Raymond Richard Russell MD, PhD

Associate Professor of Medicine (Cardiology) and of Diagnostic Radiology; Co-Director, Cardiovascular Training and Education Cardiovascular Medicine

Research Interests

Regulation of cardiac metabolism in the setting of ischemia; Heart failure and diabetes


Research Summary

Regulation of cardiac metabolism in the setting of myocardial ischemia, heart failure and diabetes. This research focuses on the regulation of carbohydrate and fatty acid metabolism in the heart by AMP-activated protein kinase as well as the role of uncoupling proteins (UCP2 and UCP3) in metabolic regulation and cardioprotection. These interests include studies in animal models and clinical PET imaging in patients.


Selected Publications

  • Guzman CF, Bugger H, Zechner C, Palmeri M, Russell RR. Uncoupling proteins 2 and 3 are downregulated in the failing heart: Implications for energy metabolism and oxidant stress injury. In preparation.
  • Laskowski KR, Russell RR. Uncoupling proteins in heart failure. Curr Heart Failure Rep. In press.
  • Russell RR, Abbott, BG, Arrighi JA, Bengel FM, Cohen MC, Garcia EV, Hendel RC, Holly TA, Mieres JH, Shaw LJ, et al. Highlights of the 2007 Scientific Sessions of the American Society of Nuclear Cardiology: San Diego, California, September 6 9, 2007. J Am Coll Cardiol 50:2336-2343, 2007.
  • Russell RR. Stress signaling in the heart by AMP-activated protein kinase. Curr Hyperten Rep 8:446-450, 2006.
  • Russell RR, Zaret BL. Nuclear Cardiology: Present and Future. Curr Prob Cardiol 31: 551-630, 2006.

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