Viral Hepatitis Program


The Yale Viral Hepatitis Program (YVHP) is a multidisciplinary group of physicians and health providers who are committed to the care and management of acute and chronic viral hepatitis by integrating the breadth of Yale’s expertise in patient care, education, and clinical and laboratory research. Since its origins Yale Digestive Diseases has sustained a 50-year tradition of excellence in liver research and patient care, and continues to bear a national and international influence on the study and treatment of liver disorders. As a partner of the Yale Liver Center (YLC)—one of only four NIH-sponsored liver research centers in the United States— it is the only center in Connecticut that offers comprehensive patient care for individuals with viral hepatitis.

The key to effective disease management of acute and chronic viral hepatitis is coordinated care among specialty trained physicians. The YVHP has close relationships with specialists in adult and pediatric gastroenterology, transplant hepatology, medical and transplant nephrology, transplant surgery, gastrointestinal pathology, diagnostic and interventional radiology, gastrointestinal surgery, rheumatology, OB/GYN, medical and surgical oncology, infectious diseases, the AIDS Care Program, psychiatry, and addiction medicine.

The Gastrointestinal Pathology program at Yale is the only subspecialty program in Connecticut, and provides expert consultative services for the most challenging liver pathology examinations in the region. The YVHP partners with Yale’s Nathan Smith Clinic in the management of patients with HBV/HIV and HCV/HIV co-infections, and with the Yale Liver Transplant Program in the pre and post-transplant evaluation and management of patients with liver cirrhosis and end-stage liver disease.

The YVHP has four strategic arms, including:

  • Education – providing formal education classes and individualized instruction sessions for patients with chronic hepatitis C infection prior to the initiation of antiviral therapy
  • Treatment – maintaining strict standards of practice in treatment protocols and close coordination of care with referring physicians to provide the most advanced and scientifically based approaches to the management of viral hepatitis
  • Research – ensuring the opportunity for patient access to novel approaches in the treatment of viral hepatitis and liver disorders through clinical trials
  • Community Outreach – building relationships with the surrounding communities of Greater New Haven and Connecticut to raise awareness about viral hepatitis, and to promote screening and education

Among special services offered by this program are the following:

  • Multidisciplinary patient care conferences held weekly
  • Multidisciplinary liver pathology conferences held weekly
  • Coordination with the liver and kidney transplantation programs
  • Comprehensive procedural services for diagnostic and interventional GI endoscopy, percutaneous and transjugular liver biopsy, paracentesis, and transjugular intrahepatic portosystemic shunt (TIPS)
  • Formal mental health assessment for pre-treatment and on-treatment monitoring of co-morbid psychiatric disease
  • Mindfulness-based cognitive therapy (MBCT)
  • Coordinated, individualized care of pediatric and adolescent patients
  • Non-invasive approaches to the assessment of liver fibrosis
Bio Profile

Joseph K Lim

Associate Professor of Medicine (Digestive Diseases)

Director, Yale Viral Hepatitis Program

Bio Profile

Frederick Lewis Altice

Professor of Medicine (Infectious Diseases) and of Epidemiology (Microbial Diseases)

Director, Clinical and Community Research

Director, HIV in Prisons Program

Director, Community Health Care Van

Icon Professor of Medicine, University of Malaya-Centre of Excellence for Research in AIDS (CERiA)

Professor of Epidemiology and Public Health, Division of Epidemiology of Microbial Diseases

Clinical Interests

Adult; Alcohol Drinking; Communicable Diseases; HIV; Sexually Transmitted Diseases; Substance-Related Disorders

Bio Profile

Robert Douglas Bruce

Associate Clinical Professor of Medicine (Infectious Diseases)

Bio Profile

Hong Chau

"Research Associate II, Clinical Research Coordinator"

Clinical Interests

Gastroenterology; Digestive System Processes

Bio Profile

Carol Andrea Eggers

Clinical Instructor in Nursing

Bio Profile

Guadalupe Garcia-Tsao

Professor of Medicine (Digestive Diseases)

Chief, Digestive Diseases, VA-CT Healthcare System

Director, Clinical and Translational Core, Yale Liver Center

Program Director, VA-CT Hepatitis C Resource Center

Clinical Interests

Hepatitis; Liver Diseases

Bio Profile

Simona Simona Jakab

Assistant Professor of Medicine (Digestive Diseases)

Bio Profile

Michael J Kozal

Professor of Medicine (AIDS)

Chief Section of Infectious Diseases VA CT Healthcare System

Director Yale HIV Clinical Trials

Acting Chief, Medical Service VACHS & Vice Chair, VA Medical Service for the Yale Dept. of Internal Medicine

Clinical Interests

HIV; Sexually Transmitted Diseases

Bio Profile

Joseph K Lim

Associate Professor of Medicine (Digestive Diseases)

Director, Yale Viral Hepatitis Program

Clinical Interests

Gastroenterology; Hepatitis; Hepatitis B; Hepatitis, Viral, Human; Hepatitis C; Hypertension, Portal; Liver Diseases; Obesity; Non-alcoholic Fatty Liver Disease

Bio Profile

Wajahat Zafar Mehal

Associate Professor of Medicine (Digestive Diseases)

Director of Yale Weight Loss Program