Suk-Won Jin

Jin, Suk-Won

Research Interests: Vascular development and angiogenesis; Hemogenic endothelium; BMP signaling

     

Jin Lab


My laboratory is interested in understanding molecular and cellular mechanisms that regulate developmental and pathological angiogenesis, using zebrafish as a model system. Currently our major efforts are directed at analyzing the function of Bone Morphogenetic Protein (BMP) signaling during vascular patterning, investigating interaction between endothelial and hematopoietic lineages during development, and analyzing molecular and cellular defects of vascular specific mutations.

Publications

Kim JD, Lee HW and Jin SW: Diversity is in my veins: role of bone morphogenetic protein signaling during venous morphogenesis in zebrafish illustrates the heterogeneity within endothelial cells. Arterioscler Thromb Vasc Biol. 2014 Sep;34 (9) :1838-45. Epub 2014 Jul 24. PMID: 25060789


Kim JD and Jin SW: A tale of two models: mouse and zebrafish as complementary models for lymphatic studies. Mol Cells. 2014 Jul;37 (7) :503-10. Epub 2014 May 23. PMID: 24854860


Kim JD, Kang Y, Kim J, Papangeli I, Kang H, Wu J, Park H, Nadelmann E, Rockson SG, Chun HJ and Jin SW: Essential role of Apelin signaling during lymphatic development in zebrafish. Arterioscler Thromb Vasc Biol. 2014 Feb;34 (2) :338-45. Epub 2013 Dec 5. PMID: 24311379


Dunworth WP, Cardona-Costa J, Bozkulak EC, Kim JD, Meadows S, Fischer JC, Wang Y, Cleaver O, Qyang Y, Ober EA and Jin SW: Bone morphogenetic protein 2 signaling negatively modulates lymphatic development in vertebrate embryos. Circ Res. 2014 Jan 3;114 (1) :56-66. Epub 2013 Oct 11. PMID: 24122719


Sakurai T, Woolls MJ, Jin SW, Murakami M and Simons M: Inter-cellular exchange of cellular components via VE-cadherin-dependent trans-endocytosis. PLoS One. 2014;9 (6) :e90736. Epub 2014 Mar 6. PMID: 24603875

Nie L, Guo X, Esmailzadeh L, Zhang J, Asadi A, Collinge M, Li X, Kim JD, Woolls M, Jin SW, Dubrac A, Eichmann A, Simons M, Bender JR and Sadeghi MM: Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis. J Clin Invest. 2013 Dec 2;123 (12) :5082-97. Epub 2013 Nov 1. PMID: 24177422


Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK, McLean DL, Kim JD, Park H, Jin SW, Hwa J, Quertermous T and Chun HJ: Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development. Circ Res. 2013 Jun 21;113 (1) :22-31. Epub 2013 Apr 19. PMID: 23603510


Schmitt CE, Woolls MJ and Jin SW: Mutant-specific gene expression profiling identifies SRY-related HMG box 11b (SOX11b) as a novel regulator of vascular development in zebrafish. Mol Cells. 2013 Feb;35 (2) :166-72. Epub 2013 Feb 21. PMID: 23456338


Kim SH, Schmitt CE, Woolls MJ, Holland MB, Kim JD and Jin SW: Vascular endothelial growth factor signaling regulates the segregation of artery and vein via ERK activity during vascular development. Biochem Biophys Res Commun. 2013 Jan 25;430 (4) :1212-6. Epub 2012 Dec 22. PMID: 23266606

Pi X, Schmitt CE, Xie L, Portbury AL, Wu Y, Lockyer P, Dyer LA, Moser M, Bu G, Flynn EJ 3rd, Jin SW and Patterson C: LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis. Circ Res. 2012 Aug 17;111 (5) :564-74. Epub 2012 Jul 9. PMID: 22777006


Kim JD, Kang H, Larrivée B, Lee MY, Mettlen M, Schmid SL, Roman BL, Qyang Y, Eichmann A and Jin SW: Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2. Dev Cell. 2012 Aug 14;23 (2) :441-8. PMID: 22898784


Schmitt CE, Holland MB and Jin SW: Visualizing vascular networks in zebrafish: an introduction to microangiography. Methods Mol Biol. 2012;843 :59-67. PMID: 22222521

Wiley DM and Jin SW: Bone Morphogenetic Protein functions as a context-dependent angiogenic cue in vertebrates. Semin Cell Dev Biol. 2011 Dec;22 (9) :1012-8. Epub 2011 Oct 12. PMID: 22008724


