John Peter Concato MD

Professor of Medicine (General Medicine); Director, Clinical Epidemiology Research Center, VA Connecticut HealthCare System

Research Interests

Screening, prognosis, and treatment strategies; Improving methods of research design and statistical analysis

Research Summary

As a general internist and clinical epidemiologist, I conduct research to address unanswered questions related to screening, prognosis, and treatment strategies, as well as to improve methods of research design and statistical analysis. This dual focus has involved a range of topics in both patient care and methodology; e.g., evaluating the effectiveness of medical interventions, identifying sources of bias in patient-oriented research, and assessing limitations of popular methods of statistical analysis.

Representative projects include evaluating the effectiveness of screening for prostate cancer, with corresponding refinement of observational methods for evaluating screening tests in general. Other projects have compared the results of observational studies and randomized trials, disputing prior claims of a simple "research design hierarchy." Ongoing work involves studies of prognosis in prostate cancer, and clarifying the use of multivariable analysis in patient-oriented research.

Selected Publications

  • Concato J, Jain D, Li WW, Risch HA, Uchio EM, Wells CK. Molecular markers and mortality in prostate cancer. BJU International (In press)
  • Concato J, Wells CK, Horwitz RI, Penson D, Fincke G, Berlowitz DR, Froehlich G, Blake D, Vickers MA, Gehr GA, Raheb NH, Sullivan G, Peduzzi P. The effectiveness of screening for prostate cancer: A nested case-control study. Arch Intern Med. 2006166:38-43.
  • Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med. 2005353:2034-2041
  • Concato J. Challenges in prognostic analysis. Cancer 200191:1607-1614.
  • Concato J, Shah N, Horwitz RI. Randomized, controlled trials, observational studies, and the hierarchy of research designs. N Engl J Med 2000342:1887-1892.

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