Anne Eichmann

Bio Profile

Anne Eichmann, PhD

Ensign Professor of Medicine (Cardiology) and Professor of Cellular And Molecular Physiology

Research Interests

Blood Vessels; Cardiology; Central Nervous System; Endothelium, Vascular; Physiology

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Eichmann Lab


My laboratory studies vascular and lymphatic development, with particular emphasis on mechanisms that direct patterning and guidance. Specialized endothelial cells (EC) called tip cells located at the extremities of growing capillary sprouts mediate guided vascular patterning. Tip cells exhibit characteristic features, including extension of filopodia that explore the tip cell environment, lack of a lumen and a slow proliferation rate. EC behind tip cells, termed stalk cells form the capillary lumen and proliferate.

Publications

Sun H, Zhu Y, Pan H, Chen X, Balestrini JL, Lam TT, Kanyo JE, Eichmann A, Gulati M, Fares WH, Bai H, Feghali-Bostwick CA, Gan Y, Peng X, Moore MW, White ES, Sava P, Gonzalez AL, Cheng Y, Niklason LE, Herzog EL: Netrin-1 Regulates Fibrocyte Accumulation in the Decellularized Fibrotic Sclerodermatous Lung Microenvironment and in Bleomycin-Induced Pulmonary Fibrosis. Arthritis Rheumatol. 2016 May. PMID: 26749424

Li N, Hwangbo C, Jaba IM, Zhang J, Papangeli I, Han J, Mikush N, Larrivée B, Eichmann A, Chun HJ, Young LH, Tirziu D: miR-182 Modulates Myocardial Hypertrophic Response Induced by Angiogenesis in Heart. Sci Rep. 2016 Feb 18; 2016 Feb 18. PMID: 26888314

Dubrac A, Genet G, Ola R, Zhang F, Pibouin-Fragner L, Han J, Zhang J, Thomas JL, Chedotal A, Schwartz MA, Eichmann A: Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neovascularization. Circulation. 2016 Jan 26; 2015 Dec 9. PMID: 26659946

Labussière M, Cheneau C, Prahst C, Gállego Pérez-Larraya J, Farina P, Lombardi G, Mokhtari K, Rahimian A, Delattre JY, Eichmann A, Sanson M: Angiopoietin-2 May Be Involved in the Resistance to Bevacizumab in Recurrent Glioblastoma. Cancer Invest. 2016; 2016 Jan 6. PMID: 26735326

Minocha S, Valloton D, Brunet I, Eichmann A, Hornung JP, Lebrand C: NG2 glia are required for vessel network formation during embryonic development. Elife. 2015 Dec 10; 2015 Dec 10. PMID: 26651999

Fortuna V, Pardanaud L, Brunet I, Ola R, Ristori E, Santoro MM, Nicoli S, Eichmann A: Vascular Mural Cells Promote Noradrenergic Differentiation of Embryonic Sympathetic Neurons. Cell Rep. 2015 Jun 23; 2015 Jun 11. PMID: 26074079

Aspalter IM, Gordon E, Dubrac A, Ragab A, Narloch J, Vizán P, Geudens I, Collins RT, Franco CA, Abrahams CL, Thurston G, Fruttiger M, Rosewell I, Eichmann A, Gerhardt H: Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch. Nat Commun. 2015 Jun 17; 2015 Jun 17. PMID: 26081042

Simons M, Alitalo K, Annex BH, Augustin HG, Beam C, Berk BC, Byzova T, Carmeliet P, Chilian W, Cooke JP, Davis GE, Eichmann A, Iruela-Arispe ML, Keshet E, Sinusas AJ, Ruhrberg C, Woo YJ, Dimmeler S, American Heart Association Council on Basic Cardiovascular Sciences and Council on Cardiovascular Surgery and Anesthesia: State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization: A Scientific Statement From the American Heart Association. Circ Res. 2015 May 22; 2015 Apr 30. PMID: 25931450

Simons M, Eichmann A: Molecular controls of arterial morphogenesis. Circ Res. 2015 May 8. PMID: 25953926

