Jonathan Meiss Siner MD

Assistant Professor of Medicine (Pulmonary); Medical Director - Medical Intensive Care Unit, Yale-New Haven Hospital

Research Interests

Vascular Growth Factors; Sepsis pathophysiology; Host Response to Viral Infections

Research Summary

Dr. Siner currently conducts translational research examining the role of circulating growth factors in the sepsis syndrome and their relationship to outcomes in the intensive care unit. Patients with a diagnosis of sepsis are enrolled from the Medical Care Intensive Care Unit at Yale-New Haven Hospital. Plasma and DNA specimens are obtained and extensive clinical data is abstracted and entered into a clinical database. These investigations drawn on the extensive basic science activity conducted in the Pulmonary Section and examine these discoveries in humans with sepsis and ARDS (supported by an award from the CTSA). He was the recipient of an NIH National Research Service Award (NRSA) which supported his investigation of the role of VEGF and HO-1 in cytoprotection from hyperoxia induced acute lung inury. He is a site co-investigator on several ongoing multi-center trials investigating novel treatments for Sepsis, ARDS and Interstitial Lung Disease.

Selected Publications

  • Mathai SK, Gulati M, Peng X, Russell TR, Shaw AC, Rubinowitz AN, Murray LA, Siner JM, Antin-Ozerkis DE, Montgomery RR, Reilkoff RA, Bucala RJ, Herzog EL. Circulating monocytes from systemic sclerosis patients with interstitial lung disease show an enhanced profibrotic phenotype. Lab Invest. 2010 Jun;90(6):812-23.
  • Siner JM, Bhandari V, Engle KM, Elias JA, Siegel MD. Elevated serum angiopoietin 2 levels are associated with increased mortality in sepsis. Shock. 2009 Apr;31(4):348-53.
  • Siner JM, Pisani MA. Mechanical ventilation and acute respiratory distress syndrome in older patients. Clin Chest Med. 2007 Dec;28(4):783-91
  • Siner JM, Manthous CA. Liberation from mechanical ventilation: what monitoring matters? Crit Care Clin. 2007 Jul;23(3):613-38
  • Siner JM, Jiang G, Cohen ZI, Shan P, Zhang X, Lee CG, Elias JA, Lee PJ. VEGF-induced Heme Oxygenase-1 confers cytoprotection in lethal hyperoxic acute lung injury in vivo. FASEB Journal 2007 May;21(7):1422-32. Epub 2007 Jan 30.
  • Siner J, Paredes A, Hosselet C, Hammond T, Strange K, Harris HW. Cloning of an aquaporin homologue present in water channel containing endosomes of toad urinary bladder. Am J Physiol. 1996 Jan;270(1 Pt 1):C372-81.

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