James J Farrell MD

Associate Professor of Medicine (Digestive Diseases); Director, Yale Center for Pancreatic Diseases

Departments & Organizations

Cancer Center, Yale: Gastrointestinal Cancer Program | Thoracic Oncology Program | Developmental Therapeutics

Internal Medicine: Digestive Diseases: Interventional Endoscopy Program

Research Interests

Pancreatic Cancer Early Diagnosis; Pancreatic Cystic Neoplasms, Pancreatic Biomarkers, Personalized Medicine, Pancreatic Disease, Gastrointestinal Oncoloy  more...


  • M.B.Ch.B., University College, Dublin, Ireland, 1992

Selected Publications

  • Farrell JJ, Toste P, Wu N, Li L, Wong J, Malkhassian D, Tran LM, Wu X, Li X, Dawson D, Wu H, Donahue TR. Endoscopically Acquired Pancreatic Cyst Fluid MicroRNA 21 and 221 Are Associated With Invasive Cancer. Am J Gastroenterol. 2013 Jun 11 Farrell JJ, Fernandez-del Castillo C. Pancreatic Cystic Neoplasms: Management and Unanswered Questions. Gastroenterology. 2013 Jun;144(6):1303-15 Canto MI, Hruban RH, Fishman E, Kamel IR, Schulick R, Zhang Z, Topazian M, Takahashi N, Petersen G, Klein AP, Axilbund J , Griffin C, Syngal S, Saltzman J, Mortele K, Lee J, Tamm E, Vikram R, Bliss S, Margolis D, Farrell JJ, Goggins M. Screening for prevalent early pancreatic neoplasia in high risk individuals: A prospective multicenter blinded study of EUS, CT and MRI.( Gastroenterology, 2012) Farrell JJ, Zhang L, Zhou H, Chia D, Elashoff D, Akin D, Paster BJ, Joshipura K ,Wong DT. Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer. Gut. 2011 Oct 12 Farrell JJ, Hecht, JR; Senzer N, Nemunaitis J, Rosemurgy A, Chung T, Hanna N, Chang K, Javle M, Posner M, Waxman I, Reid A, Erickson R, Canto M, Chak A, Blatner G, Kovacevic M, Thornton M. A Phase I/II, Endoscopic ultrasound or Percutaneous Intratumoral TNFerade Biologic with 5-FU and Radiation Therapy for First-Line Treatment of Unresectable Locally Advanced Pancreatic Cancer. Gastrointest Endosc. 2012 Feb;75(2):332-8. Farrell JJ Garcia M, Elshimali YI, Guha C, Dicker A, Elsaleh H Cytidine Deaminase Single Nucleotide Polymorphism is Predictive of Toxicity from Gemcitabine in Patients with Pancreatic Cancer. The Pharmacogenomics Journal 2011 May 31 Weinberg B, Spiegel B, Tomlinson J, Farrell JJ. Asymptomatic Pancreatic Cysts: Maximizing Survival and Quality of Life using Markov-based Clinical Nomograms Gastroenterology 2010Feb;138(2):531-40 Farrell JJ, Elsaleh H, Garcia M, Lai R, Ammar A, Regine W, Abrams R, Bowen Benson A, Macdonald J, Cass CA, Mackey JA..Human ENT1 is predictive of response to gemcitabine treatment in patients with pancreatic cancer: Results from the RTOG 9704 Prospective Randomized Trial. Gastroenterology 2009 Jan;136(1):187-95



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