Publications

2015

1.

Cardiomyopathy and Worsened Ischemic Heart Failure in SM22-α Cre-Mediated Neuropilin-1 Null Mice: Dysregulation of PGC1α and Mitochondrial Homeostasis.

Wang Y, Cao Y, Yamada S, Thirunavukkarasu M, Nin V, Joshi M, Rishi MT, Bhattacharya S, Camacho-Pereira J, Sharma AK, Shameer K, Kocher JP, Sanchez JA, Wang E, Hoeppner LH, Dutta SK, Leof EB, Shah V, Claffey KP, Chini EN, Simons M, Terzic A, Maulik N, Mukhopadhyay D.

Arterioscler Thromb Vasc Biol. 2015 Jun;35 (6) :1401-12. Epub 2015 Apr 16. PMID: 25882068

2.

Arterial specification of endothelial cells derived from human induced pluripotent stem cells in a biomimetic flow bioreactor.

Sivarapatna A, Ghaedi M, Le AV, Mendez JJ, Qyang Y, Niklason LE.

Biomaterials. 2015 Jun;53 :621-33. Epub 2015 Mar 24. PMID: 25890758

3.

State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization: A Scientific Statement From the American Heart Association.

Simons M, Alitalo K, Annex BH, Augustin HG, Beam C, Berk BC, Byzova T, Carmeliet P, Chilian W, Cooke JP, Davis GE, Eichmann A, Iruela-Arispe ML, Keshet E, Sinusas AJ, Ruhrberg C, Woo YJ, Dimmeler S.

Circ Res. 2015 May 22;116 (11) :e99-e132. Epub 2015 Apr 30. PMID: 25931450

4.

New targets to treat obesity and the metabolic syndrome.

Martin K, Mani M, Mani A.

Eur J Pharmacol. 2015 May 19; Epub 2015 May 19. PMID: 26001373

5.

Phosphorylation of GATA-6 is required for vascular smooth muscle cell differentiation after mTORC1 inhibition.

Xie Y, Jin Y, Merenick BL, Ding M, Fetalvero KM, Wagner RJ, Mai A, Gleim S, Tucker DF, Birnbaum MJ, Ballif BA, Luciano AK, Sessa WC, Rzucidlo EM, Powell RJ, Hou L, Zhao H, Hwa J, Yu J, Martin KA.

Sci Signal. 2015 May 12;8 (376) :ra44. Epub 2015 May 12. PMID: 25969542

6.

Molecular Controls of Arterial Morphogenesis.

Simons M, Eichmann A.

Circ Res. 2015 May 8;116 (10) :1712-1724. PMID: 25953926

7.

Haptoglobin enhances cardiac transplant rejection.

Shen H, Heuzey E, Mori DN, Wong CK, Colangelo CM, Chung LM, Bruce C, Slizovskiy IB, Booth CJ, Kreisel D, Goldstein DR.

Circ Res. 2015 May 8;116 (10) :1670-9. Epub 2015 Mar 23. PMID: 25801896

8.

Efficient Gene Disruption in Cultured Primary Human Endothelial Cells by CRISPR/Cas9.

Abrahimi P, Chang WG, Kluger MS, Qyang Y, Tellides G, Saltzman M, Pober JS.

Circ Res. 2015 May 4; Epub 2015 May 4. PMID: 25940550

9.

KRAS and Guanine Nucleotide-Binding Protein Mutations in Pancreatic Juice Collected From the Duodenum of Patients at High Risk for Neoplasia Undergoing Endoscopic Ultrasound.

Eshleman JR, Norris AL, Sadakari Y, Debeljak M, Borges M, Harrington C, Lin E, Brant A, Barkley T, Almario JA, Topazian M, Farrell J, Syngal S, Lee JH, Yu J, Hruban RH, Kanda M, Canto MI, Goggins M.

Clin Gastroenterol Hepatol. 2015 May;13 (5) :963-969.e4. Epub 2014 Dec 4. PMID: 25481712

10.

Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization.

Rama N, Dubrac A, Mathivet T, Ní Chárthaigh RA, Genet G, Cristofaro B, Pibouin-Fragner L, Ma L, Eichmann A, Chédotal A.

Nat Med. 2015 May;21 (5) :483-91. Epub 2015 Apr 20. PMID: 25894826

11.

When it is better to regress: dynamics of vascular pruning.

Ricard N, Simons M.

PLoS Biol. 2015 May;13 (5) :e1002148. Epub 2015 May 15. PMID: 25978860

12.

Nonalcoholic fatty liver disease induced by noncanonical Wnt and its rescue by Wnt3a.

Wang S, Song K, Srivastava R, Dong C, Go GW, Li N, Iwakiri Y, Mani A.

FASEB J. 2015 Apr 27; Epub 2015 Apr 27. PMID: 25917329

13.

DAP12 Expression in Lung Macrophages Mediates Ischemia/Reperfusion Injury by Promoting Neutrophil Extravasation.

Spahn JH, Li W, Bribriesco AC, Liu J, Shen H, Ibricevic A, Pan JH, Zinselmeyer BH, Brody SL, Goldstein DR, Krupnick AS, Gelman AE, Miller MJ, Kreisel D.

J Immunol. 2015 Apr 15;194 (8) :4039-48. Epub 2015 Mar 11. PMID: 25762783

14.

Rac1 functions as a reversible tension modulator to stabilize VE-cadherin trans-interaction.

Daneshjou N, Sieracki N, van Nieuw Amerongen GP, Conway DE, Schwartz MA, Komarova YA, Malik AB.

J Cell Biol. 2015 Apr 13;209 (1) :181. Epub 2015 Apr 6. PMID: 25847538

15.

Role of Mechanotransduction in Vascular Biology: Focus on Thoracic Aortic Aneurysms and Dissections.

Humphrey JD, Schwartz MA, Tellides G, Milewicz DM.

Circ Res. 2015 Apr 10;116 (8) :1448-1461. PMID: 25858068

16.

Endothelial glucocorticoid receptor suppresses atherogenesis--brief report.

Goodwin JE, Zhang X, Rotllan N, Feng Y, Zhou H, Fernández-Hernando C, Yu J, Sessa WC.

Arterioscler Thromb Vasc Biol. 2015 Apr;35 (4) :779-82. Epub 2015 Feb 19. PMID: 25810297

17.

Epigenetic regulation of smooth muscle cell plasticity.

Liu R, Leslie KL, Martin KA.

Biochim Biophys Acta. 2015 Apr;1849 (4) :448-453. Epub 2014 Jun 15. PMID: 24937434

18.

Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex.

Coon BG, Baeyens N, Han J, Budatha M, Ross TD, Fang JS, Yun S, Thomas JL, Schwartz MA.

J Cell Biol. 2015 Mar 30;208 (7) :975-86. Epub 2015 Mar 23. PMID: 25800053

19.

Endothelial cell metabolism in normal and diseased vasculature.

Eelen G, de Zeeuw P, Simons M, Carmeliet P.

Circ Res. 2015 Mar 27;116 (7) :1231-44. PMID: 25814684

20.

Hyperglycemia repression of miR-24 coordinately upregulates endothelial cell expression and secretion of Von Willebrand Factor.

Xiang Y, Cheng J, Wang D, Hu X, Xie Y, Stitham J, Atteya G, Du J, Tang WH, Lee SH, Leslie K, Spollett G, Liu Z, Herzog E, Herzog RI, Lu J, Martin KA, Hwa J.

Blood. 2015 Mar 26; Epub 2015 Mar 26. PMID: 25814526

21.

ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation.

Tornavaca O, Chia M, Dufton N, Almagro LO, Conway DE, Randi AM, Schwartz MA, Matter K, Balda MS.

J Cell Biol. 2015 Mar 16;208 (6) :821-38. Epub 2015 Mar 9. PMID: 25753039

22.

Vascular endothelial growth factor receptor 3 controls neural stem cell activation in mice and humans.

Han J, Calvo CF, Kang TH, Baker KL, Park JH, Parras C, Levittas M, Birba U, Pibouin-Fragner L, Fragner P, Bilguvar K, Duman RS, Nurmi H, Alitalo K, Eichmann AC, Thomas JL.

Cell Rep. 2015 Feb 24;10 (7) :1158-72. Epub 2015 Feb 19. PMID: 25704818

23.

Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point.

Baeyens N, Nicoli S, Coon BG, Ross TD, Van den Dries K, Han J, Lauridsen HM, Mejean CO, Eichmann A, Thomas JL, Humphrey JD, Schwartz MA.

Elife. 2015 Feb 2;4 Epub 2015 Feb 2. PMID: 25643397

24.

Molecular controls of lymphatic VEGFR3 signaling.

Deng Y, Zhang X, Simons M.

Arterioscler Thromb Vasc Biol. 2015 Feb;35 (2) :421-9. Epub 2014 Dec 18. PMID: 25524775

25.

Induced pluripotent stem cell-derived vascular smooth muscle cells: methods and application.

Dash BC, Jiang Z, Suh C, Qyang Y.

Biochem J. 2015 Jan 15;465 (2) :185-94. PMID: 25559088

26.

Restoration of impaired endothelial myocyte enhancer factor 2 function rescues pulmonary arterial hypertension.

Kim J, Hwangbo C, Hu X, Kang Y, Papangeli I, Mehrotra D, Park H, Ju H, McLean DL, Comhair SA, Erzurum SC, Chun HJ.

Circulation. 2015 Jan 13;131 (2) :190-9. Epub 2014 Oct 21. PMID: 25336633

27.

Rac1 functions as a reversible tension modulator to stabilize VE-cadherin trans-interaction.

Daneshjou N, Sieracki N, van Nieuw Amerongen GP, Schwartz MA, Komarova YA, Malik AB.

J Cell Biol. 2015 Jan 5;208 (1) :23-32. PMID: 25559184

28.

Up-regulation of thrombospondin-2 in Akt1-null mice contributes to compromised tissue repair due to abnormalities in fibroblast function.

Bancroft T, Bouaouina M, Roberts S, Lee M, Calderwood DA, Schwartz M, Simons M, Sessa WC, Kyriakides TR.

J Biol Chem. 2015 Jan 2;290 (1) :409-22. Epub 2014 Nov 11. PMID: 25389299

29.

Change of direction in the biomechanics of atherosclerosis.

Mohamied Y, Rowland EM, Bailey EL, Sherwin SJ, Schwartz MA, Weinberg PD.

Ann Biomed Eng. 2015 Jan;43 (1) :16-25. Epub 2014 Aug 20. PMID: 25138165

30.

Angiogenesis versus arteriogenesis: neuropilin 1 modulation of VEGF signaling.

Kofler NM, Simons M.

F1000Prime Rep. 2015;7 :26. Epub 2015 Mar 3. PMID: 25926977

31.

Integrin adjunct therapy for melanoma.

Andarawewa KL, Moissoglu K, Sup Lee C, Ando Y, Yu M, Debnath P, Shannon JD, Sirinivasan S, Conaway MR, Weber MJ, Schwartz MA.

Pigment Cell Melanoma Res. 2015 Jan;28 (1) :114-6. Epub 2014 Nov 3. PMID: 25264294

2014

1.

KRAS and Guanine Nucleotide-Binding Protein Mutations in Pancreatic Juice Collected From the Duodenum of Patients at High Risk for Neoplasia Undergoing Endoscopic Ultrasound.

Eshleman JR, Norris AL, Sadakari Y, Debeljak M, Borges M, Harrington C, Lin E, Brant A, Barkley T, Almario JA, Topazian M, Farrell J, Syngal S, Lee JH, Yu J, Hruban RH, Kanda M, Canto MI, Goggins M.

Clin Gastroenterol Hepatol. 2015 May;13 (5) :963-969.e4. Epub 2014 Dec 4. PMID: 25481712

2.

Epigenetic regulation of smooth muscle cell plasticity.

Liu R, Leslie KL, Martin KA.

Biochim Biophys Acta. 2015 Apr;1849 (4) :448-453. Epub 2014 Jun 15. PMID: 24937434

3.

Molecular controls of lymphatic VEGFR3 signaling.

