Research is centered on brain glucose sensing; the mechanisms responsible for defective glucose counterregulation in diabetes; development of a closed loop mechanical pancreas; the immunopathogenesis of autoimmune diabetes; and the development and implementation of immunomodulatory treatments for type 1 diabetes.
We have a wide variety of individual research mentors both within the Endocrinology Section and in other Departments. Below, we list each faculty member and include a short description of their research programs.
We have organized this list based on the three broad research interests of the Endocrinology Program:
Research in this program spans a variety of topics including the mechanisms of insulin resistance and signaling; the coupling of metabolism to insulin secretion in beta-cells; in vivo imaging of islets, the molecular mechanisms regulating glucose transport; the development of insulin resistance and diabetes in adolescents; the regulation of appetite and obesity; and the outcome of vascular disease in diabetics.
Research by these investigators focuses on the biology of PTHrP in cartilage and mammary gland; bone cell biology; skeletal metabolism and osteoporosis; calcium metabolism during lactation and the transport of calcium into milk; the role of dietary protein in calcium and bone metabolism; and the pathogenesis and treatment of disorders of phosphate metabolism, especially X-linked hypophosphatemic rickets.