Anil Karihaloo, PhD

Research Interests

Nephrology; Developmental Biology

Research Organizations

Internal Medicine: Nephrology

Office of Cooperative Research

Research Summary

Our laboratory is currently interested in understanding how G-protein coupled chemokine receptor Cxcr4 modulates kidney development and fibrosis

Extensive Research Description

My laboratory is currently interested in determining what role chemokine receptor Cxcr4 plays in a developing and in an adult kidney. Cxcr4 is a seven-transmembrane G-protein coupled receptor protein known for its co-receptor activity for HIV-I and stem-cell homing. Its role in a developing kidney is only now being studied, partly because the Cxcr4 null mice die in-utero.Our laboratory has recently determined that it is also expressed in epithelial compartments of a developing and adult kidney. We observed that Cxcr4 positively contributes to ureteric-bud branching and may be involved in mesenchymal-to-epithelial transition (MET).
We also determining its potential involvement in the progression of renal fibrosis.

1. Understanding role of chemokine receptor, Cxcr4 in kidney development
2. Role of Cxcr4 in renal fibrosis

3. Determine whether a sub-population of Cxcr4 positive circulating myeloid cells can be used as biomarker for progressive chronic kidney disease

Selected Publications

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Contact Info

Anil Karihaloo, PhD
Mailing Address
Internal MedicinePO Box 208056
333 Cedar Street

New Haven, CT 06520-8056