Deng Y, Zhang X, Simons M.

Arterioscler Thromb Vasc Biol. 2015 Feb;35 (2) :421-9. Epub 2014 Dec 18. PMID: 25524775

4.

Restoration of impaired endothelial myocyte enhancer factor 2 function rescues pulmonary arterial hypertension.

Kim J, Hwangbo C, Hu X, Kang Y, Papangeli I, Mehrotra D, Park H, Ju H, McLean DL, Comhair SA, Erzurum SC, Chun HJ.

Circulation. 2015 Jan 13;131 (2) :190-9. Epub 2014 Oct 21. PMID: 25336633

5.

Up-regulation of thrombospondin-2 in Akt1-null mice contributes to compromised tissue repair due to abnormalities in fibroblast function.

Bancroft T, Bouaouina M, Roberts S, Lee M, Calderwood DA, Schwartz M, Simons M, Sessa WC, Kyriakides TR.

J Biol Chem. 2015 Jan 2;290 (1) :409-22. Epub 2014 Nov 11. PMID: 25389299

6.

Change of direction in the biomechanics of atherosclerosis.

Mohamied Y, Rowland EM, Bailey EL, Sherwin SJ, Schwartz MA, Weinberg PD.

Ann Biomed Eng. 2015 Jan;43 (1) :16-25. Epub 2014 Aug 20. PMID: 25138165

7.

Integrin adjunct therapy for melanoma.

Andarawewa KL, Moissoglu K, Sup Lee C, Ando Y, Yu M, Debnath P, Shannon JD, Sirinivasan S, Conaway MR, Weber MJ, Schwartz MA.

Pigment Cell Melanoma Res. 2015 Jan;28 (1) :114-6. Epub 2014 Nov 3. PMID: 25264294

8.

ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis.

Chang SH, Elemento O, Zhang J, Zhuang ZW, Simons M, Hla T.

Proc Natl Acad Sci U S A. 2014 Dec 23;111 (51) :18309-14. Epub 2014 Nov 24. PMID: 25422430

9.

Syndecan 4 is required for endothelial alignment in flow and atheroprotective signaling.

Baeyens N, Mulligan-Kehoe MJ, Corti F, Simon DD, Ross TD, Rhodes JM, Wang TZ, Mejean CO, Simons M, Humphrey J, Schwartz MA.

Proc Natl Acad Sci U S A. 2014 Dec 2;111 (48) :17308-13. Epub 2014 Nov 17. PMID: 25404299

10.

Pioglitazone for secondary prevention after ischemic stroke and transient ischemic attack: rationale and design of the Insulin Resistance Intervention after Stroke Trial.

Viscoli CM, Brass LM, Carolei A, Conwit R, Ford GA, Furie KL, Gorman M, Guarino PD, Inzucchi SE, Lovejoy AM, Parsons MW, Peduzzi PN, Ringleb PA, Schwartz GG, Spence JD, Tanne D, Young LH, Kernan WN.

Am Heart J. 2014 Dec;168 (6) :823-9.e6. Epub 2014 Jul 28. PMID: 25458644

11.

Individual variation of human S1P1 coding sequence leads to heterogeneity in receptor function and drug interactions.

Obinata H, Gutkind S, Stitham J, Okuno T, Yokomizo T, Hwa J, Hla T.

J Lipid Res. 2014 Dec;55 (12) :2665-75. Epub 2014 Oct 7. PMID: 25293589

12.

Mechanotransduction and extracellular matrix homeostasis.

Humphrey JD, Dufresne ER, Schwartz MA.

Nat Rev Mol Cell Biol. 2014 Dec;15 (12) :802-12. Epub 2014 Oct 22. PMID: 25355505

13.

Wnt signaling, de novo lipogenesis, adipogenesis and ectopic fat.

Song K, Wang S, Mani M, Mani A.

Oncotarget. 2014 Nov 30;5 (22) :11000-3. PMID: 25526027

14.

Discovery and characterization of small molecules that target the GTPase Ral.

Yan C, Liu D, Li L, Wempe MF, Guin S, Khanna M, Meier J, Hoffman B, Owens C, Wysoczynski CL, Nitz MD, Knabe WE, Ahmed M, Brautigan DL, Paschal BM, Schwartz MA, Jones DN, Ross D, Meroueh SO, Theodorescu D.

Nature. 2014 Nov 20;515 (7527) :443-7. Epub 2014 Sep 14. PMID: 25219851

15.

Lymphatic fate specification: an ERK-controlled transcriptional program.

Yu P, Tung JK, Simons M.

Microvasc Res. 2014 Nov;96 :10-5. Epub 2014 Aug 15. PMID: 25132472

16.

Development of the fetal bone marrow niche and regulation of HSC quiescence and homing ability by emerging osteolineage cells.

Coşkun S, Chao H, Vasavada H, Heydari K, Gonzales N, Zhou X, de Crombrugghe B, Hirschi KK.

Cell Rep. 2014 Oct 23;9 (2) :581-90. Epub 2014 Oct 9. PMID: 25310984

17.

The PAR complex controls the spatiotemporal dynamics of F-actin and the MTOC in directionally migrating leukocytes.

Crespo CL, Vernieri C, Keller PJ, Garrè M, Bender JR, Wittbrodt J, Pardi R.

J Cell Sci. 2014 Oct 15;127 (Pt 20) :4381-95. Epub 2014 Sep 1. PMID: 25179599

18.

The magic touch: endothelial cells muscle-up adipose.

Martin KA, Hirschi KK.

Circ Res. 2014 Oct 10;115 (9) :752-4. PMID: 25301822

19.

Mechanotransduction of shear stress occurs through changes in VE-cadherin and PECAM-1 tension: Implications for cell migration.

Conway DE, Schwartz MA.

Cell Adh Migr. 2014 Oct 3; :0. Epub 2014 Oct 3. PMID: 25482618

20.

Fox(y) regulators of VEGF receptors.

Ricard N, Simons M.

Circ Res. 2014 Sep 26;115 (8) :683-5. PMID: 25258399

21.

Fibroblast growth factor receptor 1 is a key inhibitor of TGFβ signaling in the endothelium.

Chen PY, Qin L, Tellides G, Simons M.

Sci Signal. 2014 Sep 23;7 (344) :ra90. Epub 2014 Sep 23. PMID: 25249657

22.

Chemokine-coupled β2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis.

Morrison AR, Yarovinsky TO, Young BD, Moraes F, Ross TD, Ceneri N, Zhang J, Zhuang ZW, Sinusas AJ, Pardi R, Schwartz MA, Simons M, Bender JR.

J Exp Med. 2014 Sep 22;211 (10) :1957-68. Epub 2014 Sep 1. PMID: 25180062

23.

PTP1b is a physiologic regulator of vascular endothelial growth factor signaling in endothelial cells.

Lanahan AA, Lech D, Dubrac A, Zhang J, Zhuang ZW, Eichmann A, Simons M.

Circulation. 2014 Sep 9;130 (11) :902-9. Epub 2014 Jun 30. PMID: 24982127

24.

Arterial innervation in development and disease.

Eichmann A, Brunet I.

Sci Transl Med. 2014 Sep 3;6 (252) :252ps9. PMID: 25186174

25.

Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates.

Lee MY, Luciano AK, Ackah E, Rodriguez-Vita J, Bancroft TA, Eichmann A, Simons M, Kyriakides TR, Morales-Ruiz M, Sessa WC.

Proc Natl Acad Sci U S A. 2014 Sep 2;111 (35) :12865-70. Epub 2014 Aug 18. PMID: 25136137

26.

Diversity is in my veins: role of bone morphogenetic protein signaling during venous morphogenesis in zebrafish illustrates the heterogeneity within endothelial cells.

Kim JD, Lee HW, Jin SW.

Arterioscler Thromb Vasc Biol. 2014 Sep;34 (9) :1838-45. Epub 2014 Jul 24. PMID: 25060789

27.

A brief etymology of the collateral circulation.

Faber JE, Chilian WM, Deindl E, van Royen N, Simons M.

Arterioscler Thromb Vasc Biol. 2014 Sep;34 (9) :1854-9. Epub 2014 Jul 10. PMID: 25012127

28.

Receptor tyrosine kinases endocytosis in endothelium: biology and signaling.

Zhang X, Simons M.

Arterioscler Thromb Vasc Biol. 2014 Sep;34 (9) :1831-7. Epub 2014 Jun 12. PMID: 24925972

29.

Plasma cardiotrophin-1 levels are associated with hypertensive heart disease: a meta-analysis.

Song K, Wang S, Huang B, Luciano A, Srivastava R, Mani A.

J Clin Hypertens (Greenwich). 2014 Sep;16 (9) :686-92. Epub 2014 Jul 23. PMID: 25052897

30.

The metabolic syndrome and DYRK1B.

Keramati AR, Fathzadeh M, Mani A.

N Engl J Med. 2014 Aug 21;371 (8) :785-6. PMID: 25140972

31.

Response to letter regarding article, "ten-eleven translocation-2 (TET2) is a master regulator of smooth muscle cell plasticity".

Liu R, Jin Y, Tang W, Qin L, Zhang X, Tellides G, Hwa J, Yu J, Martin KA.

Circulation. 2014 Aug 19;130 (8) :e72. PMID: 25135133

32.

Tension-sensitive actin assembly supports contractility at the epithelial zonula adherens.

Leerberg JM, Gomez GA, Verma S, Moussa EJ, Wu SK, Priya R, Hoffman BD, Grashoff C, Schwartz MA, Yap AS.

Curr Biol. 2014 Aug 4;24 (15) :1689-99. Epub 2014 Jul 24. PMID: 25065757

33.

Induced pluripotent stem cells for regenerative medicine.

Hirschi KK, Li S, Roy K.

Annu Rev Biomed Eng. 2014 Jul 11;16 :277-94. Epub 2014 May 29. PMID: 24905879

34.

The H2.0-like homeobox transcription factor modulates yolk sac vascular remodeling in mouse embryos.

Prahst C, Kasaai B, Moraes F, Jahnsen ED, Larrivee B, Villegas D, Pardanaud L, Pibouin-Fragner L, Zhang F, Zaun HC, Eichmann A, Jones EA.

Arterioscler Thromb Vasc Biol. 2014 Jul;34 (7) :1468-76. Epub 2014 Apr 24. PMID: 24764455

35.

The tumor microenvironment shapes lineage, transcriptional, and functional diversity of infiltrating myeloid cells.

Elpek KG, Cremasco V, Shen H, Harvey CJ, Wucherpfennig KW, Goldstein DR, Monach PA, Turley SJ.

Cancer Immunol Res. 2014 Jul;2 (7) :655-67. Epub 2014 Mar 31. PMID: 24801837

36.

Netrin-1 controls sympathetic arterial innervation.

Brunet I, Gordon E, Han J, Cristofaro B, Broqueres-You D, Liu C, Bouvrée K, Zhang J, del Toro R, Mathivet T, Larrivée B, Jagu J, Pibouin-Fragner L, Pardanaud L, Machado MJ, Kennedy TE, Zhuang Z, Simons M, Levy BI, Tessier-Lavigne M, Grenz A, Eltzschig H, Eichmann A.

J Clin Invest. 2014 Jul;124 (7) :3230-40. Epub 2014 Jun 17. PMID: 24937433

37.

A tale of two models: mouse and zebrafish as complementary models for lymphatic studies.

Kim JD, Jin SW.

Mol Cells. 2014 Jul;37 (7) :503-10. Epub 2014 May 23. PMID: 24854860

38.

Live cell imaging of primary rat neonatal cardiomyocytes following adenoviral and lentiviral transduction using confocal spinning disk microscopy.

Sakurai T, Lanahan A, Woolls MJ, Li N, Tirziu D, Murakami M.

J Vis Exp. 2014 Jun 24; (88) :e51666. Epub 2014 Jun 24. PMID: 24998400

39.

Vasa vasorum in normal and diseased arteries.

Mulligan-Kehoe MJ, Simons M.

Circulation. 2014 Jun 17;129 (24) :2557-66. PMID: 24934463

40.