Rama N, Dubrac A, Mathivet T, Ní Chárthaigh RA, Genet G, Cristofaro B, Pibouin-Fragner L, Ma L, Eichmann A, Chédotal A: Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization. Nat Med. 2015 May; 2015 Apr 20. PMID: 25894826

Han J, Calvo CF, Kang TH, Baker KL, Park JH, Parras C, Levittas M, Birba U, Pibouin-Fragner L, Fragner P, Bilguvar K, Duman RS, Nurmi H, Alitalo K, Eichmann AC, Thomas JL: Vascular endothelial growth factor receptor 3 controls neural stem cell activation in mice and humans. Cell Rep. 2015 Feb 24; 2015 Feb 19. PMID: 25704818

Baeyens N, Nicoli S, Coon BG, Ross TD, Van den Dries K, Han J, Lauridsen HM, Mejean CO, Eichmann A, Thomas JL, Humphrey JD, Schwartz MA: Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point. Elife. 2015 Feb 2; 2015 Feb 2. PMID: 25643397

Lanahan AA, Lech D, Dubrac A, Zhang J, Zhuang ZW, Eichmann A, Simons M: PTP1b is a physiologic regulator of vascular endothelial growth factor signaling in endothelial cells. Circulation. 2014 Sep 9; 2014 Jun 30. PMID: 24982127

Eichmann A, Brunet I: Arterial innervation in development and disease. Sci Transl Med. 2014 Sep 3. PMID: 25186174

Lee MY, Luciano AK, Ackah E, Rodriguez-Vita J, Bancroft TA, Eichmann A, Simons M, Kyriakides TR, Morales-Ruiz M, Sessa WC: Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates. Proc Natl Acad Sci U S A. 2014 Sep 2; 2014 Aug 18. PMID: 25136137

Prahst C, Kasaai B, Moraes F, Jahnsen ED, Larrivee B, Villegas D, Pardanaud L, Pibouin-Fragner L, Zhang F, Zaun HC, Eichmann A, Jones EA: The H2.0-like homeobox transcription factor modulates yolk sac vascular remodeling in mouse embryos. Arterioscler Thromb Vasc Biol. 2014 Jul; 2014 Apr 24. PMID: 24764455

Brunet I, Gordon E, Han J, Cristofaro B, Broqueres-You D, Liu C, Bouvrée K, Zhang J, del Toro R, Mathivet T, Larrivée B, Jagu J, Pibouin-Fragner L, Pardanaud L, Machado MJ, Kennedy TE, Zhuang Z, Simons M, Levy BI, Tessier-Lavigne M, Grenz A, Eltzschig H, Eichmann A: Netrin-1 controls sympathetic arterial innervation. J Clin Invest. 2014 Jul; 2014 Jun 17. PMID: 24937433

Greif DM, Eichmann A: Vascular biology: Brain vessels squeezed to death. Nature. 2014 Apr 3; 2014 Mar 26. PMID: 24670635

El Hallani S, Colin C, El Houfi Y, Idbaih A, Boisselier B, Marie Y, Ravassard P, Labussière M, Mokhtari K, Thomas JL, Delattre JY, Eichmann A, Sanson M: Tumor and endothelial cell hybrids participate in glioblastoma vasculature. Biomed Res Int. 2014; 2014 Apr 24. PMID: 24868550

Nie L, Guo X, Esmailzadeh L, Zhang J, Asadi A, Collinge M, Li X, Kim JD, Woolls M, Jin SW, Dubrac A, Eichmann A, Simons M, Bender JR, Sadeghi MM: Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis. J Clin Invest. 2013 Dec; 2013 Nov 1. PMID: 24177422

Eichmann A, Simons M: Need glucose to sprout: local metabolic control of angiogenesis. EMBO Mol Med. 2013 Oct; 2013 Aug 27. PMID: 23982994

Atri D, Larrivée B, Eichmann A, Simons M: Endothelial signaling and the molecular basis of arteriovenous malformation. Cell Mol Life Sci. 2013 Sep 28; 2013 Sep 28. PMID: 24077895

Simons M, Eichmann A: Physiology. Lymphatics are in my veins. Science. 2013 Aug 9. PMID: 23929973

