Edwin Charles Thrower PhD

Senior Research Scientist in Medicine (Digestive Diseases) and Lecturer in Molecular Biophysics and Biochemistry

Research Interests

Pancreatitis

Current Projects

1. Role of Protein Kinase D in acute pancreatitis

2. Tobacco carcinogens intiate and enhance pancreatitis responses

3. pH dynamics in acute pancreatitis

Research Summary

My research focuses on premature activation of digestive zymogens within pancreatic acinar cells, a key event in the initiation of acute pancreatitis (AP). I am currently involved in three projects. The first focuses on protein kinase C (PKC) which has been shown to have multiple roles in the regulation of both physiology and pathophysiology of the pancreas. We have shown that both PKC € isoforms participate in premature zymogen activation in varying degrees and at differing cellular locations. We have further explored downstream targets of PKC including protein kinase D (PKD) and have recently published this work in American Journal of physiology: GI. I am also involved in a project focusing on the role of extracellular and intracellular pH and its function in pancreatitis responses. This study may have clinical implications with regards to the composition of resuscitation buffers used to treat this disease. My final project focuses on the role that the tobacco carcinogen NNK may play in the development of acute pancreatitis and is the first major study exploring a direct link between smoking and acute pancreatitis.


Selected Publications

  • Thrower, Yuan, Usmani, Lui, Jones, Minervini, Alexandre, Pandol, Guha. A novel protein kinase D inhibitor attenuates early events of experimental pancreatitis American Journal of Physiology GI. Thrower, Yuan, Usmani, Lui, Jones, Minervini, Alexandre, Pandol, Guha. 2010 In press
  • Bhoomagoud M, Jung T, Atladottir J, Kolodecik TR, Shugrue C, Chaudhuri A, Thrower EC, Gorelick FS. Reducing extracellular pH sensitizes the acinar cell to secretagogue-induced pancreatitis responses in rats. Gastroenterology. 2009 Sep;137(3):1083-92.
  • Edwin C. Thrower, Alexander P.E. Diaz de Villalvilla, Thomas R. Kolodecik, and Fred S. Gorelick (2006). Zymogen activation in a reconstituted pancreatic acinar cell system. Am J Physiol Gastrointest Liver Physiol 290: G894-G902.
  • Gorelick, F.S., Shugrue, C.A., Kolodecik, T.R. and Thrower, E.C. Vacuolar adenosine triphosphatase and pancreatic acinar cell function. J. Gastroenterol Hepatol. (2006) Oct 21 Suppl 3:S18-21.
  • Waterford, S.D., Kolodecik, T.R., Thrower, E.C. and Gorelick, F.S. (2005) Vacuolar ATPase regulates zymogen activation in pancreatic acini. J. Biol. Chem. 280, 5430-5434.

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