Development and pathologies of the arterial wall.

Seidelmann SB, Lighthouse JK, Greif DM.

Cell Mol Life Sci. 2014 Jun;71 (11) :1977-99. Epub 2013 Sep 27. PMID: 24071897

41.

Endothelial estrogen receptor isoforms and cardiovascular disease.

Kim KH, Young BD, Bender JR.

Mol Cell Endocrinol. 2014 May 25;389 (1-2) :65-70. Epub 2014 Feb 11. PMID: 24530925

42.

A form of the metabolic syndrome associated with mutations in DYRK1B.

Keramati AR, Fathzadeh M, Go GW, Singh R, Choi M, Faramarzi S, Mane S, Kasaei M, Sarajzadeh-Fard K, Hwa J, Kidd KK, Babaee Bigi MA, Malekzadeh R, Hosseinian A, Babaei M, Lifton RP, Mani A.

N Engl J Med. 2014 May 15;370 (20) :1909-19. PMID: 24827035

43.

Cell biology. Dysfunctional mechanosensing in aneurysms.

Humphrey JD, Milewicz DM, Tellides G, Schwartz MA.

Science. 2014 May 2;344 (6183) :477-9. PMID: 24786066

44.

Ceramide-activated phosphatase mediates fatty acid-induced endothelial VEGF resistance and impaired angiogenesis.

Mehra VC, Jackson E, Zhang XM, Jiang XC, Dobrucki LW, Yu J, Bernatchez P, Sinusas AJ, Shulman GI, Sessa WC, Yarovinsky TO, Bender JR.

Am J Pathol. 2014 May;184 (5) :1562-76. Epub 2014 Mar 5. PMID: 24606881

45.

Aldose reductase-mediated phosphorylation of p53 leads to mitochondrial dysfunction and damage in diabetic platelets.

Tang WH, Stitham J, Jin Y, Liu R, Lee SH, Du J, Atteya G, Gleim S, Spollett G, Martin K, Hwa J.

Circulation. 2014 Apr 15;129 (15) :1598-609. Epub 2014 Jan 28. PMID: 24474649

46.

The docking protein FRS2α is a critical regulator of VEGF receptors signaling.

Chen PY, Qin L, Zhuang ZW, Tellides G, Lax I, Schlessinger J, Simons M.

Proc Natl Acad Sci U S A. 2014 Apr 15;111 (15) :5514-9. Epub 2014 Apr 2. PMID: 24706887

47.

Vascular biology: Brain vessels squeezed to death.

Greif DM, Eichmann A.

Nature. 2014 Apr 3;508 (7494) :50-1. Epub 2014 Mar 26. PMID: 24670635

48.

Advancements in Induced Pluripotent Stem Cell Technology for Cardiac Regenerative Medicine.

Suh CY, Wang Z, Bártulos O, Qyang Y.

J Cardiovasc Pharmacol Ther. 2014 Mar 19;19 (4) :330-339. Epub 2014 Mar 19. PMID: 24651517

49.

Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance.

Cao Z, Ding BS, Guo P, Lee SB, Butler JM, Casey SC, Simons M, Tam W, Felsher DW, Shido K, Rafii A, Scandura JM, Rafii S.

Cancer Cell. 2014 Mar 17;25 (3) :350-65. PMID: 24651014

50.

Recapitulation of developing artery muscularization in pulmonary hypertension.

Sheikh AQ, Lighthouse JK, Greif DM.

Cell Rep. 2014 Mar 13;6 (5) :809-17. Epub 2014 Feb 27. PMID: 24582963

51.

Inflammatory triggers of acute rejection of organ allografts.

Mori DN, Kreisel D, Fullerton JN, Gilroy DW, Goldstein DR.

Immunol Rev. 2014 Mar;258 (1) :132-44. PMID: 24517430

52.

The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue.

Go GW, Srivastava R, Hernandez-Ono A, Gang G, Smith SB, Booth CJ, Ginsberg HN, Mani A.

Cell Metab. 2014 Feb 4;19 (2) :209-20. PMID: 24506864

53.

Essential role of Apelin signaling during lymphatic development in zebrafish.

Kim JD, Kang Y, Kim J, Papangeli I, Kang H, Wu J, Park H, Nadelmann E, Rockson SG, Chun HJ, Jin SW.

Arterioscler Thromb Vasc Biol. 2014 Feb;34 (2) :338-45. Epub 2013 Dec 5. PMID: 24311379

54.

Endothelium as a gatekeeper of fatty acid transport.

Mehrotra D, Wu J, Papangeli I, Chun HJ.

Trends Endocrinol Metab. 2014 Feb;25 (2) :99-106. Epub 2013 Dec 3. PMID: 24315207

55.

Saponin monomer 13 of dwarf lilyturf tuber (DT-13) protects serum withdrawal-induced apoptosis through PI3K/Akt in HUVEC.

Qiu C, Jozsef L, Yu B, Yu J.

Biochem Biophys Res Commun. 2014 Jan 3;443 (1) :74-9. Epub 2013 Nov 19. PMID: 24269237

56.

Bone morphogenetic protein 2 signaling negatively modulates lymphatic development in vertebrate embryos.

Dunworth WP, Cardona-Costa J, Bozkulak EC, Kim JD, Meadows S, Fischer JC, Wang Y, Cleaver O, Qyang Y, Ober EA, Jin SW.

Circ Res. 2014 Jan 3;114 (1) :56-66. Epub 2013 Oct 11. PMID: 24122719

57.

Angiopoietin-2 secretion by endothelial cell exosomes: regulation by the phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric oxide synthase (eNOS) and syndecan-4/syntenin pathways.

Ju R, Zhuang ZW, Zhang J, Lanahan AA, Kyriakides T, Sessa WC, Simons M.

J Biol Chem. 2014 Jan 3;289 (1) :510-9. Epub 2013 Nov 14. PMID: 24235146

58.

Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis.

Ding BS, Cao Z, Lis R, Nolan DJ, Guo P, Simons M, Penfold ME, Shido K, Rabbany SY, Rafii S.

Nature. 2014 Jan 2;505 (7481) :97-102. Epub 2013 Nov 20. PMID: 24256728

59.

Tumor and endothelial cell hybrids participate in glioblastoma vasculature.

El Hallani S, Colin C, El Houfi Y, Idbaih A, Boisselier B, Marie Y, Ravassard P, Labussière M, Mokhtari K, Thomas JL, Delattre JY, Eichmann A, Sanson M.

Biomed Res Int. 2014;2014 :827327. Epub 2014 Apr 24. PMID: 24868550

60.

Silver lining in the dark cloud of aneurysm disease.

Chau KH, Bender JR, Elefteriades JA.

Cardiology. 2014;128 (4) :327-32. Epub 2014 Jun 17. PMID: 24942201

61.

Multimodality imaging approach for serial assessment of regional changes in lower extremity arteriogenesis and tissue perfusion in a porcine model of peripheral arterial disease.

Stacy MR, Yu da Y, Maxfield MW, Jaba IM, Jozwik BP, Zhuang ZW, Lin BA, Hawley CL, Caracciolo CM, Pal P, Tirziu D, Sampath S, Sinusas AJ.

Circ Cardiovasc Imaging. 2014 Jan;7 (1) :92-9. Epub 2013 Oct 29. PMID: 24170237

62.

Editorial: pharmacogenetics and molecular medicine: "so close and yet so far".

Moore JH, Hwa J.

Curr Mol Med. 2014;14 (7) :803-4. PMID: 25109800

63.

Functional cardiomyocytes derived from Isl1 cardiac progenitors via Bmp4 stimulation.

Cagavi E, Bartulos O, Suh CY, Sun B, Yue Z, Jiang Z, Yue L, Qyang Y.

PLoS One. 2014;9 (12) :e110752. Epub 2014 Dec 18. PMID: 25522363

64.

FIH-1, a novel interactor of mindbomb, functions as an essential anti-angiogenic factor during zebrafish vascular development.

So JH, Kim JD, Yoo KW, Kim HT, Jung SH, Choi JH, Lee MS, Jin SW, Kim CH.

PLoS One. 2014;9 (10) :e109517. Epub 2014 Oct 27. PMID: 25347788

65.

Inter-cellular exchange of cellular components via VE-cadherin-dependent trans-endocytosis.

Sakurai T, Woolls MJ, Jin SW, Murakami M, Simons M.

PLoS One. 2014;9 (6) :e90736. Epub 2014 Mar 6. PMID: 24603875

66.

Inverse agonism of SQ 29,548 and Ramatroban on Thromboxane A2 receptor.

Chakraborty R, Bhullar RP, Dakshinamurti S, Hwa J, Chelikani P.

PLoS One. 2014;9 (1) :e85937. Epub 2014 Jan 23. PMID: 24465800

67.

Resveratrol induces vascular smooth muscle cell differentiation through stimulation of SirT1 and AMPK.

Thompson AM, Martin KA, Rzucidlo EM.

PLoS One. 2014;9 (1) :e85495. Epub 2014 Jan 8. PMID: 24416418

68.

Flow-regulated lymphatic vasculature development and signaling.

Wang Y, Simons M.

Vasc Cell. 2014;6 :14. Epub 2014 Jul 9. PMID: 25053993

2013

1.

Development and pathologies of the arterial wall.

Seidelmann SB, Lighthouse JK, Greif DM.

Cell Mol Life Sci. 2014 Jun;71 (11) :1977-99. Epub 2013 Sep 27. PMID: 24071897

2.

Essential role of Apelin signaling during lymphatic development in zebrafish.

Kim JD, Kang Y, Kim J, Papangeli I, Kang H, Wu J, Park H, Nadelmann E, Rockson SG, Chun HJ, Jin SW.

Arterioscler Thromb Vasc Biol. 2014 Feb;34 (2) :338-45. Epub 2013 Dec 5. PMID: 24311379

3.

Endothelium as a gatekeeper of fatty acid transport.

Mehrotra D, Wu J, Papangeli I, Chun HJ.

Trends Endocrinol Metab. 2014 Feb;25 (2) :99-106. Epub 2013 Dec 3. PMID: 24315207

4.

Saponin monomer 13 of dwarf lilyturf tuber (DT-13) protects serum withdrawal-induced apoptosis through PI3K/Akt in HUVEC.

Qiu C, Jozsef L, Yu B, Yu J.

Biochem Biophys Res Commun. 2014 Jan 3;443 (1) :74-9. Epub 2013 Nov 19. PMID: 24269237

5.

Bone morphogenetic protein 2 signaling negatively modulates lymphatic development in vertebrate embryos.

Dunworth WP, Cardona-Costa J, Bozkulak EC, Kim JD, Meadows S, Fischer JC, Wang Y, Cleaver O, Qyang Y, Ober EA, Jin SW.

Circ Res. 2014 Jan 3;114 (1) :56-66. Epub 2013 Oct 11. PMID: 24122719

6.

Angiopoietin-2 secretion by endothelial cell exosomes: regulation by the phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric oxide synthase (eNOS) and syndecan-4/syntenin pathways.

Ju R, Zhuang ZW, Zhang J, Lanahan AA, Kyriakides T, Sessa WC, Simons M.

J Biol Chem. 2014 Jan 3;289 (1) :510-9. Epub 2013 Nov 14. PMID: 24235146

7.

Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis.

Ding BS, Cao Z, Lis R, Nolan DJ, Guo P, Simons M, Penfold ME, Shido K, Rabbany SY, Rafii S.

Nature. 2014 Jan 2;505 (7481) :97-102. Epub 2013 Nov 20. PMID: 24256728

8.

Multimodality imaging approach for serial assessment of regional changes in lower extremity arteriogenesis and tissue perfusion in a porcine model of peripheral arterial disease.

Stacy MR, Yu da Y, Maxfield MW, Jaba IM, Jozwik BP, Zhuang ZW, Lin BA, Hawley CL, Caracciolo CM, Pal P, Tirziu D, Sampath S, Sinusas AJ.