Deng Y, Larrivée B, Zhuang ZW, Atri D, Moraes F, Prahst C, Eichmann A, Simons M: Endothelial RAF1/ERK activation regulates arterial morphogenesis. Blood. 2013 May 9; 2013 Mar 25. PMID: 23529931

Thomas JL, Baker K, Han J, Calvo C, Nurmi H, Eichmann AC, Alitalo K: Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells. Cell Mol Life Sci. 2013 May; 2013 Mar 12. PMID: 23479133

Thomas JL, Eichmann A: The power of VEGF (vascular endothelial growth factor) family molecules. Cell Mol Life Sci. 2013 May; 2013 Mar 12. PMID: 23475064

Cristofaro B, Shi Y, Faria M, Suchting S, Leroyer AS, Trindade A, Duarte A, Zovein AC, Iruela-Arispe ML, Nih LR, Kubis N, Henrion D, Loufrani L, Todiras M, Schleifenbaum J, Gollasch M, Zhuang ZW, Simons M, Eichmann A, le Noble F: Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models. Development. 2013 Apr. PMID: 23533173

Pluznick JL, Protzko RJ, Gevorgyan H, Peterlin Z, Sipos A, Han J, Brunet I, Wan LX, Rey F, Wang T, Firestein SJ, Yanagisawa M, Gordon JI, Eichmann A, Peti-Peterdi J, Caplan MJ: Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation. Proc Natl Acad Sci U S A. 2013 Mar 12; 2013 Feb 11. PMID: 23401498

Deng Y, Atri D, Eichmann A, Simons M: Endothelial ERK signaling controls lymphatic fate specification. J Clin Invest. 2013 Mar; 2013 Feb 8. PMID: 23391722

Di Meglio T, Kratochwil CF, Vilain N, Loche A, Vitobello A, Yonehara K, Hrycaj SM, Roska B, Peters AH, Eichmann A, Wellik D, Ducret S, Rijli FM: Ezh2 orchestrates topographic migration and connectivity of mouse precerebellar neurons. Science. 2013 Jan 11. PMID: 23307742

Eichmann A, Thomas JL: Molecular parallels between neural and vascular development. Cold Spring Harb Perspect Med. 2013 Jan 1; 2013 Jan 1. PMID: 23024177

Camelo S, Raoul W, Lavalette S, Calippe B, Cristofaro B, Levy O, Houssier M, Sulpice E, Jonet L, Klein C, Devevre E, Thuret G, Duarte A, Eichmann A, Leconte L, Guillonneau X, Sennlaub F: Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages. Angiogenesis. 2012 Dec; 2012 Aug 7. PMID: 22869002

Tirziu D, Jaba IM, Yu P, Larrivée B, Coon BG, Cristofaro B, Zhuang ZW, Lanahan AA, Schwartz MA, Eichmann A, Simons M: Endothelial nuclear factor-κB-dependent regulation of arteriogenesis and branching. Circulation. 2012 Nov 27; 2012 Oct 22. PMID: 23091063

Kim JD, Kang H, Larrivée B, Lee MY, Mettlen M, Schmid SL, Roman BL, Qyang Y, Eichmann A, Jin SW: Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2. Dev Cell. 2012 Aug 14. PMID: 22898784

Simons M, Eichmann A: "On-target" cardiac effects of anticancer drugs: lessons from new biology. J Am Coll Cardiol. 2012 Aug 14; 2012 Jun 13. PMID: 22703925

Bouvrée K, Brunet I, Del Toro R, Gordon E, Prahst C, Cristofaro B, Mathivet T, Xu Y, Soueid J, Fortuna V, Miura N, Aigrot MS, Maden CH, Ruhrberg C, Thomas JL, Eichmann A: Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation. Circ Res. 2012 Aug 3; 2012 Jun 21. PMID: 22723296

Eichmann A, Simons M: VEGF signaling inside vascular endothelial cells and beyond. Curr Opin Cell Biol. 2012 Apr; 2012 Feb 25. PMID: 22366328

Larrivée B, Prahst C, Gordon E, del Toro R, Mathivet T, Duarte A, Simons M, Eichmann A: ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway. Dev Cell. 2012 Mar 13. PMID: 22421041

