Mark Joseph Mamula, PhD

Professor of Medicine (Rheumatology)

Research Interests

Autoantigens; Autoimmune Diseases; Immune System; Rheumatology; T-Lymphocytes; Autoimmunity

Research Organizations

Internal Medicine: Rheumatology: Rheumatic Diseases Research Core

Faculty Research

Immunology and Immunotherapy

Skin Diseases Research Center, Yale

Yale Cancer Center: Cancer Immunology

Office of Cooperative Research

Research Summary

The immune system maintains a delicate balance in its ability to recognize and eliminate foreign pathogens versus its ability to be tolerant of self tissues. Dr. Mamula has had a long standing interest in investigating the early events involved with the induction of autoimmunity. It is the goal of Dr. Mamula's laboratory to understand the mechanisms that may shift this balance toward the initiation of autoimmune responses. In particular, his efforts have centered on the molecular interactions of autoimmune B and T lymphocyte responses to intracellular autoantigens in systemic lupus erythematosus (SLE). His laboratory is also interested in determining the forms of autoantigens capable of breaking immunologic tolerance, the processing of these autoantigens, and understanding the role of autoreactive T cells in autoimmune diseases such as lupus and diabetes. More recently, Dr. Mamula has also been applying some his studies towards developing “autoimmune” responses against tumor tissues, in particular, models of melanoma and breast cancer. These latter studies have evolved into novel approaches for the design of therapeutic tumor vaccines.

Specialized Terms: Autoimmune diseases

Extensive Research Description

Dr. Mamula is studying how, in lupus, the body targets itself for attack by its own immune system. Identifying the mechanisms that initiate this process can then help in devising an intervention that will stop this self-destructive cascade.

Selected Publications

Full List of PubMed Publications

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Contact Info

Mark Joseph Mamula, PhD
Mailing Address
PO Box 208031
333 Cedar Street

New Haven, CT 06520-8031