Publications

2012

1.

Connexin45 regulates endothelial-induced mesenchymal cell differentiation toward a mural cell phenotype.

Fang JS, Dai C, Kurjiaka DT, Burt JM, Hirschi KK.

Arterioscler Thromb Vasc Biol. 2013 Feb;33 (2) :362-8. Epub 2012 Dec 6. PMID: 23220276

2.

Vascular endothelial growth factor signaling regulates the segregation of artery and vein via ERK activity during vascular development.

Kim SH, Schmitt CE, Woolls MJ, Holland MB, Kim JD, Jin SW.

Biochem Biophys Res Commun. 2013 Jan 25;430 (4) :1212-6. Epub 2012 Dec 22. PMID: 23266606

3.

Syndecan 4 regulation of PDK1-dependent Akt activation.

Ju R, Simons M.

Cell Signal. 2013 Jan;25 (1) :101-5. Epub 2012 Sep 10. PMID: 22975683

4.

An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension.

Kim J, Kang Y, Kojima Y, Lighthouse JK, Hu X, Aldred MA, McLean DL, Park H, Comhair SA, Greif DM, Erzurum SC, Chun HJ.

Nat Med. 2013 Jan;19 (1) :74-82. Epub 2012 Dec 23. PMID: 23263626

5.

FGF regulates TGF-β signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression.

Chen PY, Qin L, Barnes C, Charisse K, Yi T, Zhang X, Ali R, Medina PP, Yu J, Slack FJ, Anderson DG, Kotelianski V, Wang F, Tellides G, Simons M.

Cell Rep. 2012 Dec 27;2 (6) :1684-96. Epub 2012 Nov 29. PMID: 23200853

6.

Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages.

Camelo S, Raoul W, Lavalette S, Calippe B, Cristofaro B, Levy O, Houssier M, Sulpice E, Jonet L, Klein C, Devevre E, Thuret G, Duarte A, Eichmann A, Leconte L, Guillonneau X, Sennlaub F.

Angiogenesis. 2012 Dec;15 (4) :609-22. Epub 2012 Aug 7. PMID: 22869002

7.

IRF3 contributes to sepsis pathogenesis in the mouse cecal ligation and puncture model.

Walker WE, Bozzi AT, Goldstein DR.

J Leukoc Biol. 2012 Dec;92 (6) :1261-8. Epub 2012 Oct 9. PMID: 23048204

8.

Endothelial nuclear factor-κB-dependent regulation of arteriogenesis and branching.

Tirziu D, Jaba IM, Yu P, Larrivée B, Coon BG, Cristofaro B, Zhuang ZW, Lanahan AA, Schwartz MA, Eichmann A, Simons M.

Circulation. 2012 Nov 27;126 (22) :2589-600. Epub 2012 Oct 22. PMID: 23091063

9.

Apelin/APJ signaling is a critical regulator of statin effects in vascular endothelial cells--brief report.

McLean DL, Kim J, Kang Y, Shi H, Atkins GB, Jain MK, Chun HJ.

Arterioscler Thromb Vasc Biol. 2012 Nov;32 (11) :2640-3. Epub 2012 Sep 20. PMID: 22995518

10.

Modeling supravalvular aortic stenosis syndrome with human induced pluripotent stem cells.

Ge X, Ren Y, Bartulos O, Lee MY, Yue Z, Kim KY, Li W, Amos PJ, Bozkulak EC, Iyer A, Zheng W, Zhao H, Martin KA, Kotton DN, Tellides G, Park IH, Yue L, Qyang Y.

Circulation. 2012 Oct 2;126 (14) :1695-704. Epub 2012 Aug 22. PMID: 22914687

11.

An eicosanoid-centric view of atherothrombotic risk factors.

Gleim S, Stitham J, Tang WH, Martin KA, Hwa J.

Cell Mol Life Sci. 2012 Oct;69 (20) :3361-80. Epub 2012 Apr 11. PMID: 22491820

12.

Profilin phosphorylation as a VEGFR effector in angiogenesis.

Simons M, Schwartz MA.

Nat Cell Biol. 2012 Oct;14 (10) :985-7. PMID: 23033049

13.

Cerulein hyperstimulation decreases AMP-activated protein kinase levels at the site of maximal zymogen activation.

Shugrue CA, Alexandre M, de Villalvilla AD, Kolodecik TR, Young LH, Gorelick FS, Thrower EC.

Am J Physiol Gastrointest Liver Physiol. 2012 Sep 15;303 (6) :G723-32. Epub 2012 Jul 19. PMID: 22821946

14.

Radial construction of an arterial wall.

Greif DM, Kumar M, Lighthouse JK, Hum J, An A, Ding L, Red-Horse K, Espinoza FH, Olson L, Offermanns S, Krasnow MA.

Dev Cell. 2012 Sep 11;23 (3) :482-93. PMID: 22975322

15.

AMP-activated protein kinase regulation and biological actions in the heart.

Zaha VG, Young LH.

Circ Res. 2012 Aug 31;111 (6) :800-14. PMID: 22935535

16.

LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis.

Pi X, Schmitt CE, Xie L, Portbury AL, Wu Y, Lockyer P, Dyer LA, Moser M, Bu G, Flynn EJ 3rd, Jin SW, Patterson C.

