Sarwat I Chaudhry MD

Associate Professor of Medicine (General Medicine); Principal Investigator (SILVER-AMI Study)

Research Interests

Heart failure; Geriatric Conditions; Functional Disability; Quality of Life; Remote Monitoring; End of Life Issues

Research Summary

Dr. Chaudhry’s research is directed toward improving outcomes in older patients with heart failure. She is currently funded by the NIH to conduct studies to determine the prognostic importance of geriatric conditions in patients with heart failure. She also has an interest in remote monitoring systems in heart failure.

Extensive Research Description

In addition to her role as Director of the Academic Hospitalist Program at the Yale University School of Medicine and Yale New Haven Hospital, Dr. Sarwat Chaudhry is an accomplished outcomes researcher who has earned National and University honors, and authored numerous peer-reviewed publications. She is Principle Investigator for NIH-funded, large-scale studies focused on improving outcomes in hospitalized patients, and is one of the few investigators in the country to focus her research on older patients hospitalized for cardiovascular disease.

In 2012, she was awarded R01 funding from NIH / NHLBI to develop and validate risk stratification models for older patients hospitalized with acute myocardial infarction (“SILVER-AMI”). This study is currently underway, and integrates principles from both geriatrics and cardiology to develop post-AMI risk models specifically designed for patients 75 years of age and older. Her team established a recruitment network of nearly 100 cardiology practices across the country, consisting primarily of community based groups, who will enroll 3000 participants.

Her PRosPECt-HF trial (“PRimary PalliativE Care for Heart Failure), recently funded by the National Palliative Care Research Center, seeks to integrate palliative care into heart failure management. This study was inspired by her previous research where she served as Director of Science in the largest clinical trial to date of remote symptom monitoring for patients with heart failure. “Telemonitoring in Patients with Heart Failure,” tracked symptoms and weight of patients recently discharged after hospitalization for heart failure to determine the value of daily symptom monitoring to avert readmissions. Results delivered a clear verdict that telemonitoring during this transition-of-care period did not, in fact, improve readmission or mortality. This work also initiated a much-needed investigation into the high burden of symptoms suffered by heart failure patients following hospitalization.

Dr. Chaudhry’s expertise in clinical study design and patient interventions, and her experience with establishing nation-wide recruitment networks, makes her an excellent teacher. She has mentored numerous junior faculty members, Internal Medicine residents, as well as students from the School of Medicine and Nursing interested in exploring clinical research.

Selected Publications

  • Sacco-Gibson N. Chaudhry S. Brock A. Sickles AB. Patel B. Hegstad R. et al. Cadmium Effects on Bone Metabolism: Accelerated Resorption in Ovariectomized, Aged Beagles. Toxicology & Applied Pharmacology. 1992; 113:274-83.
  • Chaudhry SI, Olofinboba KA, Krumholz HM. Detection of Errors by Attending Physicians on a General Medicine Service. Journal of General Internal Medicine. 2003; 18:595-600.
  • Chaudhry SI, Foody JM, Krumholz HM. Management of Systolic Hypertension in Older Adults. JAMA. 2004; 292; 1074-1080.
  • Chaudhry SI, Friedkin RF, Horwitz RI, Inouye SK. Educational Disadvantage Impairs Functional Recovery After Hospitalization in Older Persons. American Journal of Medicine. 2004; 117; 650-656.
  • Chaudhry SI, Berlowitz DR, Concato J. Do Age and Comorbidity Affect Intensity of Therapy for Poorly Controlled Diabetes Mellitus? Journal of the American Geriatrics Society. 2005; 53(7):1214-6.
  • Foody JM, Chaudhry SI, Krumholz HM. Systolic Hypertension in Older Persons: Complexities in Clinical Decision Making. American Journal of Geriatric Cardiology. 2005; 14(6):325-30.
  • Chaudhry SI, Phillips CO, Riegel B, Jerant AF, Stewart S, Krumholz HM. Telemonitoring in Patients with Heart Failure: A Systematic Review. Journal of Cardiac Failure. 2007; 13 (1):56-62.
  • Chaudhry SI, Wang Y, Concato J, Gill TM, Krumholz HM. Patterns of Weight Change Preceding Hospitalization for Heart Failure. Circulation; 2007; 116 (4): 1549-1554.
  • Chaudhry SI, Barton B, Mattera J, Spertus J, Krumholz, HM. Randomized Trial of Telemonitoring to Improved Heart Failure Outcomes (Tele-HF): Study Design. Journal of Cardiac Failure. 2007; 13(9):709-714.
  • Chaudhry SI, Wang Y, Gill TM, Krumholz HM. Geriatric Conditions and Subsequent Mortality in Older Persons with Heart Failure. Journal of the American College of Cardiology. In Press.

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