My laboratory has had a longstanding interest in inflammation and immunity, as they relate to vascular physiology and pathology.
We are interested in studying novel endothelial and vascular smooth muscle cell signaling pathways that are either disrupted or activated in the context of pulmonary arterial hypertension (PAH), a rare disease with high mortality (up to 45% at three years after diagnosis).
My laboratory studies vascular and lymphatic development, with particular emphasis on mechanisms that direct patterning and guidance.
The overall theme of Dr. Goldstein’s laboratory is how inflammation impacts different disease states.
My laboratory investigates blood vessel morphogenesis, the maintenance of the adult blood vessel and diseases of the vasculature.
A primary interest of our laboratory is to understand, at the cellular and molecular level, the events leading to blood vessel formation.
The goals of the Hwa laboratory are to decipher the roles played by the prostacyclin and thromboxane receptors (both G-protein coupled receptors) in the development of atherothrombosis.
My laboratory’s major focus is the identification of genetic causes of major cardiovascular disorders and the elucidation of their pathophysiology.
Our studies are aimed at understanding the molecular mechanisms that regulate vascular smooth muscle cell (VSMC) phenotype.
My laboratory seeks to understand the basic biology of a novel population of cardiovascular progenitor cells (CPC) derived from heart tissues and embryonic stem (ES) and induced pluripotent stem (iPS) cells.
The ultimate goal of research in our Cardiovascular Molecular Imaging Laboratory is to develop novel imaging approaches to detect the molecular pathobiology of the vessel wall in vivo.
The main research topics in my laboratory are integrin signaling and mechanotransduction in vascular biology, with emphasis on topics that are relevant to human disease.
The major areas of research in my lab include the regulation of arterial development and branching morphogenesis, the regulation of vascular maintenance, Syndecan-4 signaling, and endothelial signaling and metabolism.
My laboratory is interested in bi-directional crosstalk between vascular endothelium and cardiomyocytes that regulates cardiac size and function.
Key areas of our research are the molecular & cellular mechanisms regulating heart (metabolism in cv disease), autocrine-paracrine pathways (modulating cardiac cell signaling and function), and metabolic signaling pathways in atrial fibrillation.