Erol Fikrig, MD

Waldemar Von Zedtwitz Professor of Medicine (Infectious Diseases) and Professor of Epidemiology (Microbial Diseases) and of Microbial Pathogenesis; Investigator, Howard Hughes Medical Institute; Section Chief, Infectious Diseases

Research Interests

Bacteria; Epidemiology; Lyme Disease; Parasitology; Public Health; Ticks; Viruses; West Nile virus; Global Health; Ehrlichiosis; Borrelia burgdorferi; Infectious Disease Medicine

Public Health Interests

Lyme Disease; Tropical Diseases; West Nile Virus

Research Organizations


Internal Medicine: Infectious Diseases

Molecular Virology: Virology laboratories

School of Public Health: Parasitology Program

Skin Diseases Research Center, Yale

Research Summary

My laboratory investigates vector-borne diseases. Studies are directed toward understanding Lyme disease, Human granulocytic ehrlichiosis, and West Nile virus. Efforts on Lyme disease include exploring immunity to Borrelia burgdorferi, selective B. burgdorferi gene expression in vivo, and the immunobiology of Lyme arthritis. Human granulocytic ehrlichiosis is caused by a newly described pathogen, transmitted by Ixodes scapularis ticks, that persists within neutrophils.

We are investigating the molecular strategies that this pathogen uses to survive in polymorphonuclear leukocytes. West Nile virus can cause fatal encephalitis, and we seek to understand the pathogenesis of this emerging disease. Finally, we are also developing molecular approaches to prevent ticks from feeding on a mammalian host, thereby interfering with pathogen transmission.

Specialized Terms: Vector-borne diseases; Lyme disease; Human granulocytic ehrilichiosis; West Nile virus

Selected Publications

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Contact Info

Erol Fikrig, MD
Patient Care Location
Yale-New Haven Hospital
20 York Street

New Haven, CT 06510
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Office Location
The Anlyan Center
300 Cedar Street, Ste S525A

New Haven, CT 06519
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Mailing Address
PO Box 208031
300 Cedar Street

New Haven, CT 06520-8056