Circ Res. 2012 Aug 17;111 (5) :564-74. Epub 2012 Jul 9. PMID: 22777006

17.

Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2.

Kim JD, Kang H, Larrivée B, Lee MY, Mettlen M, Schmid SL, Roman BL, Qyang Y, Eichmann A, Jin SW.

Dev Cell. 2012 Aug 14;23 (2) :441-8. PMID: 22898784

18.

"On-target" cardiac effects of anticancer drugs: lessons from new biology.

Simons M, Eichmann A.

J Am Coll Cardiol. 2012 Aug 14;60 (7) :626-7. Epub 2012 Jun 13. PMID: 22703925

19.

Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation.

Bouvrée K, Brunet I, Del Toro R, Gordon E, Prahst C, Cristofaro B, Mathivet T, Xu Y, Soueid J, Fortuna V, Miura N, Aigrot MS, Maden CH, Ruhrberg C, Thomas JL, Eichmann A.

Circ Res. 2012 Aug 3;111 (4) :437-45. Epub 2012 Jun 21. PMID: 22723296

20.

Molecular imaging of vascular endothelial growth factor receptors in graft arteriosclerosis.

Zhang J, Razavian M, Tavakoli S, Nie L, Tellides G, Backer JM, Backer MV, Bender JR, Sadeghi MM.

Arterioscler Thromb Vasc Biol. 2012 Aug;32 (8) :1849-55. Epub 2012 Jun 21. PMID: 22723442

21.

Regenerating functional heart tissue for myocardial repair.

Alcon A, Cagavi Bozkulak E, Qyang Y.

Cell Mol Life Sci. 2012 Aug;69 (16) :2635-56. Epub 2012 Mar 3. PMID: 22388688

22.

An inside view: VEGF receptor trafficking and signaling.

Simons M.

Physiology (Bethesda). 2012 Aug;27 (4) :213-22. PMID: 22875452

23.

Partial characterization of the Sox2+ cell population in an adult murine model of digit amputation.

Agrawal V, Siu BF, Chao H, Hirschi KK, Raborn E, Johnson SA, Tottey S, Hurley KB, Medberry CJ, Badylak SF.

Tissue Eng Part A. 2012 Jul;18 (13-14) :1454-63. Epub 2012 Jun 5. PMID: 22530556

24.

Hemogenic endothelium during development and beyond.

Hirschi KK.

Blood. 2012 May 24;119 (21) :4823-7. Epub 2012 Mar 13. PMID: 22415753

25.

Macrophage β2 integrin-mediated, HuR-dependent stabilization of angiogenic factor-encoding mRNAs in inflammatory angiogenesis.

Zhang J, Modi Y, Yarovinsky T, Yu J, Collinge M, Kyriakides T, Zhu Y, Sessa WC, Pardi R, Bender JR.

Am J Pathol. 2012 Apr;180 (4) :1751-60. Epub 2012 Feb 7. PMID: 22322302

26.

VEGF signaling inside vascular endothelial cells and beyond.

Eichmann A, Simons M.

Curr Opin Cell Biol. 2012 Apr;24 (2) :188-93. Epub 2012 Feb 25. PMID: 22366328

27.

Gender-based divergence of cardiovascular outcomes in asymptomatic patients with type 2 diabetes: results from the DIAD study.

Tandon S, Wackers FJ, Inzucchi SE, Bansal S, Staib LH, Chyun DA, Davey JA, Young LH.

Diab Vasc Dis Res. 2012 Apr;9 (2) :124-30. Epub 2012 Jan 6. PMID: 22228772

28.

ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway.

Larrivée B, Prahst C, Gordon E, del Toro R, Mathivet T, Duarte A, Simons M, Eichmann A.

Dev Cell. 2012 Mar 13;22 (3) :489-500. PMID: 22421041

29.

Mechanisms of dysfunction in senescent pulmonary endothelium.

Jane-Wit D, Chun HJ.

J Gerontol A Biol Sci Med Sci. 2012 Mar;67 (3) :236-41. Epub 2012 Mar 5. PMID: 22396472

30.

Role of aging on innate responses to viral infections.

Goldstein DR.

J Gerontol A Biol Sci Med Sci. 2012 Mar;67 (3) :242-6. Epub 2011 Oct 31. PMID: 22042722

31.

Evaluation of the use of an induced puripotent stem cell sheet for the construction of tissue-engineered vascular grafts.

Hibino N, Duncan DR, Nalbandian A, Yi T, Qyang Y, Shinoka T, Breuer CK.

J Thorac Cardiovasc Surg. 2012 Mar;143 (3) :696-703. Epub 2012 Jan 12. PMID: 22244569

32.

Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels.

Batra N, Burra S, Siller-Jackson AJ, Gu S, Xia X, Weber GF, DeSimone D, Bonewald LF, Lafer EM, Sprague E, Schwartz MA, Jiang JX.

Proc Natl Acad Sci U S A. 2012 Feb 28;109 (9) :3359-64. Epub 2012 Feb 13. PMID: 22331870

33.

Lymphatics thrive on stress: mechanical force in lymphatic development.

