Margaret Ann Pisani MD, MPH

Associate Professor of Medicine (Pulmonary); Program Director, Pulmonary and Critical Care Medicine Fellowship; Co-Director Sleep in the ICU Task Force

Research Interests

Sleep in critical illness

Current Projects

Sleep in the ICU
Treatment of ICU Delirium
Biomarkers for delirium
Outcomes of older ICU patients after critical illness
Outcomes of patients after rapid response team assessments
Outcomes after thoracic interventional procedures

Research Summary

Dr. Pisani performs clinical research in the field of pulmonary, critical care and sleep medicine. She has focused much of her research on outcomes in older intensive care unit patients. Specifically, she has looked at the prevalence of pre-existing cognitive impairment of patients admitted to the MICU and physician recognition of the impairment. She has also examined risk factors for poor outcomes from ICU care in older patients.

Her work has focused on predisposing risk factors as well as precipitating or modifiable risk factors such as medication use in the intensive care unit. She is interested in delirium, its pathogenesis, treatment and impact on outcomes.

She is currently studying sleep in an intensive care unit population. She is examining risk factors for sleep disruption, use of portable polysomnography in the ICU, and the impact of sleep deprivation on delirium and other ICU outcomes.

She is also examining the impact of rapid response team calls on older patients.

She also is a co-investigator in the Interventional Pulmonary (IP) research program where she provides expertise in clinical study design and data analysis. Projects from IP have included studies of the etiology of bilateral pleural effusions, safety of performing thoracentesis in patients with bleeding risks, impact of thoracentesis on dyspnea and quality of life, safety and tolerability of endobronchial ultrasound EBUS under conscious sedation and in obese patients.

Her studies have been funded by the Yale Pepper Center on Aging, American Lung Association, The Chest Foundation, The Hartford Foundation and Merck/American Federation on Aging Research and the NIH.

Selected Publications

  • Puchalski JT, Argento AC, Murphy TE, Araujo KLB, Olivia I, Rubinowtiz A, Pisani MA. Etiologies of bilateral pleural effusions. Respir Med. 2013 Feb;107(2):284-91. PMID: 23219348
  • Puchalski JT, Argento AC, Murphy TE, Araujo KLB, Pisani MA. The safety of thoracentesis in patients with uncorrected bleeding risk. Ann Am Thorac Soc. 2013 Aug;10(4):336-41. PMID: 23952852
  • Pisani MA, Bramley K, Vest MT, Araujo KLB, Murphy TE. Patterns of benzodiazepine, opiate and antipsychotic drug administration in a medical intensive care unit. Am J Crit Care. 2013 Sep;22(5):e62-e69. PMID:23996429
  • Murphy TE, Van Ness PH, Araujo, KLB, Pisani MA. Bayesian Time Series Analysis of a Repeated Measures Poisson Outcome with Excess Zeroes. Am J Epidemiology, 2011 Dec 1; 174(11):1230-7.
  • Vest MT, Murphy TE, Araujo KL, Pisani MA. Disability in activities of daily living, depression, and quality of life among older medical ICU survivors: a prospective cohort study. Health Qual Life Outcomes 2011; Feb 5; 9:9.
  • Pisani MA, Murphy TE, Araujo KA, Van Ness PH. Factors associated with persistent delirium after intensive care unit admission in an older medical patient population. J Crit Care 2010 April 21 PMID:20413252
  • Pisani MA, Kong SY, Kasl SV, Murphy TE, Araujo KL, Van Ness PH. Days of Delirium are Associated with 1-year Mortality in an Older Intensive Care Unit Population. Am J Respir Crit Care Med. 2009 Sep 10. [Epub ahead of print]
  • Pisani MA, Murphy TE, Araujo KA, Slattum P, Van Ness PH, Inouye SK. Benzodiazepine and opioid use and the duration of ICU delirium in an older population. Critical Care Medicine, 2009 37(1):177-183.
  • Pisani MA, Murphy TE, Van Ness PH, Araujo KLB, Inouye SK. Admission characteristics associated with delirium in older patients in a medical intensive care unit. Arch Intern Med 2007 167 (15):1629-1634.
  • Pisani MA, Araujo KLB, Van Ness PH, Zhang Y, Ely EW, Inouye SK. A research algorithm to improve detection of delirium in the intensive care unit. Crit Care. 2006 Aug 1810(4):R121.


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