Li Wen MD, PhD

Senior Research Scientist in Medicine (Endocrinology); Director of Core Laboratory of Yale Center for Clinical Investigation (YCCI)

Research Summary

Our research interest lies mainly in autoimmunity, in particular the immunology of type 1 diabetes. Using different animal models, my research group has been trying to understand why immune cells attack insulin producing islet beta cells and how we can prevent this attack and if we can reverse the autoimmune destruction after the disease onset. Our current research topics include a) the role of innate immunity in type 1 diabetes; b) gut flora in health and disease; c) the study of regulatory T cells; d) “humanized” diabetes model; e) anti-CD20 therapy; f) the role of Toll like receptors in diabetes complications and g) Islet transplantation.

Selected Publications

  • L Wen, RE Ley, PY Volchkov, PB Stranges, L Avanesyan, AC Stonebraker, CY Hu, SF Wong, GL Szot, JA Bluestone, JI Gordon and AV Chervonsky. Innate immunity and intestinal microbiota in the development of type 1 diabetes. Nature, 2008, 455:1109-13.
  • CY Hu, D Rodriguez-Pinto, W Du, A Ahuja, O Henegariu, FS Wong, MJ Shlomchik and L Wen. Autoimmune diabetes prevention and reversal by anti-CD20 therapy. J Clin. Invest. 2007, 117:3857-3867.
  • W Du, F. S Wong, M O. Li, J Peng, H Qi RA. Flavell, R Sherwin and L Wen. TGF-b signaling is required for the function of Insulin Reactive T Regulatory Cells. J. Clin. Invest, 2006 116:1360-1370.
  • FS Wong and L Wen. B cells in Autoimmune Diabetes. Review of Diabetes Studies 2:121-135, 2005.
  • F.S. Wong, W Du, I Thomas and L Wen. The influence of major histocompatibility complex on development of autoimmune diabetes in RIP-B7.1 mice. Diabetes 2005, 54:2032-2040.

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