Schwartz MA, Simons M.

EMBO J. 2012 Feb 15;31 (4) :781-2. Epub 2012 Feb 15. PMID: 22334045

34.

Vascular smooth muscle cell-derived adiponectin: a paracrine regulator of contractile phenotype.

Ding M, Carrão AC, Wagner RJ, Xie Y, Jin Y, Rzucidlo EM, Yu J, Li W, Tellides G, Hwa J, Aprahamian TR, Martin KA.

J Mol Cell Cardiol. 2012 Feb;52 (2) :474-84. Epub 2011 Sep 17. PMID: 21952104

35.

Haptoglobin activates innate immunity to enhance acute transplant rejection in mice.

Shen H, Song Y, Colangelo CM, Wu T, Bruce C, Scabia G, Galan A, Maffei M, Goldstein DR.

J Clin Invest. 2012 Jan 3;122 (1) :383-7. Epub 2011 Dec 12. PMID: 22156194

36.

Aging enhances the basal production of IL-6 and CCL2 in vascular smooth muscle cells.

Song Y, Shen H, Schenten D, Shan P, Lee PJ, Goldstein DR.

Arterioscler Thromb Vasc Biol. 2012 Jan;32 (1) :103-9. Epub 2011 Oct 27. PMID: 22034510

37.

Cardiovascular regenerative biology.

Badylak SF, Hirschi KK, Niklason LE.

Cells Tissues Organs. 2012;195 (1-2) :4. Epub 2011 Oct 12. PMID: 22179179

38.

Stem cell-derived vascular endothelial cells and their potential application in regenerative medicine.

Chaudhury H, Raborn E, Goldie LC, Hirschi KK.

Cells Tissues Organs. 2012;195 (1-2) :41-7. Epub 2011 Oct 14. PMID: 22005724

39.

Methods of cell purification: a critical juncture for laboratory research and translational science.

Amos PJ, Cagavi Bozkulak E, Qyang Y.

Cells Tissues Organs. 2012;195 (1-2) :26-40. Epub 2011 Oct 12. PMID: 21996576

40.

Lessons from the endothelial junctional mechanosensory complex.

Conway D, Schwartz MA.

F1000 Biol Rep. 2012;4 :1. Epub 2012 Jan 3. PMID: 22238515

41.

Aldose reductase, oxidative stress, and diabetic mellitus.

Tang WH, Martin KA, Hwa J.

Front Pharmacol. 2012;3 :87. Epub 2012 May 9. PMID: 22582044

42.

Studying vascular progenitor cells in a neonatal mouse model.

Kienstra KA, Hirschi KK.

Methods Mol Biol. 2012;904 :235-42. PMID: 22890936

43.

Vascular progenitor cell mobilization.

Kienstra KA, Hirschi KK.

Methods Mol Biol. 2012;904 :155-64. PMID: 22890930

44.

Visualizing vascular networks in zebrafish: an introduction to microangiography.

Schmitt CE, Holland MB, Jin SW.

Methods Mol Biol. 2012;843 :59-67. PMID: 22222521

45.

Fibroblast growth factor signaling potentiates VE-cadherin stability at adherens junctions by regulating SHP2.

Hatanaka K, Lanahan AA, Murakami M, Simons M.

PLoS One. 2012;7 (5) :e37600. Epub 2012 May 22. PMID: 22629427

46.

Endothelium derived nitric oxide synthase negatively regulates the PDGF-survivin pathway during flow-dependent vascular remodeling.

Yu J, Zhang Y, Zhang X, Rudic RD, Bauer PM, Altieri DC, Sessa WC.

PLoS One. 2012;7 (2) :e31495. Epub 2012 Feb 15. PMID: 22355372

47.

Derivation of functional ventricular cardiomyocytes using endogenous promoter sequence from murine embryonic stem cells.

Lee MY, Sun B, Schliffke S, Yue Z, Ye M, Paavola J, Bozkulak EC, Amos PJ, Ren Y, Ju R, Jung YW, Ge X, Yue L, Ehrlich BE, Qyang Y.

Stem Cell Res. 2012 Jan;8 (1) :49-57. Epub 2011 Aug 22. PMID: 22099020

48.

Adiponectin in the heart and vascular system.

Ding M, Rzucidlo EM, Davey JC, Xie Y, Liu R, Jin Y, Stavola L, Martin KA.

Vitam Horm. 2012;90 :289-319. PMID: 23017720

2011

1.

Role of aging on innate responses to viral infections.

Goldstein DR.

J Gerontol A Biol Sci Med Sci. 2012 Mar;67 (3) :242-6. Epub 2011 Oct 31. PMID: 22042722

2.

Vascular smooth muscle cell-derived adiponectin: a paracrine regulator of contractile phenotype.

Ding M, Carrão AC, Wagner RJ, Xie Y, Jin Y, Rzucidlo EM, Yu J, Li W, Tellides G, Hwa J, Aprahamian TR, Martin KA.

J Mol Cell Cardiol. 2012 Feb;52 (2) :474-84. Epub 2011 Sep 17. PMID: 21952104

3.

Haptoglobin activates innate immunity to enhance acute transplant rejection in mice.

