Meena Ananth, PhD

Senior Research Scientist in Medicine (Digestive Diseases)

Research Interests

Digestive System Diseases

Research Organizations

Internal Medicine: Digestive Diseases

Research Summary

Over the last two decades, my research has focused on the mechanisms of regulation of bile acid transporters in liver during development and in pathological situations such as the human liver disease cholestasis. My main focus over the last decade has been on the role of Nuclear Receptors (with specific reference to FXR) on the regulation of Bile salt export pump (BSEP) a canalicular transporter for bile acids in the hepatocytes. I have recently also explored the role of microRNAs (mIRs) in regulating bile salt transporters in liver in physiology and pathophysiology. Since the beginning of this year, I am conducting research into molecular mechanisms of regulation of Inositol 3-phosphate receptors (IP3Rs) that act as Ca-channels in the endoplasmic reticulum (ER) with specific focus on the promoters of the Type 2 and 3 isoforms and their regulation by microRNAs.

Extensive Research Description


1. Regulatory mechanisms of Type 2 and Type 3 Inositol 3-phosphate receptors (IP3Rs) in hepatocytes and cholangiocytes respectively by isolation and characterization of their respective promoters

2. Role of microRNAs (mIRs) in regulation of Type 2 and Type 3 Inositol 3-phosphate receptors (IP3Rs)

3. Molecular Mechanisms of Bile acid/organic ion transporter regulation in hepatic physiological and pathological states including cholestasis

Selected Publications

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Contact Info

Meena Ananth, PhD
Lab Location
Section of Digestive DiseasesThe Anlyan Center
300 Cedar Street, Ste S230

New Haven, CT 06519
Office Location
Section of Digestive DiseasesThe Anlyan Center
300 Cedar Street, Ste S230

New Haven, CT 06519