David Assis, MD

Assistant Professor of Medicine (Digestive Diseases)

Research Interests

Autoimmune Diseases; Hepatitis

Public Health Interests

Hepatitis

Research Organizations

Digestive Diseases

HTI

Research Summary

I am evaluating the role of an inflammatory protein called MIF in autoimmune hepatitis and its ability to be a predictor of disease severity, response to therapy, and a predictor of disease relapse.

I am evaluating alternative therapies for the treatment of Primary Sclerosing Cholangitis.

Extensive Research Description

I am investigating the role of macrophage migration inhibitory factor (MIF) in autoimmune hepatitis. Active studies involve serial measurement of serum MIF and its soluble receptor (CD74) in the blood of patients with autoimmune hepatitis, to evaluate if these proteins can serve as biomarkers of disease activity.

I am evaluating cellular mechanisms of the release of the CD74 protein and its neutralizing activity on the cytokine MIF.

I am investigating the role of MIF in the pathophysiology of autoimmune hepatitis in animal models of disease.

I am evaluating alternative therapies for Primary Sclerosing Cholangitis (PSC) including all-trans retinoic acid and fenofibrate.

A study of the role of macrophage migration inhibitory factor (MIF) in autoimmune hepatitis, through clinical and translational investigations.

A study of the role of all-trans retinoic acid (ATRA) for the treatment of Primary Sclerosing Cholangitis (PSC), in collaboration with Dr. James Boyer.

Selected Publications

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Contact Info

David Assis, MD
Patient Care Locations
Yale Digestive DiseasesTemple Medical Center
40 Temple Street, Ste Suite 1A

New Haven, CT 06510
Yale Health Center
55 Lock Street

New Haven, CT 06511
Yale-New Haven Hospital
20 York Street

New Haven, CT 06510
Mailing Address
PO Box 208019
New Haven, CT 06520-8019