Shen H, Song Y, Colangelo CM, Wu T, Bruce C, Scabia G, Galan A, Maffei M, Goldstein DR.

J Clin Invest. 2012 Jan 3;122 (1) :383-7. Epub 2011 Dec 12. PMID: 22156194

4.

Aging enhances the basal production of IL-6 and CCL2 in vascular smooth muscle cells.

Song Y, Shen H, Schenten D, Shan P, Lee PJ, Goldstein DR.

Arterioscler Thromb Vasc Biol. 2012 Jan;32 (1) :103-9. Epub 2011 Oct 27. PMID: 22034510

5.

Cardiovascular regenerative biology.

Badylak SF, Hirschi KK, Niklason LE.

Cells Tissues Organs. 2012;195 (1-2) :4. Epub 2011 Oct 12. PMID: 22179179

6.

Stem cell-derived vascular endothelial cells and their potential application in regenerative medicine.

Chaudhury H, Raborn E, Goldie LC, Hirschi KK.

Cells Tissues Organs. 2012;195 (1-2) :41-7. Epub 2011 Oct 14. PMID: 22005724

7.

Methods of cell purification: a critical juncture for laboratory research and translational science.

Amos PJ, Cagavi Bozkulak E, Qyang Y.

Cells Tissues Organs. 2012;195 (1-2) :26-40. Epub 2011 Oct 12. PMID: 21996576

8.

Derivation of functional ventricular cardiomyocytes using endogenous promoter sequence from murine embryonic stem cells.

Lee MY, Sun B, Schliffke S, Yue Z, Ye M, Paavola J, Bozkulak EC, Amos PJ, Ren Y, Ju R, Jung YW, Ge X, Yue L, Ehrlich BE, Qyang Y.

Stem Cell Res. 2012 Jan;8 (1) :49-57. Epub 2011 Aug 22. PMID: 22099020

9.

High density cultures of embryoid bodies enhanced cardiac differentiation of murine embryonic stem cells.

Lee MY, Cagavi Bozkulak E, Schliffke S, Amos PJ, Ren Y, Ge X, Ehrlich BE, Qyang Y.

Biochem Biophys Res Commun. 2011 Dec 9;416 (1-2) :51-7. Epub 2011 Nov 6. PMID: 22079290

10.

Nanoparticle delivery of mycophenolic acid upregulates PD-L1 on dendritic cells to prolong murine allograft survival.

Shirali AC, Look M, Du W, Kassis E, Stout-Delgado HW, Fahmy TM, Goldstein DR.

Am J Transplant. 2011 Dec;11 (12) :2582-92. Epub 2011 Aug 30. PMID: 21883921

11.

Vascular precursor cells.

Chaudhury H, Goldie LC, Hirschi KK.

Genes Cancer. 2011 Dec;2 (12) :1081-4. PMID: 22866199

12.

Bone Morphogenetic Protein functions as a context-dependent angiogenic cue in vertebrates.

Wiley DM, Jin SW.

Semin Cell Dev Biol. 2011 Dec;22 (9) :1012-8. Epub 2011 Oct 12. PMID: 22008724

13.

Endothelial nitric oxide synthase controls the expression of the angiogenesis inhibitor thrombospondin 2.

MacLauchlan S, Yu J, Parrish M, Asoulin TA, Schleicher M, Krady MM, Zeng J, Huang PL, Sessa WC, Kyriakides TR.

Proc Natl Acad Sci U S A. 2011 Nov 15;108 (46) :E1137-45. Epub 2011 Sep 26. PMID: 21949402

14.

Splice isoform estrogen receptors as integral transmembrane proteins.

Kim KH, Toomre D, Bender JR.

Mol Biol Cell. 2011 Nov;22 (22) :4415-23. Epub 2011 Sep 21. PMID: 21937726

15.

Efficacy of a vaccine that links viral epitopes to flagellin in protecting aged mice from influenza viral infection.

Leng J, Stout-Delgado HW, Kavita U, Jacobs A, Tang J, Du W, Tussey L, Goldstein DR.

Vaccine. 2011 Oct 19;29 (45) :8147-55. Epub 2011 Aug 18. PMID: 21854824

16.

An age-specific CD8+ T cell pathway that impairs the effectiveness of strategies to prolong allograft survival.

Du W, Shen H, Galan A, Goldstein DR.

J Immunol. 2011 Oct 1;187 (7) :3631-40. Epub 2011 Aug 26. PMID: 21873523

17.

Challenging the surgical rodent hindlimb ischemia model with the miniinterventional technique.

Zhuang ZW, Shi J, Rhodes JM, Tsapakos MJ, Simons M.

J Vasc Interv Radiol. 2011 Oct;22 (10) :1437-46. Epub 2011 Apr 3. PMID: 21459613

18.

Development and application of a multimodal contrast agent for SPECT/CT hybrid imaging.

Criscione JM, Dobrucki LW, Zhuang ZW, Papademetris X, Simons M, Sinusas AJ, Fahmy TM.

Bioconjug Chem. 2011 Sep 21;22 (9) :1784-92. Epub 2011 Sep 6. PMID: 21851119

19.

VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling.