Circ Cardiovasc Imaging. 2014 Jan;7 (1) :92-9. Epub 2013 Oct 29. PMID: 24170237

9.

eNOS-derived nitric oxide regulates endothelial barrier function through VE-cadherin and Rho GTPases.

Di Lorenzo A, Lin MI, Murata T, Landskroner-Eiger S, Schleicher M, Kothiya M, Iwakiri Y, Yu J, Huang PL, Sessa WC.

J Cell Sci. 2013 Dec 15;126 (Pt 24) :5541-52. Epub 2013 Sep 17. PMID: 24046447

10.

Hemogenic endothelial cell specification requires c-Kit, Notch signaling, and p27-mediated cell-cycle control.

Marcelo KL, Sills TM, Coskun S, Vasavada H, Sanglikar S, Goldie LC, Hirschi KK.

Dev Cell. 2013 Dec 9;27 (5) :504-15. PMID: 24331925

11.

Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis.

Nie L, Guo X, Esmailzadeh L, Zhang J, Asadi A, Collinge M, Li X, Kim JD, Woolls M, Jin SW, Dubrac A, Eichmann A, Simons M, Bender JR, Sadeghi MM.

J Clin Invest. 2013 Dec;123 (12) :5082-97. Epub 2013 Nov 1. PMID: 24177422

12.

Age-dependent dysregulation of innate immunity.

Shaw AC, Goldstein DR, Montgomery RR.

Nat Rev Immunol. 2013 Dec;13 (12) :875-87. Epub 2013 Oct 25. PMID: 24157572

13.

Flow-dependent cellular mechanotransduction in atherosclerosis.

Conway DE, Schwartz MA.

J Cell Sci. 2013 Nov 15;126 (Pt 22) :5101-9. Epub 2013 Nov 4. PMID: 24190880

14.

Ten-eleven translocation-2 (TET2) is a master regulator of smooth muscle cell plasticity.

Liu R, Jin Y, Tang WH, Qin L, Zhang X, Tellides G, Hwa J, Yu J, Martin KA.

Circulation. 2013 Oct 29;128 (18) :2047-57. Epub 2013 Sep 27. PMID: 24077167

15.

Endothelial cell-dependent regulation of arteriogenesis.

Moraes F, Paye J, Mac Gabhann F, Zhuang ZW, Zhang J, Lanahan AA, Simons M.

Circ Res. 2013 Oct 12;113 (9) :1076-86. Epub 2013 Jul 29. PMID: 23897694

16.

Inhibition of x-box binding protein 1 reduces tunicamycin-induced apoptosis in aged murine macrophages.

Song Y, Shen H, Du W, Goldstein DR.

Aging Cell. 2013 Oct;12 (5) :794-801. Epub 2013 Jul 7. PMID: 23711292

17.

Integrins in mechanotransduction.

Ross TD, Coon BG, Yun S, Baeyens N, Tanaka K, Ouyang M, Schwartz MA.

Curr Opin Cell Biol. 2013 Oct;25 (5) :613-8. Epub 2013 Jun 21. PMID: 23797029

18.

Need glucose to sprout: local metabolic control of angiogenesis.

Eichmann A, Simons M.

EMBO Mol Med. 2013 Oct;5 (10) :1459-61. Epub 2013 Aug 27. PMID: 23982994

19.

Endothelial signaling and the molecular basis of arteriovenous malformation.

Atri D, Larrivée B, Eichmann A, Simons M.

Cell Mol Life Sci. 2013 Sep 28; Epub 2013 Sep 28. PMID: 24077895

20.

Processes of sterile inflammation.

Shen H, Kreisel D, Goldstein DR.

J Immunol. 2013 Sep 15;191 (6) :2857-63. PMID: 24014880

21.

Rare nonconservative LRP6 mutations are associated with metabolic syndrome.

Singh R, Smith E, Fathzadeh M, Liu W, Go GW, Subrahmanyan L, Faramarzi S, McKenna W, Mani A.

Hum Mutat. 2013 Sep;34 (9) :1221-5. Epub 2013 Jun 18. PMID: 23703864

22.

Syndecan-4 signaling at a glance.

Elfenbein A, Simons M.

J Cell Sci. 2013 Sep 1;126 (Pt 17) :3799-804. Epub 2013 Aug 22. PMID: 23970415

23.

Cell migration: Towards the void.

Dufresne ER, Schwartz MA.

Nat Mater. 2013 Sep;12 (9) :783-4. PMID: 23966050

24.

Physiology. Lymphatics are in my veins.

Simons M, Eichmann A.

Science. 2013 Aug 9;341 (6146) :622-4. PMID: 23929973

25.

Impact of aging on antigen presentation cell function of dendritic cells.

Wong C, Goldstein DR.

Curr Opin Immunol. 2013 Aug;25 (4) :535-41. Epub 2013 Jun 24. PMID: 23806201

26.

Patterns of change in nesiritide use in patients with heart failure: how hospitals react to new information.

Partovian C, Li SX, Xu X, Lin H, Strait KM, Hwa J, Krumholz HM.

JACC Heart Fail. 2013 Aug;1 (4) :318-24. Epub 2013 Aug 5. PMID: 24621935

27.

Bevacizumab: finding its niche in the treatment of heart failure secondary to liver vascular malformations in hereditary hemorrhagic telangiectasia.

Young LH, Henderson KJ, White RI, Garcia-Tsao G.

Hepatology. 2013 Jul;58 (1) :442-5. Epub 2013 May 31. PMID: 23686865

28.

Human thromboxane A2 receptor genetic variants: in silico, in vitro and "in platelet" analysis.

Gleim S, Stitham J, Tang WH, Li H, Douville K, Chelikani P, Rade JJ, Martin KA, Hwa J.

PLoS One. 2013;8 (6) :e67314. Epub 2013 Jun 28. PMID: 23840660

29.

Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development.

Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK, McLean DL, Kim JD, Park H, Jin SW, Hwa J, Quertermous T, Chun HJ.

Circ Res. 2013 Jun 21;113 (1) :22-31. Epub 2013 Apr 19. PMID: 23603510

30.

Matrix metalloproteinase inhibitors based on the 3-mercaptopyrrolidine core.

Jin Y, Roycik MD, Bosco DB, Cao Q, Constantino MH, Schwartz MA, Sang QX.

J Med Chem. 2013 Jun 13;56 (11) :4357-73. Epub 2013 May 16. PMID: 23631440

31.

Fluid shear stress on endothelial cells modulates mechanical tension across VE-cadherin and PECAM-1.

Conway DE, Breckenridge MT, Hinde E, Gratton E, Chen CS, Schwartz MA.

Curr Biol. 2013 Jun 3;23 (11) :1024-30. Epub 2013 May 16. PMID: 23684974

32.

Biased suppression of TP homodimerization and signaling through disruption of a TM GxxxGxxxL helical interaction motif.

Frey AJ, Ibrahim S, Gleim S, Hwa J, Smyth EM.

J Lipid Res. 2013 Jun;54 (6) :1678-90. Epub 2013 Mar 14. PMID: 23493750

33.

Endothelial RAF1/ERK activation regulates arterial morphogenesis.

Deng Y, Larrivée B, Zhuang ZW, Atri D, Moraes F, Prahst C, Eichmann A, Simons M.

Blood. 2013 May 9;121 (19) :3988-96, S1-9. Epub 2013 Mar 25. PMID: 23529931

34.

The syndecan-4/protein kinase Cα pathway mediates prostaglandin E2-induced extracellular regulated kinase (ERK) activation in endothelial cells and angiogenesis in vivo.

Corti F, Finetti F, Ziche M, Simons M.

J Biol Chem. 2013 May 3;288 (18) :12712-21. Epub 2013 Mar 22. PMID: 23525101

35.

Rapamycin inhibits smooth muscle cell proliferation and obstructive arteriopathy attributable to elastin deficiency.

Li W, Li Q, Qin L, Ali R, Qyang Y, Tassabehji M, Pober BR, Sessa WC, Giordano FJ, Tellides G.

Arterioscler Thromb Vasc Biol. 2013 May;33 (5) :1028-35. Epub 2013 Mar 14. PMID: 23493289

36.

Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells.

Thomas JL, Baker K, Han J, Calvo C, Nurmi H, Eichmann AC, Alitalo K.

Cell Mol Life Sci. 2013 May;70 (10) :1779-92. Epub 2013 Mar 12. PMID: 23479133

37.

The power of VEGF (vascular endothelial growth factor) family molecules.

Thomas JL, Eichmann A.

Cell Mol Life Sci. 2013 May;70 (10) :1673-4. Epub 2013 Mar 12. PMID: 23475064

38.

Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome.

Lemaire M, Frémeaux-Bacchi V, Schaefer F, Choi M, Tang WH, Le Quintrec M, Fakhouri F, Taque S, Nobili F, Martinez F, Ji W, Overton JD, Mane SM, Nürnberg G, Altmüller J, Thiele H, Morin D, Deschenes G, Baudouin V, Llanas B, Collard L, Majid MA, Simkova E, Nürnberg P, Rioux-Leclerc N, Moeckel GW, Gubler MC, Hwa J, Loirat C, Lifton RP.

Nat Genet. 2013 May;45 (5) :531-6. Epub 2013 Mar 31. PMID: 23542698

39.

The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis.

Lanahan A, Zhang X, Fantin A, Zhuang Z, Rivera-Molina F, Speichinger K, Prahst C, Zhang J, Wang Y, Davis G, Toomre D, Ruhrberg C, Simons M.

Dev Cell. 2013 Apr 29;25 (2) :156-68. PMID: 23639442

40.

Regulation of endothelial cell differentiation and specification.

Marcelo KL, Goldie LC, Hirschi KK.

Circ Res. 2013 Apr 26;112 (9) :1272-87. PMID: 23620236

41.

Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models.

Cristofaro B, Shi Y, Faria M, Suchting S, Leroyer AS, Trindade A, Duarte A, Zovein AC, Iruela-Arispe ML, Nih LR, Kubis N, Henrion D, Loufrani L, Todiras M, Schleifenbaum J, Gollasch M, Zhuang ZW, Simons M, Eichmann A, le Noble F.

Development. 2013 Apr;140 (8) :1720-9. PMID: 23533173

42.

NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth.

Jaba IM, Zhuang ZW, Li N, Jiang Y, Martin KA, Sinusas AJ, Papademetris X, Simons M, Sessa WC, Young LH, Tirziu D.

J Clin Invest. 2013 Apr;123 (4) :1718-31. PMID: 23454748

43.

A computational approach to detect gap junction plaques and associate them with cells in fluorescent images.

Goldberg JS, Vadakkan TJ, Hirschi KK, Dickinson ME.

J Histochem Cytochem. 2013 Apr;61 (4) :283-93. Epub 2013 Jan 15. PMID: 23324867

44.

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation.

Pluznick JL, Protzko RJ, Gevorgyan H, Peterlin Z, Sipos A, Han J, Brunet I, Wan LX, Rey F, Wang T, Firestein SJ, Yanagisawa M, Gordon JI, Eichmann A, Peti-Peterdi J, Caplan MJ.

Proc Natl Acad Sci U S A. 2013 Mar 12;110 (11) :4410-5. Epub 2013 Feb 11. PMID: 23401498

45.

Endothelial ERK signaling controls lymphatic fate specification.

Deng Y, Atri D, Eichmann A, Simons M.

J Clin Invest. 2013 Mar;123 (3) :1202-15. Epub 2013 Feb 8. PMID: 23391722

46.

Severe obstructive sleep apnea increases mortality in patients with ischemic heart disease and myocardial injury.

Won CH, Chun HJ, Chandra SM, Sarinas PS, Chitkara RK, Heidenreich PA.

Sleep Breath. 2013 Mar;17 (1) :85-91. PMID: 22294346

47.

LRP6 enhances glucose metabolism by promoting TCF7L2-dependent insulin receptor expression and IGF receptor stabilization in humans.

Singh R, De Aguiar RB, Naik S, Mani S, Ostadsharif K, Wencker D, Sotoudeh M, Malekzadeh R, Sherwin RS, Mani A.

Cell Metab. 2013 Feb 5;17 (2) :197-209. PMID: 23395167

48.

