Carol J Soroka, PhD

Senior Research Scientist in Medicine (Digestive Diseases); Technical Director, Liver Center Morphology Core

Departments & Organizations

Internal Medicine: Digestive Diseases | Liver Center

Faculty Research


I received my Ph.D. in Microbiology in 1986 from State University of New York at Buffalo. After post-doctoral work at Yale in the Departments of Cell Biology and Surgery, I joined the laboratory of Dr. James L. Boyer in Internal Medicine/Digestive Diseases in 1993. The emphasis of this lab is the study of mechanisms in bile formation and cholestasis. I have primarily studied animal models of liver injury, with an emphasis on membrane transporters. For the last ten years I have focused on characterization of the Organic Solute Transporter alpha-beta, a heteromeric transporter primarily responsible for the enterohepatic circulation of bile acids. In the past year I have begun a study of progenitor (stem) cells in human liver, using liver organoids to look at genetic changes in cholangiocytes from patients with cholestasis, especially Primary Sclerosing Cholangitis.

Education & Training

PhD SUNY at Buffalo (1986)

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Contact Info

Carol J Soroka, PhD
Mailing Address
Int Med-Digestive
Yale University

New Haven, CT 06520-8019

Curriculum Vitae

Yale Liver Center

Liver organoids from three patients

Ductular derived progenitor cells were isolated from explants of human livers and grown in culture under defined conditions. These organoids express cholangiocyte and stem cell markers They have been maintained in culture for >1 month and frozen down for future genetic analysis.