Tammela T, Zarkada G, Nurmi H, Jakobsson L, Heinolainen K, Tvorogov D, Zheng W, Franco CA, Murtomäki A, Aranda E, Miura N, Ylä-Herttuala S, Fruttiger M, Mäkinen T, Eichmann A, Pollard JW, Gerhardt H, Alitalo K.

Nat Cell Biol. 2011 Sep 11;13 (10) :1202-13. Epub 2011 Sep 11. PMID: 21909098

20.

Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells.

Ren Y, Lee MY, Schliffke S, Paavola J, Amos PJ, Ge X, Ye M, Zhu S, Senyei G, Lum L, Ehrlich BE, Qyang Y.

J Mol Cell Cardiol. 2011 Sep;51 (3) :280-7. Epub 2011 May 4. PMID: 21569778

21.

Effects of integrin-mediated cell adhesion on plasma membrane lipid raft components and signaling.

Norambuena A, Schwartz MA.

Mol Biol Cell. 2011 Sep;22 (18) :3456-64. Epub 2011 Jul 27. PMID: 21795400

22.

The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly.

Tao Y, Neppl RL, Huang ZP, Chen J, Tang RH, Cao R, Zhang Y, Jin SW, Wang DZ.

J Cell Biol. 2011 Aug 22;194 (4) :551-65. PMID: 21859860

23.

Dynamic molecular processes mediate cellular mechanotransduction.

Hoffman BD, Grashoff C, Schwartz MA.

Nature. 2011 Jul 20;475 (7356) :316-23. Epub 2011 Jul 20. PMID: 21776077

24.

FGF-dependent regulation of VEGF receptor 2 expression in mice.

Murakami M, Nguyen LT, Hatanaka K, Schachterle W, Chen PY, Zhuang ZW, Black BL, Simons M.

J Clin Invest. 2011 Jul;121 (7) :2668-78. PMID: 21633168

25.

A small molecule AMPK activator protects the heart against ischemia-reperfusion injury.

Kim AS, Miller EJ, Wright TM, Li J, Qi D, Atsina K, Zaha V, Sakamoto K, Young LH.

J Mol Cell Cardiol. 2011 Jul;51 (1) :24-32. Epub 2011 Mar 29. PMID: 21402077

26.

Light-triggered myosin activation for probing dynamic cellular processes.

Goguen BN, Hoffman BD, Sellers JR, Schwartz MA, Imperiali B.

Angew Chem Int Ed Engl. 2011 Jun 14;50 (25) :5667-70. Epub 2011 May 3. PMID: 21542072

27.

Adiponectin induces vascular smooth muscle cell differentiation via repression of mammalian target of rapamycin complex 1 and FoxO4.

Ding M, Xie Y, Wagner RJ, Jin Y, Carrao AC, Liu LS, Guzman AK, Powell RJ, Hwa J, Rzucidlo EM, Martin KA.

Arterioscler Thromb Vasc Biol. 2011 Jun;31 (6) :1403-10. Epub 2011 Mar 31. PMID: 21454807

28.

Distinct signalling pathways regulate sprouting angiogenesis from the dorsal aorta and the axial vein.

Wiley DM, Kim JD, Hao J, Hong CC, Bautch VL, Jin SW.

Nat Cell Biol. 2011 Jun;13 (6) :686-92. Epub 2011 May 15. PMID: 21572418

29.

AMP-activated protein kinase (AMPK) activation and glycogen synthase kinase-3β (GSK-3β) inhibition induce Ca2+-independent deposition of tight junction components at the plasma membrane.

Zhang L, Jouret F, Rinehart J, Sfakianos J, Mellman I, Lifton RP, Young LH, Caplan MJ.

J Biol Chem. 2011 May 13;286 (19) :16879-90. Epub 2011 Mar 7. PMID: 21383016

30.

Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function.

Albinsson S, Skoura A, Yu J, DiLorenzo A, Fernández-Hernando C, Offermanns S, Miano JM, Sessa WC.

PLoS One. 2011 Apr 22;6 (4) :e18869. Epub 2011 Apr 22. PMID: 21526127

31.

Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesis.

Calvo CF, Fontaine RH, Soueid J, Tammela T, Makinen T, Alfaro-Cervello C, Bonnaud F, Miguez A, Benhaim L, Xu Y, Barallobre MJ, Moutkine I, Lyytikkä J, Tatlisumak T, Pytowski B, Zalc B, Richardson W, Kessaris N, Garcia-Verdugo JM, Alitalo K, Eichmann A, Thomas JL.

Genes Dev. 2011 Apr 15;25 (8) :831-44. PMID: 21498572

32.

Enhancing QM/MM molecular dynamics sampling in explicit environments via an orthogonal-space-random-walk-based strategy.

Min D, Chen M, Zheng L, Jin Y, Schwartz MA, Sang QX, Yang W.

J Phys Chem B. 2011 Apr 14;115 (14) :3924-35. Epub 2011 Mar 21. PMID: 21417256

33.

Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension.

Chandra SM, Razavi H, Kim J, Agrawal R, Kundu RK, de Jesus Perez V, Zamanian RT, Quertermous T, Chun HJ.

Arterioscler Thromb Vasc Biol. 2011 Apr;31 (4) :814-20. Epub 2011 Jan 13. PMID: 21233449

34.

