Heather G Allore PhD

Associate Professor of Medicine (Geriatrics); Director, Yale Program on Aging Biostatistics Core

Research Interests

State transition models; Experimental design; Longitudinal methods; Missing data Methods; Marginal structural models; Latent class models; Trajectory models; Dynamic stochastic models; Joint models

Current Projects

Dr. Allore's current research includes functional and mobility disability in the elderly, differences in immune system function of between young and older persons, age–related macular degeneration, multiple morbidity analysis, and falls in the elderly. She is also developing a subdiscipline of biostatistics within the American Statistical Association that focuses on training and methodological development in geriatrics called “gerontologic biostatistics.” This discipline would train biostatisticians for conducting collaborative clinical research with geriatricians and gerontologists in elderly populations and provide the basis for the development new statistical methodology.

Research Summary

Dr. Allore's research is focused on issues related to the design and analysis of studies of multi-component interventions and the design and analysis of observational studies of multifactorial geriatric health conditions. Other areas of her applied research include developing strategies for handling missing data that frequently occurs in studies of older persons, applying extended Cox models for state transitions in geriatrics, such as frailty and disability that consist of multiple discrete states in which both onset and recovery are possible, and determining the mechanisms of action of an effective multi-component intervention. She has collaborated on several projects in immunology and is introducing new analytic methods to account for correlations among elements of the innate immune system. She developed a subdiscipline of biostatistics within the American Statistical Association that focuses on training and methodological development in Aging Research called "Gerontologic Biostatistics." This discipline trains biostatisticians for conducting collaborative clinical research with geriatricians and gerontologists in elderly populations and provide the basis for the development new statistical methodology. She served on the NIH Aging Systems and Geriatrics study section, VA Human Rights Committee, and CDC Special Emphasis study section. She has served as a reviewer and editorial board member for a variety of medical journals.


Selected Publications

  • Han L, Allore H, Murphy T, Gill T, Peduzzi P, Lin H. Dynamics of functional aging based on latent-class trajectories of activities of daily living. Ann Epidemiol. 2013; 23(2):87-92. PMID: 23305692
  • Gill TM, Murphy TE, Gahbauer EA, Allore HG. The Course of Disability Before and After a Serious Fall Injury. JAMA Intern Med. 2013
  • Chaudhry SI, Murphy TE, Gahbauer E, Sussman LS, Allore HG, Gill TM. Restricting Symptoms in the Last Year of Life: A Prospective Cohort Study. JAMA Intern Med. 2013 173(16):1534-40. PMID:23836056
  • Ning Y, McAvay G, Chaudhry S, Arnold A, Allore HG. Results Differ by Applying Distinctive Multiple Imputation Approaches on the Longitudinal Cardiovascular Health Study Data. Exp Aging Res. 2013; 39:(1):27-43
  • Panda A, Chen S, Shaw AC, Allore HG. Statistical Approaches for Analyzing Immunologic Data of Repeated Observations: A Practical Guide Journal of Immunological Methods. J Immunological Methods. 2013
  • Allore HG, Ning Y, Brandt C, Goulet J. Accounting for Hierarchical Structure in Veteran Health Administration Data: Differences in Healthcare Utilization between Men and Women Veterans. International J Statistics Med Res. 2013; 2:94-103.
  • Gill TM; Murphy TE; Gahbauer EA; Allore HG. Association of Injurious Falls With Disability Outcomes and Nursing Home Admissions in Community-Living Older Persons. Am J Epid. 2013; 178(3):418-25.
  • Tinetti ME, McAvary GJ, Murphy TE, Gross CP, Lin H, Allore HG. Contribution Of Individual Diseases To Death In Older Adults With Multiple Diseases. 2012. J Am Geriatr Soc. 60(8):1448-56.
  • Murphy TE, McAvay G, Carriero NJ, Gross CP, Tinetti ME, Allore HG, Lin H. Deaths Observed in Medicare Beneficiaries: Average Attributable Fraction and its Longitudinal Extension for Many Diseases. 2012. Statistics in Medicine. PMIC: 22415597
  • Lin H, Allore HG, McAvay G, Tinetti ME, Gill TM, Gross CP, Murphy TE. A Method for Partitioning the Attributable Fraction of Multiple Time-Dependent Co-existing Risk Factors for an Adverse Health Outcome. Amer J Public Health. 2012 PMID:22515873

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