Research

Genetics research by the IBDGC is conducted in conjunction with the 6 Genetics Research Centers. These projects employ a variety of approaches to identify genetic variation that contribute to disease susceptibility; for example, candidate gene and pathway analyses. Additionally, Consortium projects aim to build risk models through understanding of genetic influence on variations in phenotypes and gene-environment interactions. The Consortium Analytic team is lead by Mark J. Daly (Broad).

A selection of recent publications are presented below.

Genetics Research Publications

• Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Anderson CA, Boucher G, et al, Nature Genetics 43: 246-52, 2011. PMID 21297633.
• Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's Disease susceptibility loci. Franke A, McGovern DP, et al, Nature Genetics 42:1118-25, 2010 PMID21102463.
• Ulcerative colitis–risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. Silverberg MS, Cho JH, et al, Nature Genetics 41: 216-20, 2009. PMID: 19122664, PMCID: PMC2652837.
• Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Barrett JC, Hansoul S, et al, Nature Genetics 40: 955-62, 2008. PMID: 18587394, PMCID: PMC2574810.
• Assessment of reliability and validity of IBD phenotyping within the National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK) IBD Genetics Consortium (IBDGC). Dassopoulos T, Nguyen GC, et al, Inflammatory Bowel Disease 13: 975-83, 2007. PMID: 17427244.
• A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Duerr RH, Taylor KD, et al, Science 314: 1461-63, 2006. PMID: 17068223.

Recent Review Articles by Members of the Consortium

• Genome-wide association studies: present status and future directions. Cho JH. Gastroenterology 138: 1668-1672, 2010. PMID 20302866
• Inflammatory bowel disease. Abraham C, Cho JH. New England Journal of Medicine 361: 2066-78, 2009. PMID: 19923578.
• The genetics and immunopathogenesis of inflammatory bowel disease. Cho JH. Nature Review Immunology 8: 458-66, 2008. PMID: 18500230.
• Genotype/phenotype correlations and implications for clinical practice. Silverberg MS. J Pediatric Gastroenterology and Nutrition 46: E4-5. 2008. PMID: 18354327.