John Concato MD, MS, MPH

Professor of Medicine (General Medicine); Director, Clinical Epidemiology Research Center, VA Connecticut HealthCare System

Research Interests

Screening, prognosis, and treatment strategies; improving methods of research design and statistical analysis


Research Summary

As a general internist and clinical epidemiologist, Dr. Concato conducts research to address questions related to screening, prognosis, and treatment strategies, as well as to improve methods of study design and statistical analysis. This dual focus has involved a range of topics in both patient care and research methodology. Examples include evaluating the effectiveness of screening for prostate cancer, studies of prognosis in prostate cancer, comparing the results of observational studies and randomized trials, and clarifying the use of multivariable analysis in patient-oriented research. More recent (“center-based”) research includes projects in genomic medicine, as part of the VA Cooperative Studies Program and Genomic Medicine Program.


Selected Publications

  • Concato J. Study design and “evidence” in patient-oriented research. Am J Respir Crit Care Med. 2013;187:1167-1172.
  • Concato J. Probabilities, uncertainty, and prostate cancer. Ann Intern Med. 2013;158:211-212.
  • Concato J. Is it time for medicine-based evidence? JAMA 2012;307:1641-1643.
  • Concato J, Lawler EV, Lew RA, Gaziano JM, Aslan M, Huang GD. Observational methods in comparative effectiveness research. Am J Med 2010;123,Supp1:e16-e23.
  • Concato J, Wells CK, Horwitz RI, Penson D, Fincke G, Berlowitz DR, Froehlich G, Blake D, Vickers MA, Gehr GA, Raheb NH, Sullivan G, Peduzzi P. The effectiveness of screening for prostate cancer: A nested case-control study. Arch Intern Med. 2006;166:38-43.
  • Concato J, Shah N, Horwitz RI. Randomized, controlled trials, observational studies, and the hierarchy of research designs. N Engl J Med 2000;342:1887-1892.

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