John Hwa, MD, PhD

Associate Professor of Medicine (Cardiology); Director of Cardiovascular Pharmacogenetics

Research Interests

Research Organizations

Cardiovascular Medicine

Vascular Biology and Therapeutics Program

Research Summary

We wish to determine why patients with diabetes mellitus have increased vascular thrombosis. We use a combination of approaches including molecular signaling, biochemistry, genomics and proteomics on both human subjects and animal models. The ultimate goal is to develop novel mechanistic based therapies.

Extensive Research Description

The Hwa Laboratory research interests are on eicosanoids and diabetes mellitus, and include a number of large collaborative efforts within Yale and externally. All are focused in the broad areas of eicosanoids, NSAIDs and the development of thrombus on a background of atherosclerosis (atherothrombosis). Our studies extend from fundamental structure function of GPCRs, to pharmacogenetics, molecular signaling, pathophysiology, and clinical outcomes. For our studies we use a number of models including tissue culture cells, platelets, vascular smooth muscle cells, mouse knockout and transgenics, and recruited human patients. Our current studies can be broadly divided into the following major areas.

1) Pharmacogenetics of the prostanoid receptors

2) Platelet dysfunction in diabetes mellitus

3) miRNA regulation of thrombosis

4) The Yale cardiovascular tissue repository collaborative effort

Selected Publications

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Contact Info

John Hwa, MD, PhD
Lab Location
Cardiovascular Research Center300 George Street, Ste 7th Floor
New Haven, CT 06511
Office Location
Cardiovascular Research Center300 George Street, Ste 759H
New Haven, CT 06511
Mailing Address
Section of Cardiovascular MedicinePO Box 208017
New Haven, CT 06520-8017