Viral Hepatitis Program


The Yale Viral Hepatitis Program (YVHP) is a multidisciplinary group of physicians and health providers who are committed to the care and management of acute and chronic viral hepatitis by integrating the breadth of Yale’s expertise in patient care, education, and clinical and laboratory research. Since its origins Yale Digestive Diseases has sustained a 50-year tradition of excellence in liver research and patient care, and continues to bear a national and international influence on the study and treatment of liver disorders. As a partner of the Yale Liver Center (YLC)—one of only four NIH-sponsored liver research centers in the United States— it is the only center in Connecticut that offers comprehensive patient care for individuals with viral hepatitis.

The key to effective disease management of acute and chronic viral hepatitis is coordinated care among specialty trained physicians. The YVHP has close relationships with specialists in adult and pediatric gastroenterology, transplant hepatology, medical and transplant nephrology, transplant surgery, gastrointestinal pathology, diagnostic and interventional radiology, gastrointestinal surgery, rheumatology, OB/GYN, medical and surgical oncology, infectious diseases, the AIDS Care Program, psychiatry, and addiction medicine.

The Gastrointestinal Pathology program at Yale is the only subspecialty program in Connecticut, and provides expert consultative services for the most challenging liver pathology examinations in the region. The YVHP partners with Yale’s Nathan Smith Clinic in the management of patients with HBV/HIV and HCV/HIV co-infections, and with the Yale Liver Transplant Program in the pre and post-transplant evaluation and management of patients with liver cirrhosis and end-stage liver disease.

The YVHP has four strategic arms, including:

  • Education – providing formal education classes and individualized instruction sessions for patients with chronic hepatitis C infection prior to the initiation of antiviral therapy
  • Treatment – maintaining strict standards of practice in treatment protocols and close coordination of care with referring physicians to provide the most advanced and scientifically based approaches to the management of viral hepatitis
  • Research – ensuring the opportunity for patient access to novel approaches in the treatment of viral hepatitis and liver disorders through clinical trials
  • Community Outreach – building relationships with the surrounding communities of Greater New Haven and Connecticut to raise awareness about viral hepatitis, and to promote screening and education

Among special services offered by this program are the following:

  • Multidisciplinary patient care conferences held weekly
  • Multidisciplinary liver pathology conferences held weekly
  • Coordination with the liver and kidney transplantation programs
  • Comprehensive procedural services for diagnostic and interventional GI endoscopy, percutaneous and transjugular liver biopsy, paracentesis, and transjugular intrahepatic portosystemic shunt (TIPS)
  • Formal mental health assessment for pre-treatment and on-treatment monitoring of co-morbid psychiatric disease
  • Mindfulness-based cognitive therapy (MBCT)
  • Coordinated, individualized care of pediatric and adolescent patients
  • Non-invasive approaches to the assessment of liver fibrosis

Lim, Joseph K

Associate Professor of Medicine (Digestive Diseases); Director, Yale Viral Hepatitis Program


Altice, Frederick Lewis

Professor of Medicine (Infectious Diseases) and of Epidemiology (Microbial Diseases)
Director, Clinical and Community Research
Director, HIV in Prisons Program
Director, Community Health Care Van
Icon Professor of Medicine, University of Malaya-Centre of Excellence for Research in AIDS (CERiA)
Professor of Epidemiology and Public Health, Division of Epidemiology of Microbial Diseases

Clinical Interests:Infectious diseases; HIV/AIDS; Viral hepatitis (HBV, HCV) and Tuberculosis; Addiction Medicine (Opioid substitution therapy, Pharmacotherapy for alcohol dependence; Methamphetamine Abuse); Motivational Interviewing; Health Services Research; Implementation Science, Global Health, Health Policy, Epidemiology

Bruce, Robert Douglas

Associate Clinical Professor of Medicine (Infectious Diseases)

Clinical Interests:Substance Abuse/Dependence and Infectious Diseases; HIV; Hepatitis C; Evidence Based Treatments for Addiction and HIV