Connexin45 regulates endothelial-induced mesenchymal cell differentiation toward a mural cell phenotype.

Fang JS, Dai C, Kurjiaka DT, Burt JM, Hirschi KK.

Arterioscler Thromb Vasc Biol. 2013 Feb;33 (2) :362-8. Epub 2012 Dec 6. PMID: 23220276

49.

Mutant-specific gene expression profiling identifies SRY-related HMG box 11b (SOX11b) as a novel regulator of vascular development in zebrafish.

Schmitt CE, Woolls MJ, Jin SW.

Mol Cells. 2013 Feb;35 (2) :166-72. Epub 2013 Feb 21. PMID: 23456338

50.

Vascular endothelial growth factor signaling regulates the segregation of artery and vein via ERK activity during vascular development.

Kim SH, Schmitt CE, Woolls MJ, Holland MB, Kim JD, Jin SW.

Biochem Biophys Res Commun. 2013 Jan 25;430 (4) :1212-6. Epub 2012 Dec 22. PMID: 23266606

51.

Cell biology. Deconstructing dimensionality.

Schwartz MA, Chen CS.

Science. 2013 Jan 25;339 (6118) :402-4. PMID: 23349278

52.

Ezh2 orchestrates topographic migration and connectivity of mouse precerebellar neurons.

Di Meglio T, Kratochwil CF, Vilain N, Loche A, Vitobello A, Yonehara K, Hrycaj SM, Roska B, Peters AH, Eichmann A, Wellik D, Ducret S, Rijli FM.

Science. 2013 Jan 11;339 (6116) :204-7. PMID: 23307742

53.

Syndecan 4 regulation of PDK1-dependent Akt activation.

Ju R, Simons M.

Cell Signal. 2013 Jan;25 (1) :101-5. Epub 2012 Sep 10. PMID: 22975683

54.

Molecular parallels between neural and vascular development.

Eichmann A, Thomas JL.

Cold Spring Harb Perspect Med. 2013 Jan 1;3 (1) :a006551. Epub 2013 Jan 1. PMID: 23024177

55.

New insights into structural determinants for prostanoid thromboxane A2 receptor- and prostacyclin receptor-G protein coupling.

Chakraborty R, Pydi SP, Gleim S, Bhullar RP, Hwa J, Dakshinamurti S, Chelikani P.

Mol Cell Biol. 2013 Jan;33 (2) :184-93. Epub 2012 Oct 29. PMID: 23109431

56.

N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signalling pathways.

Ouyang M, Lu S, Kim T, Chen CE, Seong J, Leckband DE, Wang F, Reynolds AB, Schwartz MA, Wang Y.

Nat Commun. 2013;4 :1589. PMID: 23481397

57.

An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension.

Kim J, Kang Y, Kojima Y, Lighthouse JK, Hu X, Aldred MA, McLean DL, Park H, Comhair SA, Greif DM, Erzurum SC, Chun HJ.

Nat Med. 2013 Jan;19 (1) :74-82. Epub 2012 Dec 23. PMID: 23263626

2012

1.

Connexin45 regulates endothelial-induced mesenchymal cell differentiation toward a mural cell phenotype.

Fang JS, Dai C, Kurjiaka DT, Burt JM, Hirschi KK.

Arterioscler Thromb Vasc Biol. 2013 Feb;33 (2) :362-8. Epub 2012 Dec 6. PMID: 23220276

2.

Vascular endothelial growth factor signaling regulates the segregation of artery and vein via ERK activity during vascular development.

Kim SH, Schmitt CE, Woolls MJ, Holland MB, Kim JD, Jin SW.

Biochem Biophys Res Commun. 2013 Jan 25;430 (4) :1212-6. Epub 2012 Dec 22. PMID: 23266606

3.

Syndecan 4 regulation of PDK1-dependent Akt activation.

Ju R, Simons M.

Cell Signal. 2013 Jan;25 (1) :101-5. Epub 2012 Sep 10. PMID: 22975683

4.

New insights into structural determinants for prostanoid thromboxane A2 receptor- and prostacyclin receptor-G protein coupling.

Chakraborty R, Pydi SP, Gleim S, Bhullar RP, Hwa J, Dakshinamurti S, Chelikani P.

Mol Cell Biol. 2013 Jan;33 (2) :184-93. Epub 2012 Oct 29. PMID: 23109431

5.

An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension.

Kim J, Kang Y, Kojima Y, Lighthouse JK, Hu X, Aldred MA, McLean DL, Park H, Comhair SA, Greif DM, Erzurum SC, Chun HJ.

Nat Med. 2013 Jan;19 (1) :74-82. Epub 2012 Dec 23. PMID: 23263626

6.

FGF regulates TGF-β signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression.

Chen PY, Qin L, Barnes C, Charisse K, Yi T, Zhang X, Ali R, Medina PP, Yu J, Slack FJ, Anderson DG, Kotelianski V, Wang F, Tellides G, Simons M.

Cell Rep. 2012 Dec 27;2 (6) :1684-96. Epub 2012 Nov 29. PMID: 23200853

7.

Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages.

Camelo S, Raoul W, Lavalette S, Calippe B, Cristofaro B, Levy O, Houssier M, Sulpice E, Jonet L, Klein C, Devevre E, Thuret G, Duarte A, Eichmann A, Leconte L, Guillonneau X, Sennlaub F.

Angiogenesis. 2012 Dec;15 (4) :609-22. Epub 2012 Aug 7. PMID: 22869002

8.

IRF3 contributes to sepsis pathogenesis in the mouse cecal ligation and puncture model.

Walker WE, Bozzi AT, Goldstein DR.

J Leukoc Biol. 2012 Dec;92 (6) :1261-8. Epub 2012 Oct 9. PMID: 23048204

9.

Endothelial nuclear factor-κB-dependent regulation of arteriogenesis and branching.

Tirziu D, Jaba IM, Yu P, Larrivée B, Coon BG, Cristofaro B, Zhuang ZW, Lanahan AA, Schwartz MA, Eichmann A, Simons M.

Circulation. 2012 Nov 27;126 (22) :2589-600. Epub 2012 Oct 22. PMID: 23091063

10.

Apelin/APJ signaling is a critical regulator of statin effects in vascular endothelial cells--brief report.

McLean DL, Kim J, Kang Y, Shi H, Atkins GB, Jain MK, Chun HJ.

Arterioscler Thromb Vasc Biol. 2012 Nov;32 (11) :2640-3. Epub 2012 Sep 20. PMID: 22995518

11.

Modeling supravalvular aortic stenosis syndrome with human induced pluripotent stem cells.

Ge X, Ren Y, Bartulos O, Lee MY, Yue Z, Kim KY, Li W, Amos PJ, Bozkulak EC, Iyer A, Zheng W, Zhao H, Martin KA, Kotton DN, Tellides G, Park IH, Yue L, Qyang Y.

Circulation. 2012 Oct 2;126 (14) :1695-704. Epub 2012 Aug 22. PMID: 22914687

12.

An eicosanoid-centric view of atherothrombotic risk factors.

Gleim S, Stitham J, Tang WH, Martin KA, Hwa J.

Cell Mol Life Sci. 2012 Oct;69 (20) :3361-80. Epub 2012 Apr 11. PMID: 22491820

13.

Profilin phosphorylation as a VEGFR effector in angiogenesis.

Simons M, Schwartz MA.

Nat Cell Biol. 2012 Oct;14 (10) :985-7. PMID: 23033049

14.

Cerulein hyperstimulation decreases AMP-activated protein kinase levels at the site of maximal zymogen activation.

Shugrue CA, Alexandre M, de Villalvilla AD, Kolodecik TR, Young LH, Gorelick FS, Thrower EC.

Am J Physiol Gastrointest Liver Physiol. 2012 Sep 15;303 (6) :G723-32. Epub 2012 Jul 19. PMID: 22821946

15.

Radial construction of an arterial wall.

Greif DM, Kumar M, Lighthouse JK, Hum J, An A, Ding L, Red-Horse K, Espinoza FH, Olson L, Offermanns S, Krasnow MA.

Dev Cell. 2012 Sep 11;23 (3) :482-93. PMID: 22975322

16.

AMP-activated protein kinase regulation and biological actions in the heart.

Zaha VG, Young LH.

Circ Res. 2012 Aug 31;111 (6) :800-14. PMID: 22935535

17.

LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis.

Pi X, Schmitt CE, Xie L, Portbury AL, Wu Y, Lockyer P, Dyer LA, Moser M, Bu G, Flynn EJ 3rd, Jin SW, Patterson C.

Circ Res. 2012 Aug 17;111 (5) :564-74. Epub 2012 Jul 9. PMID: 22777006

18.

Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2.

Kim JD, Kang H, Larrivée B, Lee MY, Mettlen M, Schmid SL, Roman BL, Qyang Y, Eichmann A, Jin SW.

Dev Cell. 2012 Aug 14;23 (2) :441-8. PMID: 22898784

19.

"On-target" cardiac effects of anticancer drugs: lessons from new biology.

Simons M, Eichmann A.

J Am Coll Cardiol. 2012 Aug 14;60 (7) :626-7. Epub 2012 Jun 13. PMID: 22703925

20.

Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation.

Bouvrée K, Brunet I, Del Toro R, Gordon E, Prahst C, Cristofaro B, Mathivet T, Xu Y, Soueid J, Fortuna V, Miura N, Aigrot MS, Maden CH, Ruhrberg C, Thomas JL, Eichmann A.

Circ Res. 2012 Aug 3;111 (4) :437-45. Epub 2012 Jun 21. PMID: 22723296

21.

Molecular imaging of vascular endothelial growth factor receptors in graft arteriosclerosis.

Zhang J, Razavian M, Tavakoli S, Nie L, Tellides G, Backer JM, Backer MV, Bender JR, Sadeghi MM.

Arterioscler Thromb Vasc Biol. 2012 Aug;32 (8) :1849-55. Epub 2012 Jun 21. PMID: 22723442

22.

Regenerating functional heart tissue for myocardial repair.

Alcon A, Cagavi Bozkulak E, Qyang Y.

Cell Mol Life Sci. 2012 Aug;69 (16) :2635-56. Epub 2012 Mar 3. PMID: 22388688

23.

An inside view: VEGF receptor trafficking and signaling.

Simons M.

Physiology (Bethesda). 2012 Aug;27 (4) :213-22. PMID: 22875452

24.

Exploration of the antiplatelet activity profile of betulinic acid on human platelets.

Tzakos AG, Kontogianni VG, Tsoumani M, Kyriakou E, Hwa J, Rodrigues FA, Tselepis AD.

J Agric Food Chem. 2012 Jul 18;60 (28) :6977-83. Epub 2012 Jul 3. PMID: 22720759

25.

Partial characterization of the Sox2+ cell population in an adult murine model of digit amputation.

Agrawal V, Siu BF, Chao H, Hirschi KK, Raborn E, Johnson SA, Tottey S, Hurley KB, Medberry CJ, Badylak SF.

Tissue Eng Part A. 2012 Jul;18 (13-14) :1454-63. Epub 2012 Jun 5. PMID: 22530556

26.

Hemogenic endothelium during development and beyond.

Hirschi KK.

Blood. 2012 May 24;119 (21) :4823-7. Epub 2012 Mar 13. PMID: 22415753

27.

Macrophage β2 integrin-mediated, HuR-dependent stabilization of angiogenic factor-encoding mRNAs in inflammatory angiogenesis.

Zhang J, Modi Y, Yarovinsky T, Yu J, Collinge M, Kyriakides T, Zhu Y, Sessa WC, Pardi R, Bender JR.

Am J Pathol. 2012 Apr;180 (4) :1751-60. Epub 2012 Feb 7. PMID: 22322302

28.

VEGF signaling inside vascular endothelial cells and beyond.

Eichmann A, Simons M.

Curr Opin Cell Biol. 2012 Apr;24 (2) :188-93. Epub 2012 Feb 25. PMID: 22366328

29.

Gender-based divergence of cardiovascular outcomes in asymptomatic patients with type 2 diabetes: results from the DIAD study.