MicroRNA-26a is a novel regulator of vascular smooth muscle cell function.

Leeper NJ, Raiesdana A, Kojima Y, Chun HJ, Azuma J, Maegdefessel L, Kundu RK, Quertermous T, Tsao PS, Spin JM.

J Cell Physiol. 2011 Apr;226 (4) :1035-43. PMID: 20857419

35.

Comprehensive biochemical analysis of rare prostacyclin receptor variants: study of association of signaling with coronary artery obstruction.

Stitham J, Arehart E, Elderon L, Gleim SR, Douville K, Kasza Z, Fetalvero K, MacKenzie T, Robb J, Martin KA, Hwa J.

J Biol Chem. 2011 Mar 4;286 (9) :7060-9. Epub 2010 Dec 28. PMID: 21189259

37.

Inflammation and transplantation tolerance.

Goldstein DR.

Semin Immunopathol. 2011 Mar;33 (2) :111-5. Epub 2011 Feb 18. PMID: 21331502

38.

Src and caveolin-1 reciprocally regulate metastasis via a common downstream signaling pathway in bladder cancer.

Thomas S, Overdevest JB, Nitz MD, Williams PD, Owens CR, Sanchez-Carbayo M, Frierson HF, Schwartz MA, Theodorescu D.

Cancer Res. 2011 Feb 1;71 (3) :832-41. Epub 2010 Dec 10. PMID: 21148751

39.

Robo4 maintains vessel integrity and inhibits angiogenesis by interacting with UNC5B.

Koch AW, Mathivet T, Larrivée B, Tong RK, Kowalski J, Pibouin-Fragner L, Bouvrée K, Stawicki S, Nicholes K, Rathore N, Scales SJ, Luis E, del Toro R, Freitas C, Bréant C, Michaud A, Corvol P, Thomas JL, Wu Y, Peale F, Watts RJ, Tessier-Lavigne M, Bagri A, Eichmann A.

Dev Cell. 2011 Jan 18;20 (1) :33-46. PMID: 21238923

40.

Phosphorylation of VE-cadherin controls endothelial phenotypes via p120-catenin coupling and Rac1 activation.

Hatanaka K, Simons M, Murakami M.

Am J Physiol Heart Circ Physiol. 2011 Jan;300 (1) :H162-72. Epub 2010 Oct 29. PMID: 21037229

41.

Five-year outcomes in high-risk participants in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) study: a post hoc analysis.

Bansal S, Wackers FJ, Inzucchi SE, Chyun DA, Davey JA, Staib LH, Young LH.

Diabetes Care. 2011 Jan;34 (1) :204-9. Epub 2010 Oct 7. PMID: 20929989

42.

Prostacyclin: an inflammatory paradox.

Stitham J, Midgett C, Martin KA, Hwa J.

Front Pharmacol. 2011;2 :24. Epub 2011 May 13. PMID: 21687516

43.

[A new risk factor in glaucoma?].

Stan C, Tîrziu D, Lupaşcu S.

Oftalmologia. 2011;55 (1) :74-6. PMID: 21774391

44.

Extraembryonic origin of circulating endothelial cells.

Pardanaud L, Eichmann A.

PLoS One. 2011;6 (10) :e25889. Epub 2011 Oct 14. PMID: 22022461

2010

1.

Comprehensive biochemical analysis of rare prostacyclin receptor variants: study of association of signaling with coronary artery obstruction.

Stitham J, Arehart E, Elderon L, Gleim SR, Douville K, Kasza Z, Fetalvero K, MacKenzie T, Robb J, Martin KA, Hwa J.

J Biol Chem. 2011 Mar 4;286 (9) :7060-9. Epub 2010 Dec 28. PMID: 21189259

2.

Src and caveolin-1 reciprocally regulate metastasis via a common downstream signaling pathway in bladder cancer.

Thomas S, Overdevest JB, Nitz MD, Williams PD, Owens CR, Sanchez-Carbayo M, Frierson HF, Schwartz MA, Theodorescu D.

Cancer Res. 2011 Feb 1;71 (3) :832-41. Epub 2010 Dec 10. PMID: 21148751

3.

Phosphorylation of VE-cadherin controls endothelial phenotypes via p120-catenin coupling and Rac1 activation.

Hatanaka K, Simons M, Murakami M.

Am J Physiol Heart Circ Physiol. 2011 Jan;300 (1) :H162-72. Epub 2010 Oct 29. PMID: 21037229

4.

Five-year outcomes in high-risk participants in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) study: a post hoc analysis.

Bansal S, Wackers FJ, Inzucchi SE, Chyun DA, Davey JA, Staib LH, Young LH.

Diabetes Care. 2011 Jan;34 (1) :204-9. Epub 2010 Oct 7. PMID: 20929989

5.

T cell LFA-1 engagement induces HuR-dependent cytokine mRNA stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 signaling cascade.

Ramgolam VS, DeGregorio SD, Rao GK, Collinge M, Subaran SS, Markovic-Plese S, Pardi R, Bender JR.

PLoS One. 2010 Dec 29;5 (12) :e14450. Epub 2010 Dec 29. PMID: 21206905

6.

