Eric RF Meffre PhD

Associate Professor of Immunobiology and of Medicine (Immunology)

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): ImmunologyCancer ImmunologyImmunobiology: HTIInternal Medicine: Allergy & Clinical Immunology

Research Interests

Human B-cell tolerance; Primary immunodeficiencies; Autoimmune diseases more...


  • B.S., University of Paris, 1988
  • M.S., University of Paris, 1989
  • Ph.D., University of Aix-Marseille, France, 1996

Selected Publications

  • A. V. Sauer, H. Morbach, I. Brigida, Y.-S. Ng, A. Aiuti and E. Meffre. Defective B-cell tolerance due to adenosine deaminase deficiency is corrected by gene therapy. 2012. J. Clin. Invest. 122(6):2141-52.
  • E. Meffre. The establishment of early B cell tolerance in humans: lessons from primary immunodeficiency diseases. 2011. Ann. N.Y. Acad. Sci. 1246: 1–10.
  • L. Ménard, D. Saadoun, I. Isnardi, Y.-S. Ng, G. Meyers, C. Massad, C. Price, C. Abraham, R. Motaghedi, J. H. Buckner, P. K. Gregersen and E. Meffre. The PTPN22 risk allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans. 2011. J. Clin. Invest. 121: 3635-44.



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