Anil K Karihaloo PhD
Assistant Professor of Medicine (Nephrology)
Epithelial morphogenesis and the associated cell signaling; Renal fibrosis; Polycystic Kidney Disease
1. Understanding role of chemokine receptor, Cxcr4 in kidney development
2. Role of Cxcr4 in renal fibrosis
3. Determine whether a sub-population of Cxcr4 positive circulating myeloid cells can be used as biomarker for progressive chronic kidney disease
Our laboratory is currently interested in understanding how G-protein coupled chemokine receptor Cxcr4 modulates kidney development and fibrosis
Extensive Research Description
My laboratory is currently interested in determining what role chemokine receptor Cxcr4 plays in a developing and in an adult kidney. Cxcr4 is a seven-transmembrane G-protein coupled receptor protein known for its co-receptor activity for HIV-I and stem-cell homing. Its role in a developing kidney is only now being studied, partly because the Cxcr4 null mice die in-utero.Our laboratory has recently determined that it is also expressed in epithelial compartments of a developing and adult kidney. We observed that Cxcr4 positively contributes to ureteric-bud branching and may be involved in mesenchymal-to-epithelial transition (MET).
We also determining its potential involvement in the progression of renal fibrosis.
- Anti-fibrosis therapy and diabetic nephropathy.
Curr Diab Rep. 2012 Aug;12(4):414-22.
- Macrophages promote cyst growth in polycystic kidney disease.
Karihaloo A, Koraishy F, Huen SC, Lee Y, Merrick D, Caplan MJ, Somlo S, Cantley LG. J Am Soc Nephrol. 2011 Oct;22(10):1809-14. Epub 2011 Sep 15.
PMID: 21921140 [PubMed - in process]
- Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis.
Takiar V, Nishio S, Seo-Mayer P, King JD Jr, Li H, Zhang L, Karihaloo A, Hallows KR, Somlo S, Caplan MJ. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2462-7. Epub 2011 Jan 24.
- Joseph Ueland, Amy Yuan, Arnaud Marlier, Anna-Rachel Gallagher and Anil Karihaloo. A novel role for the chemokine receptor Cxcr4 in kidney morphogenesis, an in-vitro study. Dev Dynamics. 2009; 238 (5): 1083-91
- Marlier A, Schmitt-Ott K, Gallagher AR, Barasch J, Karihaloo A. Vegf as an epithelial cell morphogen modulates branching morphogenesis of embryonic kidney by directly acting on the ureteric-bud. Mech Dev. 126 (2009) 91-98
- Anil Karihaloo, Feng Wei, Zhiheng Yu, Arnaud Marlier, Pankaj Seth, Sekiya Shibazaki, Tong Wong, Vikas Sukhatme, Stefan Somlo, and Lloyd G Cantley. Neutrophil gelatinase-associated lipocalin suppresses cyst growth by Pkd1 null cells in vitro and in vivo. Kidney International 2008 74(10): 1310-8
- Americo E. Esquibies, Alia Bazzy-Asaad, Farshid Ghassemi, Hitoshi Nishio, Anil Karihaloo, and Lloyd G. Cantley. VEGF attenuates hyperoxic injury through decreased apoptosis in explanted rat embryonic lung. Pediatric research. 2008, 63 (1), 20-5.
- Karihaloo A Grimm DH**, Cai Y, Somlo S, Cantley LG, and Caplan MJ. Polycystin-2 regulates proliferation and branching morphogenesis in renal epithelial cells. JBC. 2006, 6; 281(1): 137-44
- Karihaloo A, Karumanchi SA, Cantley WL, Venkatesha S, Cantley LG, and Kale S. VEGF Induces Branching Morphogenesis/Tubulogenesis in Renal Epithelial Cells in a Neuropilin Dependent Fashion. Mol Cell Biol. 2005, 25(17); 7441-8