Tao Y, Neppl RL, Huang ZP, Chen J, Tang RH, Cao R, Zhang Y, Jin SW and Wang DZ: The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly. J Cell Biol. 2011 Aug 22;194 (4) :551-65. PMID: 21859860


Wiley DM, Kim JD, Hao J, Hong CC, Bautch VL and Jin SW: Distinct signalling pathways regulate sprouting angiogenesis from the dorsal aorta and the axial vein. Nat Cell Biol. 2011 Jun;13 (6) :686-92. Epub 2011 May 15. PMID: 21572418

Lee CY, Vogeli KM, Kim SH, Chong SW, Jiang YJ, Stainier DY and Jin SW: Notch signaling functions as a cell-fate switch between the endothelial and hematopoietic lineages. Curr Biol. 2009 Oct 13;19 (19) :1616-22. Epub 2009 Sep 10. PMID: 19747827


Jin SW and Patterson C: The opening act: vasculogenesis and the origins of circulation. Arterioscler Thromb Vasc Biol. 2009 May;29 (5) :623-9. Epub 2008 Nov 13. PMID: 19008532

Osborne N, Brand-Arzamendi K, Ober EA, Jin SW, Verkade H, Holtzman NG, Yelon D and Stainier DY: The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish. Curr Biol. 2008 Dec 9;18 (23) :1882-8. PMID: 19062281


Jin SW and Patterson C: Partners in crime: how two Sox proteins cooperate to specify arterial fate. Circ Res. 2008 Jan 4;102 (1) :1-2. PMID: 18174468

Jin SW, Herzog W, Santoro MM, Mitchell TS, Frantsve J, Jungblut B, Beis D, Scott IC, D'Amico LA, Ober EA, Verkade H, Field HA, Chi NC, Wehman AM, Baier H and Stainier DY: A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos. Dev Biol. 2007 Jul 1;307 (1) :29-42. Epub 2007 Apr 5. PMID: 17531218


Scott IC, Masri B, D'Amico LA, Jin SW, Jungblut B, Wehman AM, Baier H, Audigier Y and Stainier DY: The g protein-coupled receptor agtrl1b regulates early development of myocardial progenitors. Dev Cell. 2007 Mar;12 (3) :403-13. PMID: 17336906

Vogeli KM, Jin SW, Martin GR and Stainier DY: A common progenitor for haematopoietic and endothelial lineages in the zebrafish gastrula. Nature. 2006 Sep 21;443 (7109) :337-9. PMID: 16988712

Jin SW, Beis D, Mitchell T, Chen JN and Stainier DY: Cellular and molecular analyses of vascular tube and lumen formation in zebrafish. Development. 2005 Dec;132 (23) :5199-209. Epub 2005 Oct 26. PMID: 16251212


Beis D, Bartman T, Jin SW, Scott IC, D'Amico LA, Ober EA, Verkade H, Frantsve J, Field HA, Wehman A, Baier H, Tallafuss A, Bally-Cuif L, Chen JN, Stainier DY and Jungblut B: Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development. Development. 2005 Sep;132 (18) :4193-204. Epub 2005 Aug 17. PMID: 16107477


Bree RT, McLoughlin S, Jin SW, McMeel OM, Stainier DY, Grealy M and Byrnes L: nanor, a novel zygotic gene, is expressed initially at the midblastula transition in zebrafish. Biochem Biophys Res Commun. 2005 Aug 5;333 (3) :722-8. PMID: 15961062


Qian F, Zhen F, Ong C, Jin SW, Meng Soo H, Stainier DY, Lin S, Peng J and Wen Z: Microarray analysis of zebrafish cloche mutant using amplified cDNA and identification of potential downstream target genes. Dev Dyn. 2005 Jul;233 (3) :1163-72. PMID: 15937927

Cho S, Jin SW, Cohen A and Ellis RE: A phylogeny of caenorhabditis reveals frequent loss of introns during nematode evolution. Genome Res. 2004 Jul;14 (7) :1207-20. PMID: 15231741


Parker LH, Schmidt M, Jin SW, Gray AM, Beis D, Pham T, Frantz G, Palmieri S, Hillan K, Stainier DY, De Sauvage FJ and Ye W: The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation. Nature. 2004 Apr 15;428 (6984) :754-8. PMID: 15085134


Ober EA, Olofsson B, Mäkinen T, Jin SW, Shoji W, Koh GY, Alitalo K and Stainier DY: Vegfc is required for vascular development and endoderm morphogenesis in zebrafish. EMBO Rep. 2004 Jan;5 (1) :78-84. PMID: 14710191