Identification and regulation of reticulon 4B (Nogo-B) in renal tubular epithelial cells.

Marin EP, Moeckel G, Al-Lamki R, Bradley J, Yan Q, Wang T, Wright PL, Yu J, Sessa WC.

Am J Pathol. 2010 Dec;177 (6) :2765-73. Epub 2010 Oct 22. PMID: 20971739

7.

Establishment and regulation of the HSC niche: Roles of osteoblastic and vascular compartments.

Coskun S, Hirschi KK.

Birth Defects Res C Embryo Today. 2010 Dec;90 (4) :229-42. PMID: 21181885

8.

Impact of aging on viral infections.

Leng J, Goldstein DR.

Microbes Infect. 2010 Dec;12 (14-15) :1120-4. Epub 2010 Sep 16. PMID: 20849976

9.

Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation.

Wright PL, Yu J, Di YP, Homer RJ, Chupp G, Elias JA, Cohn L, Sessa WC.

J Exp Med. 2010 Nov 22;207 (12) :2595-607. Epub 2010 Oct 25. PMID: 20975041

10.

Identification and functional analysis of endothelial tip cell-enriched genes.

del Toro R, Prahst C, Mathivet T, Siegfried G, Kaminker JS, Larrivee B, Breant C, Duarte A, Takakura N, Fukamizu A, Penninger J, Eichmann A.

Blood. 2010 Nov 11;116 (19) :4025-33. Epub 2010 Aug 12. PMID: 20705756

11.

Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity.

Abbas HA, Maccio DR, Coskun S, Jackson JG, Hazen AL, Sills TM, You MJ, Hirschi KK, Lozano G.

Cell Stem Cell. 2010 Nov 5;7 (5) :606-17. PMID: 21040902

12.

Spatiotemporal organization, regulation, and functions of tractions during neutrophil chemotaxis.

Shin ME, He Y, Li D, Na S, Chowdhury F, Poh YC, Collin O, Su P, de Lanerolle P, Schwartz MA, Wang N, Wang F.

Blood. 2010 Oct 28;116 (17) :3297-310. Epub 2010 Jul 8. PMID: 20616216

13.

Endothelial cell migration during murine yolk sac vascular remodeling occurs by means of a Rac1 and FAK activation pathway in vivo.

Enciso JM, Konecny CM, Karpen HE, Hirschi KK.

Dev Dyn. 2010 Oct;239 (10) :2570-83. PMID: 20737513

14.

Cell adhesion: integrating cytoskeletal dynamics and cellular tension.

Parsons JT, Horwitz AR, Schwartz MA.

Nat Rev Mol Cell Biol. 2010 Sep;11 (9) :633-43. PMID: 20729930

15.

Cell communications in the heart.

Tirziu D, Giordano FJ, Simons M.

Circulation. 2010 Aug 31;122 (9) :928-37. PMID: 20805439

16.

VEGF blockade inhibits lymphocyte recruitment and ameliorates immune-mediated vascular remodeling.

Zhang J, Silva T, Yarovinsky T, Manes TD, Tavakoli S, Nie L, Tellides G, Pober JS, Bender JR, Sadeghi MM.

Circ Res. 2010 Aug 6;107 (3) :408-17. Epub 2010 Jun 10. PMID: 20538685

17.

Endothelial-specific overexpression of caveolin-1 accelerates atherosclerosis in apolipoprotein E-deficient mice.

Fernández-Hernando C, Yu J, Dávalos A, Prendergast J, Sessa WC.

Am J Pathol. 2010 Aug;177 (2) :998-1003. Epub 2010 Jun 25. PMID: 20581061

18.

Quiescence and activation of stem and precursor cell populations in the subependymal zone of the mammalian brain are associated with distinct cellular and extracellular matrix signals.

Kazanis I, Lathia JD, Vadakkan TJ, Raborn E, Wan R, Mughal MR, Eckley DM, Sasaki T, Patton B, Mattson MP, Hirschi KK, Dickinson ME, ffrench-Constant C.

J Neurosci. 2010 Jul 21;30 (29) :9771-81. PMID: 20660259

19.

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics.

Grashoff C, Hoffman BD, Brenner MD, Zhou R, Parsons M, Yang MT, McLean MA, Sligar SG, Chen CS, Ha T, Schwartz MA.

Nature. 2010 Jul 8;466 (7303) :263-6. PMID: 20613844

20.

Lovastatin induces VSMC differentiation through inhibition of Rheb and mTOR.

Wagner RJ, Martin KA, Powell RJ, Rzucidlo EM.

Am J Physiol Cell Physiol. 2010 Jul;299 (1) :C119-27. Epub 2010 Apr 7. PMID: 20375271

21.

Upregulation of the apelin-APJ pathway promotes neointima formation in the carotid ligation model in mouse.

Kojima Y, Kundu RK, Cox CM, Leeper NJ, Anderson JA, Chun HJ, Ali ZA, Ashley EA, Krieg PA, Quertermous T.

Cardiovasc Res. 2010 Jul 1;87 (1) :156-65. Epub 2010 Feb 22. PMID: 20176814

22.

23.

VEGF and ephrin-B2: a bloody duo.

