Albert C Shaw, MD, PhD

Associate Professor of Medicine (Infectious Diseases)

Research Organizations


Internal Medicine: Infectious Diseases

Research Summary

Research in the Shaw laboratory is directed toward understanding the mechanisms underlying the functional decline of the immune system with aging. Ongoing projects include studies on the function of presenilins—proteins implicated in the pathogenesis of Alzheimer's Disease—in cells of the immune system. In addition, the laboratory is examining the role of mammalian topoisomerases in the control of DNA repair, genomic stability and age-related alterations in the immune system. Finally, we are engaged in ongoing studies in humans that seek to elucidate age-related changes in the innate immune system (such as the Toll-like receptors), and to correlate such changes with responsiveness to vaccines (which decreases substantially in older adults) and susceptibility to infectious diseases.

Selected Publications

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Contact Info

Albert C Shaw, MD, PhD
Patient Care Location
Yale-New Haven Hospital
20 York Street

New Haven, CT 06510
Mailing Address
PO Box 208022
300 Cedar Street

New Haven, CT 06520-8022