Tandon S, Wackers FJ, Inzucchi SE, Bansal S, Staib LH, Chyun DA, Davey JA, Young LH.

Diab Vasc Dis Res. 2012 Apr;9 (2) :124-30. Epub 2012 Jan 6. PMID: 22228772

30.

ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway.

Larrivée B, Prahst C, Gordon E, del Toro R, Mathivet T, Duarte A, Simons M, Eichmann A.

Dev Cell. 2012 Mar 13;22 (3) :489-500. PMID: 22421041

31.

Low density lipoprotein (LDL) receptor-related protein 6 (LRP6) regulates body fat and glucose homeostasis by modulating nutrient sensing pathways and mitochondrial energy expenditure.

Liu W, Singh R, Choi CS, Lee HY, Keramati AR, Samuel VT, Lifton RP, Shulman GI, Mani A.

J Biol Chem. 2012 Mar 2;287 (10) :7213-23. Epub 2012 Jan 9. PMID: 22232553

32.

Mechanisms of dysfunction in senescent pulmonary endothelium.

Jane-Wit D, Chun HJ.

J Gerontol A Biol Sci Med Sci. 2012 Mar;67 (3) :236-41. Epub 2012 Mar 5. PMID: 22396472

33.

Role of aging on innate responses to viral infections.

Goldstein DR.

J Gerontol A Biol Sci Med Sci. 2012 Mar;67 (3) :242-6. Epub 2011 Oct 31. PMID: 22042722

34.

Evaluation of the use of an induced puripotent stem cell sheet for the construction of tissue-engineered vascular grafts.

Hibino N, Duncan DR, Nalbandian A, Yi T, Qyang Y, Shinoka T, Breuer CK.

J Thorac Cardiovasc Surg. 2012 Mar;143 (3) :696-703. Epub 2012 Jan 12. PMID: 22244569

35.

Low-density lipoprotein receptor (LDLR) family orchestrates cholesterol homeostasis.

Go GW, Mani A.

Yale J Biol Med. 2012 Mar;85 (1) :19-28. Epub 2012 Mar 29. PMID: 22461740

36.

Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels.

Batra N, Burra S, Siller-Jackson AJ, Gu S, Xia X, Weber GF, DeSimone D, Bonewald LF, Lafer EM, Sprague E, Schwartz MA, Jiang JX.

Proc Natl Acad Sci U S A. 2012 Feb 28;109 (9) :3359-64. Epub 2012 Feb 13. PMID: 22331870

37.

Lymphatics thrive on stress: mechanical force in lymphatic development.

Schwartz MA, Simons M.

EMBO J. 2012 Feb 15;31 (4) :781-2. Epub 2012 Feb 15. PMID: 22334045

38.

Vascular smooth muscle cell-derived adiponectin: a paracrine regulator of contractile phenotype.

Ding M, Carrão AC, Wagner RJ, Xie Y, Jin Y, Rzucidlo EM, Yu J, Li W, Tellides G, Hwa J, Aprahamian TR, Martin KA.

J Mol Cell Cardiol. 2012 Feb;52 (2) :474-84. Epub 2011 Sep 17. PMID: 21952104

39.

LRP6 protein regulates low density lipoprotein (LDL) receptor-mediated LDL uptake.

Ye ZJ, Go GW, Singh R, Liu W, Keramati AR, Mani A.

J Biol Chem. 2012 Jan 6;287 (2) :1335-44. Epub 2011 Nov 28. PMID: 22128165

40.

Aging enhances the basal production of IL-6 and CCL2 in vascular smooth muscle cells.

Song Y, Shen H, Schenten D, Shan P, Lee PJ, Goldstein DR.

Arterioscler Thromb Vasc Biol. 2012 Jan;32 (1) :103-9. Epub 2011 Oct 27. PMID: 22034510

41.

Cardiovascular regenerative biology.

Badylak SF, Hirschi KK, Niklason LE.

Cells Tissues Organs. 2012;195 (1-2) :4. Epub 2011 Oct 12. PMID: 22179179

42.

Stem cell-derived vascular endothelial cells and their potential application in regenerative medicine.

Chaudhury H, Raborn E, Goldie LC, Hirschi KK.

Cells Tissues Organs. 2012;195 (1-2) :41-7. Epub 2011 Oct 14. PMID: 22005724

43.

Methods of cell purification: a critical juncture for laboratory research and translational science.

Amos PJ, Cagavi Bozkulak E, Qyang Y.

Cells Tissues Organs. 2012;195 (1-2) :26-40. Epub 2011 Oct 12. PMID: 21996576

44.

Lessons from the endothelial junctional mechanosensory complex.

Conway D, Schwartz MA.

F1000 Biol Rep. 2012;4 :1. Epub 2012 Jan 3. PMID: 22238515

45.

Aldose reductase, oxidative stress, and diabetic mellitus.

Tang WH, Martin KA, Hwa J.

Front Pharmacol. 2012;3 :87. Epub 2012 May 9. PMID: 22582044

46.

Haptoglobin activates innate immunity to enhance acute transplant rejection in mice.

Shen H, Song Y, Colangelo CM, Wu T, Bruce C, Scabia G, Galan A, Maffei M, Goldstein DR.

J Clin Invest. 2012 Jan;122 (1) :383-7. Epub 2011 Dec 12. PMID: 22156194

47.

Studying vascular progenitor cells in a neonatal mouse model.

Kienstra KA, Hirschi KK.

Methods Mol Biol. 2012;904 :235-42. PMID: 22890936

48.

Vascular progenitor cell mobilization.

Kienstra KA, Hirschi KK.

Methods Mol Biol. 2012;904 :155-64. PMID: 22890930

49.

Visualizing vascular networks in zebrafish: an introduction to microangiography.

Schmitt CE, Holland MB, Jin SW.

Methods Mol Biol. 2012;843 :59-67. PMID: 22222521

50.

Fibroblast growth factor signaling potentiates VE-cadherin stability at adherens junctions by regulating SHP2.

Hatanaka K, Lanahan AA, Murakami M, Simons M.

PLoS One. 2012;7 (5) :e37600. Epub 2012 May 22. PMID: 22629427

51.

Endothelium derived nitric oxide synthase negatively regulates the PDGF-survivin pathway during flow-dependent vascular remodeling.

Yu J, Zhang Y, Zhang X, Rudic RD, Bauer PM, Altieri DC, Sessa WC.

PLoS One. 2012;7 (2) :e31495. Epub 2012 Feb 15. PMID: 22355372

52.

Site-directed mutations and the polymorphic variant Ala160Thr in the human thromboxane receptor uncover a structural role for transmembrane helix 4.

Chakraborty R, Pydi SP, Gleim S, Dakshinamurti S, Hwa J, Chelikani P.

PLoS One. 2012;7 (1) :e29996. Epub 2012 Jan 17. PMID: 22272267

53.

Derivation of functional ventricular cardiomyocytes using endogenous promoter sequence from murine embryonic stem cells.

Lee MY, Sun B, Schliffke S, Yue Z, Ye M, Paavola J, Bozkulak EC, Amos PJ, Ren Y, Ju R, Jung YW, Ge X, Yue L, Ehrlich BE, Qyang Y.

Stem Cell Res. 2012 Jan;8 (1) :49-57. Epub 2011 Aug 22. PMID: 22099020

54.

Adiponectin in the heart and vascular system.

Ding M, Rzucidlo EM, Davey JC, Xie Y, Liu R, Jin Y, Stavola L, Martin KA.

Vitam Horm. 2012;90 :289-319. PMID: 23017720

2011

1.

Role of aging on innate responses to viral infections.

Goldstein DR.

J Gerontol A Biol Sci Med Sci. 2012 Mar;67 (3) :242-6. Epub 2011 Oct 31. PMID: 22042722

2.

Vascular smooth muscle cell-derived adiponectin: a paracrine regulator of contractile phenotype.

Ding M, Carrão AC, Wagner RJ, Xie Y, Jin Y, Rzucidlo EM, Yu J, Li W, Tellides G, Hwa J, Aprahamian TR, Martin KA.

J Mol Cell Cardiol. 2012 Feb;52 (2) :474-84. Epub 2011 Sep 17. PMID: 21952104

3.

LRP6 protein regulates low density lipoprotein (LDL) receptor-mediated LDL uptake.

Ye ZJ, Go GW, Singh R, Liu W, Keramati AR, Mani A.

J Biol Chem. 2012 Jan 6;287 (2) :1335-44. Epub 2011 Nov 28. PMID: 22128165

4.

Aging enhances the basal production of IL-6 and CCL2 in vascular smooth muscle cells.

Song Y, Shen H, Schenten D, Shan P, Lee PJ, Goldstein DR.

Arterioscler Thromb Vasc Biol. 2012 Jan;32 (1) :103-9. Epub 2011 Oct 27. PMID: 22034510

5.

Cardiovascular regenerative biology.

Badylak SF, Hirschi KK, Niklason LE.

Cells Tissues Organs. 2012;195 (1-2) :4. Epub 2011 Oct 12. PMID: 22179179

6.

Stem cell-derived vascular endothelial cells and their potential application in regenerative medicine.

Chaudhury H, Raborn E, Goldie LC, Hirschi KK.

Cells Tissues Organs. 2012;195 (1-2) :41-7. Epub 2011 Oct 14. PMID: 22005724

7.

Methods of cell purification: a critical juncture for laboratory research and translational science.

Amos PJ, Cagavi Bozkulak E, Qyang Y.

Cells Tissues Organs. 2012;195 (1-2) :26-40. Epub 2011 Oct 12. PMID: 21996576

8.

Haptoglobin activates innate immunity to enhance acute transplant rejection in mice.

Shen H, Song Y, Colangelo CM, Wu T, Bruce C, Scabia G, Galan A, Maffei M, Goldstein DR.

J Clin Invest. 2012 Jan;122 (1) :383-7. Epub 2011 Dec 12. PMID: 22156194

9.

Derivation of functional ventricular cardiomyocytes using endogenous promoter sequence from murine embryonic stem cells.

Lee MY, Sun B, Schliffke S, Yue Z, Ye M, Paavola J, Bozkulak EC, Amos PJ, Ren Y, Ju R, Jung YW, Ge X, Yue L, Ehrlich BE, Qyang Y.

Stem Cell Res. 2012 Jan;8 (1) :49-57. Epub 2011 Aug 22. PMID: 22099020

10.

High density cultures of embryoid bodies enhanced cardiac differentiation of murine embryonic stem cells.

Lee MY, Cagavi Bozkulak E, Schliffke S, Amos PJ, Ren Y, Ge X, Ehrlich BE, Qyang Y.

Biochem Biophys Res Commun. 2011 Dec 9;416 (1-2) :51-7. Epub 2011 Nov 6. PMID: 22079290

11.

Nanoparticle delivery of mycophenolic acid upregulates PD-L1 on dendritic cells to prolong murine allograft survival.

Shirali AC, Look M, Du W, Kassis E, Stout-Delgado HW, Fahmy TM, Goldstein DR.

Am J Transplant. 2011 Dec;11 (12) :2582-92. Epub 2011 Aug 30. PMID: 21883921

12.

Vascular precursor cells.

Chaudhury H, Goldie LC, Hirschi KK.

Genes Cancer. 2011 Dec;2 (12) :1081-4. PMID: 22866199

13.

Bone Morphogenetic Protein functions as a context-dependent angiogenic cue in vertebrates.

Wiley DM, Jin SW.

Semin Cell Dev Biol. 2011 Dec;22 (9) :1012-8. Epub 2011 Oct 12. PMID: 22008724

14.

Endothelial nitric oxide synthase controls the expression of the angiogenesis inhibitor thrombospondin 2.

MacLauchlan S, Yu J, Parrish M, Asoulin TA, Schleicher M, Krady MM, Zeng J, Huang PL, Sessa WC, Kyriakides TR.

Proc Natl Acad Sci U S A. 2011 Nov 15;108 (46) :E1137-45. Epub 2011 Sep 26. PMID: 21949402

15.

Glucose and collagen regulate human platelet activity through aldose reductase induction of thromboxane.

