Departments & Organizations
1980 Ph.D Biochemistry Postgraduate Inst of Medical Education and
Research, Chandigarh, India
1981 - 83 Postdoc Research Inst of Scripps Clinic, La Jolla, CA
1983 - 87 Res. Assoc Dept of Biochemistry, USC School of Medicine
Los Angeles, CA
1987 - 88 Asst Prof Div. GI, Dept of Pediatrics, Children's Hosp
Univ. of Cincinnati, Cincinnati, OH
1988 - 96 Assoc. Res. Sci Div GI, Dept of Pediatrics, Yale Univ. Sch Med.
New Haven, CT
1996 -2010 Assoc. Prof. Dept of Pediatrics, Mount Sinai Sch. Med.
New York, NY
2011 - to date Sen. Res Sci Div. of GI, Dept of Medicine, Yale Univ. Sch. Med
New Haven, CT
Over the last decades, my research has focused on the mechanisms of regulation of bile acid transporters in liver during development and in pathological situations such as the human liver disease cholestasis. My main focus over the last decade has been on the role of Nuclear Receptors (with specific reference to FXR) on the regulation of Bile salt export pump (BSEP) a canalicular transporter for bile acids in the hepatocytes. I have recently also explored the role of microRNAs (mIRs) in regulating bile salt transporters in liver in physiology and pathophysiology. Since the beginning of this year, I am conducting research into molecular mechanisms of regulation of Inositol 3-phosphate receptors (IP3Rs) that act as Ca-channels in the endoplasmic reticulum (ER) with specific focus on the promoters of the Type 2 and 3 isoforms and their regulation by microRNAs.
Education & Training
|PhD||Postgraduate Inst Medical Education and Research, Chandigarh, India, Biochemistry (1980)|
|PhD||University of Madras, India (1980)|
|Research Associate||USC School of Medicine|
|Postdoctoral Fellow||Research Institute of Scripps Clinic , La Jolla, CA|