Carolyn M. Macica, PhD
Associate Research Scientist in Medicine (Endocrinology)
Research Interests
Enthesopathy in X-Linked Hypophosphatemia
Research Summary
Dr. Carolyn Macica’s project, “A Study of Enthesopathy in X-Linked Hypophosphatemia,” is focused on a particularly debilitating complication of XLH in later years. She will study the progression and pathogenisis underlying the paradoxical calcification of tendon and ligament insertion sites. Dr. Macica states: “The formation of enthesophytes will be our focus, with a major emphasis on characterizing the cellular changes that occur in enthesophyte formation using the murine model of XLH, Hyp mice. We have found that mineralization, while thought to originate from the bone, is actually due to both an expansion of fibrocartilage cells that express the FGFR3 receptor and an increase in alkaline phosphatase activity. Our goal is to study the role of elevated circulating levels of FGF23 in fibrocartilage expansion using FGFR3 knockout mice on the Hyp background and in Dmp1 knockout mice, another model of osteomalacia characterized by elevated FGF23 levels, independent of the Phex mutation. We have evidence that an increase in chondrocyte-derived alkaline phosphatase is likely involved in the mineralization of both entheses and in articular cartilage. We also aim to better characterize the dysregulation of alkaline phosphatase specific to cells of chondrocyte (vs. osteoblast) origin.”
Selected Publications
- G Liang, LD Katz, KL Insogna, TO Carpenter, CM Macica*. A Study of the Enthesopathy of X-linked Hypophosphatemia. Calcified Tissue International, Volume 85 (3) 235-242, 2009.
- X Chen, CM Macica, A Nasiri, AE Broadus. Regulation of articular chondrocyte proliferation and differentiation by indian hedgehog and parathyroid hormone-related protein in mice Arthritis & Rheumatism 58 (12): 3788-3797, 2008.
- X Chen, CM Macica, A Nasiri, S Judex, AE Broadus. Mechanical regulation of PTHrP expression in entheses. Bone. Nov;41(5):752-9, 2007.
- AE Broadus CM Macica, and X Chen. The PTHrP functional domain is at the gates of endochondral bones. Ann N Y Acad Sci. Nov;1116:65-81, 2007.
- G Liang, GW Cline, and CM Macica*. IGF-I stimulates de novo fatty acid biosynthesis by Schwann cells during myelination. Glia, 55(6):632-48, 2007.
- CM Macica*, G. Liang, KL Lankford, AE Broadus. Induction of parathyroid hormone-related peptide following peripheral nerve injury: role as a modulator of Schwann cell phenotype. Glia. 15;53(6):637-48, 2006.
- Chen X, CM Macica, DE Dreyer, VE Hammond, JR Hens, WM Philbrick, AE Broadus. Initial characterization of PTH-related protein gene-driven lacZ expression in the mouse. J Bone Miner Res 21(1):113-23, 2006.
- Chen X, CM Macica, KW Ng, AE Broadus. Stretch-induced PTH-related protein gene expression in osteoblasts. J Bone Miner Res 20(8):1454-61, 2005.
- CM Macica, AE Broadus. PTHrP regulates cerebral blood flow and is neuroprotective, editorial focus. Amer J Regul Comp Physiol (4):R1019-20, 2003.
- CM Macica, CAA von Hehn, LY Wang, CS Ho, S Yokoyama, RH Joho, LK Kaczmarek. Modulation of the Kv3.1b isoform adjusts the fidelity of the firing pattern of auditory neurons. J Neurosci 23(4):1133-41, 2003.
Selected Publications
- G Liang, LD Katz, KL Insogna, TO Carpenter, CM Macica*. A Study of the Enthesopathy of X-linked Hypophosphatemia. Calcified Tissue International, Volume 85 (3) 235-242, 2009.
- X Chen, CM Macica, A Nasiri, AE Broadus. Regulation of articular chondrocyte proliferation and differentiation by indian hedgehog and parathyroid hormone-related protein in mice Arthritis & Rheumatism 58 (12): 3788-3797, 2008.
- X Chen, CM Macica, A Nasiri, S Judex, AE Broadus. Mechanical regulation of PTHrP expression in entheses. Bone. Nov;41(5):752-9, 2007.
- AE Broadus CM Macica, and X Chen. The PTHrP functional domain is at the gates of endochondral bones. Ann N Y Acad Sci. Nov;1116:65-81, 2007.
- G Liang, GW Cline, and CM Macica*. IGF-I stimulates de novo fatty acid biosynthesis by Schwann cells during myelination. Glia, 55(6):632-48, 2007.
- CM Macica*, G. Liang, KL Lankford, AE Broadus. Induction of parathyroid hormone-related peptide following peripheral nerve injury: role as a modulator of Schwann cell phenotype. Glia. 15;53(6):637-48, 2006.
- Chen X, CM Macica, DE Dreyer, VE Hammond, JR Hens, WM Philbrick, AE Broadus. Initial characterization of PTH-related protein gene-driven lacZ expression in the mouse. J Bone Miner Res 21(1):113-23, 2006.
- Chen X, CM Macica, KW Ng, AE Broadus. Stretch-induced PTH-related protein gene expression in osteoblasts. J Bone Miner Res 20(8):1454-61, 2005.
- CM Macica, AE Broadus. PTHrP regulates cerebral blood flow and is neuroprotective, editorial focus. Amer J Regul Comp Physiol (4):R1019-20, 2003.
- CM Macica, CAA von Hehn, LY Wang, CS Ho, S Yokoyama, RH Joho, LK Kaczmarek. Modulation of the Kv3.1b isoform adjusts the fidelity of the firing pattern of auditory neurons. J Neurosci 23(4):1133-41, 2003.
- CM Macica, LK Kaczmarek. Casein kinase 2 determines the voltage dependence of the Kv3.1 channel in auditory beurons and transfected cells. J Neurosci 21:116-68, 2001.
- CM Macica, YH Yang, K Lerea, SC Hebert, WH Wang. Role of the NH2 terminus of the cloned renal K channel, ROMK1, in arachidonic acid-mediated inhibition channel, ROMK1. Am J Physiol 43:F175-81, 1998.
- CM Macica, Y Yang, SC Hebert, WH Wang. Arachidonic acid inhibits the activity of the cloned renal K channel, ROMK1. Am J Physiol 271:F588-94, 1996.
