Albert C Shaw MD, PhD
Associate Professor of Medicine (Infectious Diseases)
Mechanisms underlying the functional decline of the immune system with aging
Research in the Shaw laboratory is directed toward understanding the mechanisms underlying the functional decline of the immune system with aging. Ongoing projects include studies on the function of presenilins—proteins implicated in the pathogenesis of Alzheimer's Disease—in cells of the immune system. In addition, the laboratory is examining the role of mammalian topoisomerases in the control of DNA repair, genomic stability and age-related alterations in the immune system. Finally, we are engaged in ongoing studies in humans that seek to elucidate age-related changes in the innate immune system (such as the Toll-like receptors), and to correlate such changes with responsiveness to vaccines (which decreases substantially in older adults) and susceptibility to infectious diseases.
- Shaw, A.C., Goldstein, D.R., Montgomery, R.R. (2013). Age-dependent dysregulation of innate immunity. Nat. Rev. Immunol. 13: 875-887.
- Panda A., Chen S., Shaw, A.C., Allore, H.G. (2013). Statistical approaches for analyzing immunologic data of repeated observations: a practical guide. J. Immunol. Methods 398-399:19-26
- Kang, K.S., Lee N., Shin, M.S., Kim, S.D., Montgomery, R.R., Shaw, A.C., Kang, I. (2013). An altered relationship of influenza vaccine-specific IgG immune responses with T cell immunity occurs with aging in humans. Clin. Immunol. 147:79-88.
- Xu, D., Shen W., Guo, R., Xue, Y., Peng, W., Sima, J., Yang J., Sharov A., Srikantan, S., Yang, J., Fox, 3rd, D., Qian Y., Martindale, J., Piao, Y., Machamer, J., Joshi, S.R., Mohanty, S., Shaw, A.C., Lloyd, T.E., Brown, G.W., Ko, M.S.H., Gorospe, M., Zou, S., Wang, W. (2013). Top3ß is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation. Nat. Neurosci. 16:1238-1247.
- Reis, E.A., Hagan, J.E, Ribeiro, G.S., Teixeira-Carvalho, A., Martins-Filho, O.A., Montgomery, R.R., Shaw, A.C., Ko, A.I., Reis, M.G. (2013). Cytokine response signatures in disease progression and development of severe clinical outcomes in leptospirosis. PLoS Negl Trop Dis. 7:e2457.
- Qian F., Wang X., Zhang L., Chen S., Piecychna M, Allore H., Bockenstedt L.K., Malawista S.E., Bucala R., Shaw A.C., Fikrig E., Montgomery R.R. (2012). Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly. Aging Cell 11:104-110.
- Panda, B., Panda, A., Ueda, I., Abrahams, V.M., Norwitz, E.R., Stanic, A.K., Young, B.C., Ecker, J.L., Altfeld, M., Shaw, A.C., Rueda, B.R. (2012). Dendritic cells in the circulation of women with preeclampsia demonstrate a pro-inflammatory bias secondary to dysregulation of TLR receptors. J. Reprod. Immunol. 94: 210-215.
- Shaw, A.C., Panda, A., Joshi, S.R., Qian, F., Allore, H.G., Montgomery, R.R. (2011). Dysregulation of human Toll-like receptor function in aging. Ageing Res. Rev. 10: 346-353.
- Panda, A., Qian, F., Mohanty, S., van Duin, D., Newman, F.K., Zhang, L., Chen, S., Towle, V.,
Belshe, R.B., Fikrig, E., Allore, H.G., Montgomery, R.R., Shaw, A.C. (2010). Age-associated decrease in Toll-like receptor function in primary human dendritic cells predicts influenza vaccine response. J. Immunol. 184: 2518-2527.
- Panda, A., Arjona, A., Sapey, E., Bai, F., Fikrig, E., Montgomery, R.R., Lord, J.M., Shaw, A.C. (2009). Human innate immunosenescence: causes and consequences for immunity in old age. Trends Immunol. 30: 325-333.