Germain S, Eichmann A.

Nat Med. 2010 Jul;16 (7) :752-4. PMID: 20613750

24.

Aging, imbalanced inflammation and viral infection.

Goldstein DR.

Virulence. 2010 Jul-Aug;1 (4) :295-8. PMID: 21178458

25.

Atheroprone hemodynamics regulate fibronectin deposition to create positive feedback that sustains endothelial inflammation.

Feaver RE, Gelfand BD, Wang C, Schwartz MA, Blackman BR.

Circ Res. 2010 Jun 11;106 (11) :1703-11. Epub 2010 Apr 8. PMID: 20378855

26.

Vascular potential of human pluripotent stem cells.

Iacobas I, Vats A, Hirschi KK.

Arterioscler Thromb Vasc Biol. 2010 Jun;30 (6) :1110-7. Epub 2010 May 7. PMID: 20453170

27.

Vascular precursors: origin, regulation and function.

Hirschi KK.

Arterioscler Thromb Vasc Biol. 2010 Jun;30 (6) :1078-9. Epub 2010 May 7. PMID: 20453165

28.

VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis.

Lanahan AA, Hermans K, Claes F, Kerley-Hamilton JS, Zhuang ZW, Giordano FJ, Carmeliet P, Simons M.

Dev Cell. 2010 May 18;18 (5) :713-24. Epub 2010 May 6. PMID: 20434959

29.

Axon guidance molecules in vascular patterning.

Adams RH, Eichmann A.

Cold Spring Harb Perspect Biol. 2010 May;2 (5) :a001875. Epub 2010 Mar 31. PMID: 20452960

30.

Hypoxia-driven angiogenesis: role of tip cells and extracellular matrix scaffolding.

Germain S, Monnot C, Muller L, Eichmann A.

Curr Opin Hematol. 2010 May;17 (3) :245-51. PMID: 20308893

31.

Hemato-vascular origins of endothelial progenitor cells?

Chao H, Hirschi KK.

Microvasc Res. 2010 May;79 (3) :169-73. Epub 2010 Feb 10. PMID: 20149806

32.

A new alternative mechanism in glioblastoma vascularization: tubular vasculogenic mimicry.

El Hallani S, Boisselier B, Peglion F, Rousseau A, Colin C, Idbaih A, Marie Y, Mokhtari K, Thomas JL, Eichmann A, Delattre JY, Maniotis AJ, Sanson M.

Brain. 2010 Apr;133 (Pt 4) :973-82. PMID: 20375132

33.

TLR9 and IRF3 cooperate to induce a systemic inflammatory response in mice injected with liposome:DNA.

Walker WE, Booth CJ, Goldstein DR.

Mol Ther. 2010 Apr;18 (4) :775-84. Epub 2010 Feb 9. PMID: 20145605

34.

Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia.

Lebrin F, Srun S, Raymond K, Martin S, van den Brink S, Freitas C, Bréant C, Mathivet T, Larrivée B, Thomas JL, Arthur HM, Westermann CJ, Disch F, Mager JJ, Snijder RJ, Eichmann A, Mummery CL.

Nat Med. 2010 Apr;16 (4) :420-8. Epub 2010 Apr 4. PMID: 20364125

35.

Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza.

London NR, Zhu W, Bozza FA, Smith MC, Greif DM, Sorensen LK, Chen L, Kaminoh Y, Chan AC, Passi SF, Day CW, Barnard DL, Zimmerman GA, Krasnow MA, Li DY.

Sci Transl Med. 2010 Mar 17;2 (23) :23ra19. PMID: 20375003

36.

Activation of Hedgehog signaling by the environmental toxicant arsenic may contribute to the etiology of arsenic-induced tumors.

Fei DL, Li H, Kozul CD, Black KE, Singh S, Gosse JA, DiRenzo J, Martin KA, Wang B, Hamilton JW, Karagas MR, Robbins DJ.

Cancer Res. 2010 Mar 1;70 (5) :1981-8. Epub 2010 Feb 23. PMID: 20179202

37.

Epimorphic regeneration approach to tissue replacement in adult mammals.

Agrawal V, Johnson SA, Reing J, Zhang L, Tottey S, Wang G, Hirschi KK, Braunhut S, Gudas LJ, Badylak SF.

Proc Natl Acad Sci U S A. 2010 Feb 23;107 (8) :3351-5. Epub 2009 Dec 4. PMID: 19966310

38.

Remembrance of dead cells past: discovering that the extracellular matrix is a cell survival factor.

Schwartz MA.

Mol Biol Cell. 2010 Feb 15;21 (4) :499-500. PMID: 20150528

39.

Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3.

Xu Y, Yuan L, Mak J, Pardanaud L, Caunt M, Kasman I, Larrivée B, Del Toro R, Suchting S, Medvinsky A, Silva J, Yang J, Thomas JL, Koch AW, Alitalo K, Eichmann A, Bagri A.

J Cell Biol. 2010 Jan 11;188 (1) :115-30. PMID: 20065093

40.

The role of quaking in mammalian embryonic development.

Justice MJ, Hirschi KK.

Adv Exp Med Biol. 2010;693 :82-92. PMID: 21189687