. Yan X, Chu JH, Gomez J, Koenigs M, Holm C, He X, Perez MF, Zhao H, Mane S, Martinez FD, Ober C, Nicolae DL, Barnes KC, London SJ, Gilliland F, Weiss ST, Raby BA, Cohn L, Chupp GL. Am J Respir Crit Care Med. 2015 Mar 12.
  • Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40. Gomez JL, Crisafi GM, Holm CT, Meyers DA, Hawkins GA, Bleecker ER, Jarjour N; Severe Asthma Research Program (SARP) Investigators, Cohn L, Chupp GL. J Allergy Clin Immunol. 2015 Jan 12. pii: S0091-6749(14)01725-4.
  • Kellum JA, Hoste E, Gomez JL. Acid-Base State: The Stewart Approach. In: Nefrologia Critica (Critical Care Nephrology). 1st ed. Buenos Aires, Argentina. Ediciones Journal. Chapter 16.
  • Kellum JA, Hoste E, Gomez JL. Definition of Acute Renal Failure. In: Nefrologia Critica (Critical Care Nephrology). 1st ed. Buenos Aires, Argentina. Ediciones Journal. Chapter 1.
  • Gomez JL, Gunnerson KJ, Song M, Li J, Kellum JA. Effects of hypercapnia on blood pressure in hypoalbuminemic and Nagase analbuminemic rats. Chest 2007; 131:1295-1300.

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