Research


Research is one of the cornerstones of our Section. Our Section currently has over $8 million per year in research funding from NIDDK, more than any other Digestive Diseases Section in the country. Our faculty are engaged in a wide range of both basic laboratory research activities and patient-oriented clinical research. Details of an investigators work can be found through links on our faculty menu.

Major areas of laboratory research include:

Major areas of clinical research include:

  • complications and treatment of cirrhosis (Drs. Roberto Groszmann, Guadalupe Garcia-Tsao), viral hepatitis (Dr. Joe Lim), liver cancer (Dr. Mario Strazzabosco), and IBD (Drs. Judy Cho and Deborah Proctor),
  • motility disorders of the esophagus, optimal application of advanced endoscopic techniques to clinical problems including gastrointestinal bleeding, graft-versus-host disease and pancreatic biliary disorders (Dr. Harry Aslanian),
  • advanced endoscopic techniques; pancreatitis; sphincter of oddi dysfunction as well as other clinical aspects of biliary and pancreatic disease (Dr. Priya Jamidar),
  • endoscopic outcomes research (Dr. Anil Nagar),
  • diverticulitis (Dr. Martin Floch), and
  • newer endoscopic modalities (Dr. Caroline Loeser).

Related programs include: 

Abraham, Clara

Associate Professor of Medicine (Digestive Diseases)

Research Interests: Regulation of the intestinal immune system; T cell trafficking and activation; Genetics and immunobiology of inflammatory bowel disease; host:microbe interactions.

Aslanian, Harry Robert

Associate Professor of Medicine (Digestive Diseases)
Associate Director, Endoscopy
Director, Yale Advanced Endoscopy Fellowship
Director of Gastroenterology, Yale Health Plan

Research Interests: Advanced endoscopic techniques; Gastrointestinal bleeding; Colonoscopic polyp detection; Evaluation of pancreas cysts; Diagnosis of pancreas cancer; Pancreatic and biliary disorders; Therapy of bile duct obstruction via ERCP; Endoscopic ultrasound (EUS); Fine-needle aspiration (FNA); Advanced endoscopic imaging; Sedation for endoscopy

Binder, Henry J.

Professor Emeritus of and Senior Research Scientist in Medicine (Digestive Diseases)

Research Interests: ATPase; Colonic Electrolyte Transport; Epithelial Cell Function; Ion Transport; Short Chain Fatty Acids; Molecular Cellular Entities; Receptors

Boyer, James Lorenzen

Ensign Professor of Medicine (Digestive Diseases)
Emeritus Director, Yale Liver Center

Research Interests: Membrane transport; Bile formation; Cholestasis; Nuclear receptors; Bile acids; Membrane targeting; Jaundice; Autoimmune hepatitis; Primary biliary cirrhosis; Sclerosing cholangitis; Hepatic drug toxicity

Cho, Judy H

Professor (Adjunct) of Medicine (Digestive Diseases)
Director, Inflammatory Bowel Disease Center

Research Interests: Inflammatory Bowel Disease (IBD); identifying genetic variation that affects susceptibility to and expression of Inflammatory Bowel Disease (IBD)

Chung, Chuhan

Associate Professor of Medicine (Digestive Diseases)

Research Interests: Fatty Liver Disease; Hepatocellular Carcinoma; Angiogenic inhibitors; Pigment Epithelium-Derived Factor (PEDF); Thrombospondin-1

Floch, Martin Herbert

Assistant Clinical Professor of Medicine (Digestive Diseases)

Garcia-Tsao, Guadalupe

Professor of Medicine (Digestive Diseases)
Chief, Digestive Diseases, VA-CT Healthcare System
Director, Clinical and Translational Core, Yale Liver Center
Program Director, VA-CT Hepatitis C Resource Center

Research Interests: Cirrhosis; Natural history of cirrhosis; Gastroesophageal varices; Variceal hemorrhage; Ascites; Spontaneous bacterial peritonitis; Hepatorenal syndrome

Gorelick, Fred

Professor of Medicine (Digestive Diseases) and of Cell Biology
Deputy Director, Yale M.D., Ph.D. Program

Research Interests: Exocrine pancreas; Pancreatitis; Intracellular proteolysis; Vacuolar ATPase; AMPK; Protein kinase C

Groszmann, Roberto J

Professor Emeritus of Medicine (Digestive Diseases)

Research Interests: Ascites; Cirrhosis; Portal Hypertension; Variceal Bleeding

Iwakiri, Yasuko

Associate Professor of Medicine (Digestive Diseases)

Research Interests: Portal hypertension; Nitric oxide; S-nitrosylation; CD147 (EMMPRIN, Basigin); Reticulon 4B (Nogo-B); Liver fibrosis; Liver regeneration; Vascular biology

Jamidar, Priya Arvind

Professor of Medicine (Digestive Diseases)
Director, Endoscopy

Research Interests: Optimal application of advanced endoscopic techniques to clinical problems; Gastrointestinal bleeding; Graft-versus-host disease, pancreatic and biliary disorders

Lim, Joseph K

Associate Professor of Medicine (Digestive Diseases)
Director, Yale Viral Hepatitis Program

Research Interests: Acute and chronic liver diseases; Chronic hepatitis B and C infections; Fatty liver disorders, including non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH); Complications of cirrhosis and portal hypertension

Loeser, Caroline Seton

Assistant Clinical Professor of Medicine (Digestive Diseases)

Research Interests: Endoscopic imaging including confocal endomicroscopy

Mehal, Wajahat Zafar

Associate Professor of Medicine (Digestive Diseases)

Research Interests: Sterile inflammation; Liver fibrosis; Liver immunology

Nagar, Anil Bernard

Associate Professor of Medicine (Digestive Diseases)
Endoscopy Director, West Haven VAMC

Research Interests: Value of interventions for detecting and treating GI diseases

Nathanson, Michael Harris

Professor of Medicine (Digestive Diseases) and of Cell Biology
Section Chief, Digestive Diseases
Director, Yale Liver Center
Director, Center for Cell and Molecular Imaging

Research Interests: Mechanisms and effects of calcium signals in polarized epithelia; Effect of spatial organization of calcium signals on organ function regulation; Factors that organize Ca2+ waves in hepatocytes; Organization and effects of Ca2+ waves in cholangiocytes; Mechanisms and effects of Ca2+ signals in the nucleus

Proctor, Deborah Denise

Professor of Medicine (Digestive Diseases)
Medical Director, Inflammatory Bowel Disease Program
Site Director, Universidad del Valle, Cali, Columbia and Yale/Stanford, Johnson and Johnson Global Health Scholar Program
Board of Directors and Treasurer, Honduras Children's Project

Research Interests: Inflammatory Bowel Disease; Crohn's Disease; Ulcerative Colitis; Hereditary Hemorrhagic Telangiectasia

Strazzabosco, Mario

Professor (Adjunct) of Medicine (Digestive Diseases)
Director, Transplant Hepatology

Research Interests: Epithelial Cell Biology, Pathophysiology of Diseases of the Biliary Tree, Liver Cell Therapy, Treatment of Liver Cancer

Taddei, Tamar Hamosh

Associate Professor of Medicine (Digestive Diseases)

Research Interests: Clinical, translational, and outcome research on hepatocellular carcinoma