Tang WH, Stitham J, Gleim S, Di Febbo C, Porreca E, Fava C, Tacconelli S, Capone M, Evangelista V, Levantesi G, Wen L, Martin K, Minuz P, Rade J, Patrignani P, Hwa J.

J Clin Invest. 2011 Nov;121 (11) :4462-76. Epub 2011 Oct 17. PMID: 22005299

16.

Splice isoform estrogen receptors as integral transmembrane proteins.

Kim KH, Toomre D, Bender JR.

Mol Biol Cell. 2011 Nov;22 (22) :4415-23. Epub 2011 Sep 21. PMID: 21937726

17.

Efficacy of a vaccine that links viral epitopes to flagellin in protecting aged mice from influenza viral infection.

Leng J, Stout-Delgado HW, Kavita U, Jacobs A, Tang J, Du W, Tussey L, Goldstein DR.

Vaccine. 2011 Oct 19;29 (45) :8147-55. Epub 2011 Aug 18. PMID: 21854824

18.

An age-specific CD8+ T cell pathway that impairs the effectiveness of strategies to prolong allograft survival.

Du W, Shen H, Galan A, Goldstein DR.

J Immunol. 2011 Oct 1;187 (7) :3631-40. Epub 2011 Aug 26. PMID: 21873523

19.

Challenging the surgical rodent hindlimb ischemia model with the miniinterventional technique.

Zhuang ZW, Shi J, Rhodes JM, Tsapakos MJ, Simons M.

J Vasc Interv Radiol. 2011 Oct;22 (10) :1437-46. Epub 2011 Apr 3. PMID: 21459613

20.

Development and application of a multimodal contrast agent for SPECT/CT hybrid imaging.

Criscione JM, Dobrucki LW, Zhuang ZW, Papademetris X, Simons M, Sinusas AJ, Fahmy TM.

Bioconjug Chem. 2011 Sep 21;22 (9) :1784-92. Epub 2011 Sep 6. PMID: 21851119

21.

VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling.

Tammela T, Zarkada G, Nurmi H, Jakobsson L, Heinolainen K, Tvorogov D, Zheng W, Franco CA, Murtomäki A, Aranda E, Miura N, Ylä-Herttuala S, Fruttiger M, Mäkinen T, Eichmann A, Pollard JW, Gerhardt H, Alitalo K.

Nat Cell Biol. 2011 Sep 11;13 (10) :1202-13. Epub 2011 Sep 11. PMID: 21909098

22.

Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells.

Ren Y, Lee MY, Schliffke S, Paavola J, Amos PJ, Ge X, Ye M, Zhu S, Senyei G, Lum L, Ehrlich BE, Qyang Y.

J Mol Cell Cardiol. 2011 Sep;51 (3) :280-7. Epub 2011 May 4. PMID: 21569778

23.

Effects of integrin-mediated cell adhesion on plasma membrane lipid raft components and signaling.

Norambuena A, Schwartz MA.

Mol Biol Cell. 2011 Sep;22 (18) :3456-64. Epub 2011 Jul 27. PMID: 21795400

24.

The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly.

Tao Y, Neppl RL, Huang ZP, Chen J, Tang RH, Cao R, Zhang Y, Jin SW, Wang DZ.

J Cell Biol. 2011 Aug 22;194 (4) :551-65. PMID: 21859860

25.

Dynamic molecular processes mediate cellular mechanotransduction.

Hoffman BD, Grashoff C, Schwartz MA.

Nature. 2011 Jul 20;475 (7356) :316-23. Epub 2011 Jul 20. PMID: 21776077

26.

FGF-dependent regulation of VEGF receptor 2 expression in mice.

Murakami M, Nguyen LT, Hatanaka K, Schachterle W, Chen PY, Zhuang ZW, Black BL, Simons M.

J Clin Invest. 2011 Jul;121 (7) :2668-78. PMID: 21633168

27.

A small molecule AMPK activator protects the heart against ischemia-reperfusion injury.

Kim AS, Miller EJ, Wright TM, Li J, Qi D, Atsina K, Zaha V, Sakamoto K, Young LH.

J Mol Cell Cardiol. 2011 Jul;51 (1) :24-32. Epub 2011 Mar 29. PMID: 21402077

28.

Light-triggered myosin activation for probing dynamic cellular processes.

Goguen BN, Hoffman BD, Sellers JR, Schwartz MA, Imperiali B.

Angew Chem Int Ed Engl. 2011 Jun 14;50 (25) :5667-70. Epub 2011 May 3. PMID: 21542072

29.

Adiponectin induces vascular smooth muscle cell differentiation via repression of mammalian target of rapamycin complex 1 and FoxO4.

Ding M, Xie Y, Wagner RJ, Jin Y, Carrao AC, Liu LS, Guzman AK, Powell RJ, Hwa J, Rzucidlo EM, Martin KA.

Arterioscler Thromb Vasc Biol. 2011 Jun;31 (6) :1403-10. Epub 2011 Mar 31. PMID: 21454807

30.

Distinct signalling pathways regulate sprouting angiogenesis from the dorsal aorta and the axial vein.

Wiley DM, Kim JD, Hao J, Hong CC, Bautch VL, Jin SW.

Nat Cell Biol. 2011 Jun;13 (6) :686-92. Epub 2011 May 15. PMID: 21572418

31.

AMP-activated protein kinase (AMPK) activation and glycogen synthase kinase-3β (GSK-3β) inhibition induce Ca2+-independent deposition of tight junction components at the plasma membrane.

Zhang L, Jouret F, Rinehart J, Sfakianos J, Mellman I, Lifton RP, Young LH, Caplan MJ.

J Biol Chem. 2011 May 13;286 (19) :16879-90. Epub 2011 Mar 7. PMID: 21383016

32.

Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function.

Albinsson S, Skoura A, Yu J, DiLorenzo A, Fernández-Hernando C, Offermanns S, Miano JM, Sessa WC.

PLoS One. 2011 Apr 22;6 (4) :e18869. Epub 2011 Apr 22. PMID: 21526127

33.

Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesis.

Calvo CF, Fontaine RH, Soueid J, Tammela T, Makinen T, Alfaro-Cervello C, Bonnaud F, Miguez A, Benhaim L, Xu Y, Barallobre MJ, Moutkine I, Lyytikkä J, Tatlisumak T, Pytowski B, Zalc B, Richardson W, Kessaris N, Garcia-Verdugo JM, Alitalo K, Eichmann A, Thomas JL.

Genes Dev. 2011 Apr 15;25 (8) :831-44. PMID: 21498572

34.

Enhancing QM/MM molecular dynamics sampling in explicit environments via an orthogonal-space-random-walk-based strategy.

Min D, Chen M, Zheng L, Jin Y, Schwartz MA, Sang QX, Yang W.

J Phys Chem B. 2011 Apr 14;115 (14) :3924-35. Epub 2011 Mar 21. PMID: 21417256

35.

Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension.

Chandra SM, Razavi H, Kim J, Agrawal R, Kundu RK, de Jesus Perez V, Zamanian RT, Quertermous T, Chun HJ.

Arterioscler Thromb Vasc Biol. 2011 Apr;31 (4) :814-20. Epub 2011 Jan 13. PMID: 21233449

36.

MicroRNA-26a is a novel regulator of vascular smooth muscle cell function.

Leeper NJ, Raiesdana A, Kojima Y, Chun HJ, Azuma J, Maegdefessel L, Kundu RK, Quertermous T, Tsao PS, Spin JM.

J Cell Physiol. 2011 Apr;226 (4) :1035-43. PMID: 20857419

37.

Comprehensive biochemical analysis of rare prostacyclin receptor variants: study of association of signaling with coronary artery obstruction.

Stitham J, Arehart E, Elderon L, Gleim SR, Douville K, Kasza Z, Fetalvero K, MacKenzie T, Robb J, Martin KA, Hwa J.

J Biol Chem. 2011 Mar 4;286 (9) :7060-9. Epub 2010 Dec 28. PMID: 21189259

39.

Inflammation and transplantation tolerance.

Goldstein DR.

Semin Immunopathol. 2011 Mar;33 (2) :111-5. Epub 2011 Feb 18. PMID: 21331502

40.

NSAID use selectively increases the risk of non-fatal myocardial infarction: a systematic review of randomised trials and observational studies.

García Rodríguez LA, González-Pérez A, Bueno H, Hwa J.

PLoS One. 2011 Feb 8;6 (2) :e16780. Epub 2011 Feb 8. PMID: 21347435

41.

Src and caveolin-1 reciprocally regulate metastasis via a common downstream signaling pathway in bladder cancer.

Thomas S, Overdevest JB, Nitz MD, Williams PD, Owens CR, Sanchez-Carbayo M, Frierson HF, Schwartz MA, Theodorescu D.

Cancer Res. 2011 Feb 1;71 (3) :832-41. Epub 2010 Dec 10. PMID: 21148751

42.

Wild-type LRP6 inhibits, whereas atherosclerosis-linked LRP6R611C increases PDGF-dependent vascular smooth muscle cell proliferation.

Keramati AR, Singh R, Lin A, Faramarzi S, Ye ZJ, Mane S, Tellides G, Lifton RP, Mani A.

Proc Natl Acad Sci U S A. 2011 Feb 1;108 (5) :1914-8. Epub 2011 Jan 18. PMID: 21245321

43.

Opsin is a phospholipid flippase.

Menon I, Huber T, Sanyal S, Banerjee S, Barré P, Canis S, Warren JD, Hwa J, Sakmar TP, Menon AK.

Curr Biol. 2011 Jan 25;21 (2) :149-53. Epub 2011 Jan 13. PMID: 21236677

44.

Robo4 maintains vessel integrity and inhibits angiogenesis by interacting with UNC5B.

Koch AW, Mathivet T, Larrivée B, Tong RK, Kowalski J, Pibouin-Fragner L, Bouvrée K, Stawicki S, Nicholes K, Rathore N, Scales SJ, Luis E, del Toro R, Freitas C, Bréant C, Michaud A, Corvol P, Thomas JL, Wu Y, Peale F, Watts RJ, Tessier-Lavigne M, Bagri A, Eichmann A.

Dev Cell. 2011 Jan 18;20 (1) :33-46. PMID: 21238923

45.

Phosphorylation of VE-cadherin controls endothelial phenotypes via p120-catenin coupling and Rac1 activation.

Hatanaka K, Simons M, Murakami M.

Am J Physiol Heart Circ Physiol. 2011 Jan;300 (1) :H162-72. Epub 2010 Oct 29. PMID: 21037229

46.

Five-year outcomes in high-risk participants in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) study: a post hoc analysis.

Bansal S, Wackers FJ, Inzucchi SE, Chyun DA, Davey JA, Staib LH, Young LH.

Diabetes Care. 2011 Jan;34 (1) :204-9. Epub 2010 Oct 7. PMID: 20929989

47.

Prostacyclin: an inflammatory paradox.

Stitham J, Midgett C, Martin KA, Hwa J.

Front Pharmacol. 2011;2 :24. Epub 2011 May 13. PMID: 21687516

48.

[A new risk factor in glaucoma?].

Stan C, Tîrziu D, Lupaşcu S.

Oftalmologia. 2011;55 (1) :74-6. PMID: 21774391

49.

Extraembryonic origin of circulating endothelial cells.

Pardanaud L, Eichmann A.

PLoS One. 2011;6 (10) :e25889. Epub 2011 Oct 14. PMID: 22022461

2010

1.

Comprehensive biochemical analysis of rare prostacyclin receptor variants: study of association of signaling with coronary artery obstruction.

Stitham J, Arehart E, Elderon L, Gleim SR, Douville K, Kasza Z, Fetalvero K, MacKenzie T, Robb J, Martin KA, Hwa J.

J Biol Chem. 2011 Mar 4;286 (9) :7060-9. Epub 2010 Dec 28. PMID: 21189259

2.

Src and caveolin-1 reciprocally regulate metastasis via a common downstream signaling pathway in bladder cancer.

