Joseph Edgar Craft, MD

Paul B. Beeson Professor of Medicine (Rheumatology) and Professor of Immunobiology; Section Chief, Rheumatology; Program Director, Investigative Medicine; Paul B. Beeson Professor of Medicine

Research Interests

Lupus Erythematosus, Systemic

Research Organizations

Cancer Immunology

Immunobiology: HTI

Immunology and Immunotherapy

Internal Medicine: Rheumatology

Research Summary

We have a longstanding interest in dissecting the pathogenesis of systemic autoimmunity, focusing upon the activation and differentiation of CD4 T effector cell subsets in mice and in humans. Our lab has characterized CD4 T cells that help B cells in murine models of lupus and in conventional immune responses, with the idea that information gleaned from the latter studies could be applied to our understanding of autoimmunity. In recent work, we have begun to define the transcription factors critical for the development and function of CD4 T cells that help B cells, with ongoing studies aimed at further investigating these cells developmentally, and dissecting the mechanisms that lead to their effector function in autoimmunity and inflammation.

Extensive Research Description

Ongoing studies are targeted towards identification of the developmental pathways of CD4 T cells that provide B cell help and that promote inflammation, and dissection of their potential to promote autoimmunity and inflammation.

Selected Publications

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Contact Info

Joseph Edgar Craft, MD
Patient Care Locations
Lippard Lab for Clinical Investigation
15 York Street

New Haven, CT 06510
Yale-New Haven Hospital
20 York Street

New Haven, CT 06510
Mailing Address
PO Box 208031
300 Cedar Street

New Haven, CT 06520-8031