Eggers, Carol Andrea

Clinical Instructor in Nursing

Garcia-Tsao, Guadalupe

Professor of Medicine (Digestive Diseases)
Chief, Digestive Diseases, VA-CT Healthcare System
Director, Clinical and Translational Core, Yale Liver Center
Program Director, VA-CT Hepatitis C Resource Center

Clinical Interests:Cirrhosis and its complications; acute and chronic hepatitis; alcoholic liver disease; drug-induced hepatotoxicity; cholestatic liver disease, including primary biliary cirrhosis and primary sclerosing cholangitis

Jakab, Simona

Assistant Professor of Medicine (Digestive Diseases)

Clinical Interests:evaluation and treatment of patients with hepatitis B, C, fatty liver disease, drug-induced liver disease, cirrhosis; management of patients before and after liver transplantation, liver biopsy, large volume paracentesis; endoscopic evaluation and treatment of esophageal varices; colonoscopy for colorectal cancer screening; general endoscopic evaluation of the upper and lower gastrointestinal tract.

Kozal, Michael J

Professor of Medicine (AIDS)
Chief Section of Infectious Diseases VA CT Healthcare System
Director Yale HIV Clinical Trials
Acting Chief, Medical Service VACHS & Vice Chair, VA Medical Service for the Yale Dept. of Internal Medicine

Clinical Interests:Infectious diseases; AIDS care; HIV care

Lim, Joseph K

Associate Professor of Medicine (Digestive Diseases)
Director, Yale Viral Hepatitis Program

Clinical Interests:Liver disorders; viral hepatitis B and C; fatty liver disorders; obesity; liver cancer; primary biliary cirrhosis; autoimmune hepatitis; liver disorders of pregnancy; primary sclerosing cholangitis; alcoholic liver disease; hemochromatosis; Wilson's disease; medication-induced hepatotoxicity

Mehal, Wajahat Zafar

Associate Professor of Medicine (Digestive Diseases)
Director Yale Metabolic Health and Weight Loss Program

Clinical Interests:Multidisciplinary management of non-alcoholic hepatitis and liver fibrosis, including an integrated weight loss program. Inpatient care related to general gastroenterology and endoscopic procedures.

Mistry, Pramod Kumar

Professor of Medicine (Digestive Diseases) and of Pediatrics (Gastroenterology)
Professor of Cellular & Molecular Physiology
Director of Yale Lysosomal Disease Center and Gaucher Disease Treatment Center

Clinical Interests:Lysosomal Storage Diseases; Gaucher disease; Fabry disease; Pompe Disease; MPS; Cholesterol ester storage disease; Wilson's disease; Adult genetic liver diseases; Hemochromatosis; alpha 1 antitrypsin deficiency Nonalcoholic Steatohepatitis (NASH).

Robert, Marie E

Professor of Pathology and of Medicine
Associate Director, Fellowship in Gastrointestinal Pathology

Clinical Interests:Gastrointestinal pathology; liver and pancreatic pathology; Barrett esophagus; gastritis; Inflammatory Bowel Disease (IBD); celiac disease; colitis; Crohn's disease; esophageal cancer; colon cancer; pancreatic cancer; hepatitis; liver tumors; dysplasia in Barrett esophagus; ulcerative colitis

Schilsky, Michael

Associate Professor of Medicine (Digestive Diseases) and of Surgery (Transplant)
Medical Director, Adult Liver Transplant at Yale-New Haven Transplantation Center

Clinical Interests:Liver transplant; acute liver failure; cirrhosis; inherited metabolic disorders of the liver; Wilson disease; iron overload disorders; hemochromatosis; alpha-1 antitrypsin disease

Strazzabosco, Mario

Professor (Adjunct) of Medicine (Digestive Diseases)
Director, Transplant Hepatology

Clinical Interests:liver transplantation; liver cancer; liver cirrhosis; biliary tract diseases and cholestasis; primary biliary cirrhosis; primary sclerosing cholangitis

Taddei, Tamar Hamosh

Associate Professor of Medicine (Digestive Diseases)

Clinical Interests:Liver cancer; benign and malignant neoplasms of the liver, cirrhosis and its complications; transplant hepatology

Villanueva, Merceditas Santos

Associate Professor of Medicine (AIDS)

Clinical Interests:infectious disease; HIV care