Thomas S, Overdevest JB, Nitz MD, Williams PD, Owens CR, Sanchez-Carbayo M, Frierson HF, Schwartz MA, Theodorescu D.

Cancer Res. 2011 Feb 1;71 (3) :832-41. Epub 2010 Dec 10. PMID: 21148751

3.

Phosphorylation of VE-cadherin controls endothelial phenotypes via p120-catenin coupling and Rac1 activation.

Hatanaka K, Simons M, Murakami M.

Am J Physiol Heart Circ Physiol. 2011 Jan;300 (1) :H162-72. Epub 2010 Oct 29. PMID: 21037229

4.

Five-year outcomes in high-risk participants in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) study: a post hoc analysis.

Bansal S, Wackers FJ, Inzucchi SE, Chyun DA, Davey JA, Staib LH, Young LH.

Diabetes Care. 2011 Jan;34 (1) :204-9. Epub 2010 Oct 7. PMID: 20929989

5.

T cell LFA-1 engagement induces HuR-dependent cytokine mRNA stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 signaling cascade.

Ramgolam VS, DeGregorio SD, Rao GK, Collinge M, Subaran SS, Markovic-Plese S, Pardi R, Bender JR.

PLoS One. 2010 Dec 29;5 (12) :e14450. Epub 2010 Dec 29. PMID: 21206905

6.

Identification and regulation of reticulon 4B (Nogo-B) in renal tubular epithelial cells.

Marin EP, Moeckel G, Al-Lamki R, Bradley J, Yan Q, Wang T, Wright PL, Yu J, Sessa WC.

Am J Pathol. 2010 Dec;177 (6) :2765-73. Epub 2010 Oct 22. PMID: 20971739

7.

Establishment and regulation of the HSC niche: Roles of osteoblastic and vascular compartments.

Coskun S, Hirschi KK.

Birth Defects Res C Embryo Today. 2010 Dec;90 (4) :229-42. PMID: 21181885

8.

Impact of aging on viral infections.

Leng J, Goldstein DR.

Microbes Infect. 2010 Dec;12 (14-15) :1120-4. Epub 2010 Sep 16. PMID: 20849976

9.

Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation.

Wright PL, Yu J, Di YP, Homer RJ, Chupp G, Elias JA, Cohn L, Sessa WC.

J Exp Med. 2010 Nov 22;207 (12) :2595-607. Epub 2010 Oct 25. PMID: 20975041

10.

Identification and functional analysis of endothelial tip cell-enriched genes.

del Toro R, Prahst C, Mathivet T, Siegfried G, Kaminker JS, Larrivee B, Breant C, Duarte A, Takakura N, Fukamizu A, Penninger J, Eichmann A.

Blood. 2010 Nov 11;116 (19) :4025-33. Epub 2010 Aug 12. PMID: 20705756

11.

Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity.

Abbas HA, Maccio DR, Coskun S, Jackson JG, Hazen AL, Sills TM, You MJ, Hirschi KK, Lozano G.

Cell Stem Cell. 2010 Nov 5;7 (5) :606-17. PMID: 21040902

12.

Spatiotemporal organization, regulation, and functions of tractions during neutrophil chemotaxis.

Shin ME, He Y, Li D, Na S, Chowdhury F, Poh YC, Collin O, Su P, de Lanerolle P, Schwartz MA, Wang N, Wang F.

Blood. 2010 Oct 28;116 (17) :3297-310. Epub 2010 Jul 8. PMID: 20616216

13.

The non-syndromic familial thoracic aortic aneurysms and dissections maps to 15q21 locus.

Keramati AR, Sadeghpour A, Farahani MM, Chandok G, Mani A.

BMC Med Genet. 2010 Oct 11;11 :143. Epub 2010 Oct 11. PMID: 20937124

14.

Endothelial cell migration during murine yolk sac vascular remodeling occurs by means of a Rac1 and FAK activation pathway in vivo.

Enciso JM, Konecny CM, Karpen HE, Hirschi KK.

Dev Dyn. 2010 Oct;239 (10) :2570-83. PMID: 20737513

15.

Dominant negative actions of human prostacyclin receptor variant through dimerization: implications for cardiovascular disease.

Ibrahim S, Tetruashvily M, Frey AJ, Wilson SJ, Stitham J, Hwa J, Smyth EM.

Arterioscler Thromb Vasc Biol. 2010 Sep;30 (9) :1802-9. Epub 2010 Jun 3. PMID: 20522800

16.

Cell adhesion: integrating cytoskeletal dynamics and cellular tension.

Parsons JT, Horwitz AR, Schwartz MA.

Nat Rev Mol Cell Biol. 2010 Sep;11 (9) :633-43. PMID: 20729930

17.

Cell communications in the heart.

Tirziu D, Giordano FJ, Simons M.

Circulation. 2010 Aug 31;122 (9) :928-37. PMID: 20805439

18.

VEGF blockade inhibits lymphocyte recruitment and ameliorates immune-mediated vascular remodeling.

Zhang J, Silva T, Yarovinsky T, Manes TD, Tavakoli S, Nie L, Tellides G, Pober JS, Bender JR, Sadeghi MM.

Circ Res. 2010 Aug 6;107 (3) :408-17. Epub 2010 Jun 10. PMID: 20538685

19.

Endothelial-specific overexpression of caveolin-1 accelerates atherosclerosis in apolipoprotein E-deficient mice.

Fernández-Hernando C, Yu J, Dávalos A, Prendergast J, Sessa WC.

Am J Pathol. 2010 Aug;177 (2) :998-1003. Epub 2010 Jun 25. PMID: 20581061

20.

Quiescence and activation of stem and precursor cell populations in the subependymal zone of the mammalian brain are associated with distinct cellular and extracellular matrix signals.

Kazanis I, Lathia JD, Vadakkan TJ, Raborn E, Wan R, Mughal MR, Eckley DM, Sasaki T, Patton B, Mattson MP, Hirschi KK, Dickinson ME, ffrench-Constant C.

J Neurosci. 2010 Jul 21;30 (29) :9771-81. PMID: 20660259

21.

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics.

Grashoff C, Hoffman BD, Brenner MD, Zhou R, Parsons M, Yang MT, McLean MA, Sligar SG, Chen CS, Ha T, Schwartz MA.

Nature. 2010 Jul 8;466 (7303) :263-6. PMID: 20613844

22.

Lovastatin induces VSMC differentiation through inhibition of Rheb and mTOR.

Wagner RJ, Martin KA, Powell RJ, Rzucidlo EM.

Am J Physiol Cell Physiol. 2010 Jul;299 (1) :C119-27. Epub 2010 Apr 7. PMID: 20375271

23.

Upregulation of the apelin-APJ pathway promotes neointima formation in the carotid ligation model in mouse.

Kojima Y, Kundu RK, Cox CM, Leeper NJ, Anderson JA, Chun HJ, Ali ZA, Ashley EA, Krieg PA, Quertermous T.

Cardiovasc Res. 2010 Jul 1;87 (1) :156-65. Epub 2010 Feb 22. PMID: 20176814

24.

25.

VEGF and ephrin-B2: a bloody duo.

Germain S, Eichmann A.

Nat Med. 2010 Jul;16 (7) :752-4. PMID: 20613750

26.

Aging, imbalanced inflammation and viral infection.

Goldstein DR.

Virulence. 2010 Jul-Aug;1 (4) :295-8. PMID: 21178458

27.

Atheroprone hemodynamics regulate fibronectin deposition to create positive feedback that sustains endothelial inflammation.

Feaver RE, Gelfand BD, Wang C, Schwartz MA, Blackman BR.

Circ Res. 2010 Jun 11;106 (11) :1703-11. Epub 2010 Apr 8. PMID: 20378855

28.

Vascular potential of human pluripotent stem cells.

Iacobas I, Vats A, Hirschi KK.

Arterioscler Thromb Vasc Biol. 2010 Jun;30 (6) :1110-7. Epub 2010 May 7. PMID: 20453170

29.

Vascular precursors: origin, regulation and function.

Hirschi KK.

Arterioscler Thromb Vasc Biol. 2010 Jun;30 (6) :1078-9. Epub 2010 May 7. PMID: 20453165

30.

VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis.

Lanahan AA, Hermans K, Claes F, Kerley-Hamilton JS, Zhuang ZW, Giordano FJ, Carmeliet P, Simons M.

Dev Cell. 2010 May 18;18 (5) :713-24. Epub 2010 May 6. PMID: 20434959

31.

Axon guidance molecules in vascular patterning.

Adams RH, Eichmann A.

Cold Spring Harb Perspect Biol. 2010 May;2 (5) :a001875. Epub 2010 Mar 31. PMID: 20452960

32.

Hypoxia-driven angiogenesis: role of tip cells and extracellular matrix scaffolding.

Germain S, Monnot C, Muller L, Eichmann A.

Curr Opin Hematol. 2010 May;17 (3) :245-51. PMID: 20308893

33.

Hemato-vascular origins of endothelial progenitor cells?

Chao H, Hirschi KK.

Microvasc Res. 2010 May;79 (3) :169-73. Epub 2010 Feb 10. PMID: 20149806

34.

A new alternative mechanism in glioblastoma vascularization: tubular vasculogenic mimicry.

El Hallani S, Boisselier B, Peglion F, Rousseau A, Colin C, Idbaih A, Marie Y, Mokhtari K, Thomas JL, Eichmann A, Delattre JY, Maniotis AJ, Sanson M.

Brain. 2010 Apr;133 (Pt 4) :973-82. PMID: 20375132

35.

TLR9 and IRF3 cooperate to induce a systemic inflammatory response in mice injected with liposome:DNA.

Walker WE, Booth CJ, Goldstein DR.

Mol Ther. 2010 Apr;18 (4) :775-84. Epub 2010 Feb 9. PMID: 20145605

36.

Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia.

Lebrin F, Srun S, Raymond K, Martin S, van den Brink S, Freitas C, Bréant C, Mathivet T, Larrivée B, Thomas JL, Arthur HM, Westermann CJ, Disch F, Mager JJ, Snijder RJ, Eichmann A, Mummery CL.

Nat Med. 2010 Apr;16 (4) :420-8. Epub 2010 Apr 4. PMID: 20364125

37.

Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza.

London NR, Zhu W, Bozza FA, Smith MC, Greif DM, Sorensen LK, Chen L, Kaminoh Y, Chan AC, Passi SF, Day CW, Barnard DL, Zimmerman GA, Krasnow MA, Li DY.

Sci Transl Med. 2010 Mar 17;2 (23) :23ra19. PMID: 20375003

38.

Activation of Hedgehog signaling by the environmental toxicant arsenic may contribute to the etiology of arsenic-induced tumors.

Fei DL, Li H, Kozul CD, Black KE, Singh S, Gosse JA, DiRenzo J, Martin KA, Wang B, Hamilton JW, Karagas MR, Robbins DJ.

Cancer Res. 2010 Mar 1;70 (5) :1981-8. Epub 2010 Feb 23. PMID: 20179202

39.

Epimorphic regeneration approach to tissue replacement in adult mammals.

Agrawal V, Johnson SA, Reing J, Zhang L, Tottey S, Wang G, Hirschi KK, Braunhut S, Gudas LJ, Badylak SF.

Proc Natl Acad Sci U S A. 2010 Feb 23;107 (8) :3351-5. Epub 2009 Dec 4. PMID: 19966310

40.

Remembrance of dead cells past: discovering that the extracellular matrix is a cell survival factor.

Schwartz MA.

Mol Biol Cell. 2010 Feb 15;21 (4) :499-500. PMID: 20150528

41.

Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3.

Xu Y, Yuan L, Mak J, Pardanaud L, Caunt M, Kasman I, Larrivée B, Del Toro R, Suchting S, Medvinsky A, Silva J, Yang J, Thomas JL, Koch AW, Alitalo K, Eichmann A, Bagri A.

J Cell Biol. 2010 Jan 11;188 (1) :115-30. PMID: 20065093

42.

The role of quaking in mammalian embryonic development.

Justice MJ, Hirschi KK.

Adv Exp Med Biol. 2010;693 :82-92. PMID: 21189687