Tammela T, Zarkada G, Nurmi H, Jakobsson L, Heinolainen K, Tvorogov D, Zheng W, Franco CA, Murtomäki A, Aranda E, Miura N, Ylä-Herttuala S, Fruttiger M, Mäkinen T, Eichmann A, Pollard JW, Gerhardt H, Alitalo K: VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling. Nat Cell Biol. 2011 Sep 11; 2011 Sep 11. PMID: 21909098

Calvo CF, Fontaine RH, Soueid J, Tammela T, Makinen T, Alfaro-Cervello C, Bonnaud F, Miguez A, Benhaim L, Xu Y, Barallobre MJ, Moutkine I, Lyytikkä J, Tatlisumak T, Pytowski B, Zalc B, Richardson W, Kessaris N, Garcia-Verdugo JM, Alitalo K, Eichmann A, Thomas JL: Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesis. Genes Dev. 2011 Apr 15. PMID: 21498572

Koch AW, Mathivet T, Larrivée B, Tong RK, Kowalski J, Pibouin-Fragner L, Bouvrée K, Stawicki S, Nicholes K, Rathore N, Scales SJ, Luis E, del Toro R, Freitas C, Bréant C, Michaud A, Corvol P, Thomas JL, Wu Y, Peale F, Watts RJ, Tessier-Lavigne M, Bagri A, Eichmann A: Robo4 maintains vessel integrity and inhibits angiogenesis by interacting with UNC5B. Dev Cell. 2011 Jan 18. PMID: 21238923

Pardanaud L, Eichmann A: Extraembryonic origin of circulating endothelial cells. PLoS One. 2011; 2011 Oct 14. PMID: 22022461

del Toro R, Prahst C, Mathivet T, Siegfried G, Kaminker JS, Larrivee B, Breant C, Duarte A, Takakura N, Fukamizu A, Penninger J, Eichmann A: Identification and functional analysis of endothelial tip cell-enriched genes. Blood. 2010 Nov 11; 2010 Aug 12. PMID: 20705756

Germain S, Eichmann A: VEGF and ephrin-B2: a bloody duo. Nat Med. 2010 Jul. PMID: 20613750

Adams RH, Eichmann A: Axon guidance molecules in vascular patterning. Cold Spring Harb Perspect Biol. 2010 May; 2010 Mar 31. PMID: 20452960

Germain S, Monnot C, Muller L, Eichmann A: Hypoxia-driven angiogenesis: role of tip cells and extracellular matrix scaffolding. Curr Opin Hematol. 2010 May. PMID: 20308893

El Hallani S, Boisselier B, Peglion F, Rousseau A, Colin C, Idbaih A, Marie Y, Mokhtari K, Thomas JL, Eichmann A, Delattre JY, Maniotis AJ, Sanson M: A new alternative mechanism in glioblastoma vascularization: tubular vasculogenic mimicry. Brain. 2010 Apr. PMID: 20375132

Lebrin F, Srun S, Raymond K, Martin S, van den Brink S, Freitas C, Bréant C, Mathivet T, Larrivée B, Thomas JL, Arthur HM, Westermann CJ, Disch F, Mager JJ, Snijder RJ, Eichmann A, Mummery CL: Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia. Nat Med. 2010 Apr; 2010 Apr 4. PMID: 20364125

Xu Y, Yuan L, Mak J, Pardanaud L, Caunt M, Kasman I, Larrivée B, Del Toro R, Suchting S, Medvinsky A, Silva J, Yang J, Thomas JL, Koch AW, Alitalo K, Eichmann A, Bagri A: Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3. J Cell Biol. 2010 Jan 11. PMID: 20065093

Corsi JM, Houbron C, Billuart P, Brunet I, Bouvrée K, Eichmann A, Girault JA, Enslen H: Autophosphorylation-independent and -dependent functions of focal adhesion kinase during development. J Biol Chem. 2009 Dec 11; 2009 Sep 23. PMID: 19776009

Pardanaud L, Eichmann A: Stem cells: The stress of forming blood cells. Nature. 2009 Jun 25. PMID: 19553988

Suchting S, Eichmann A: Jagged gives endothelial tip cells an edge. Cell. 2009 Jun 12. PMID: 19524499

Larrivée B, Freitas C, Suchting S, Brunet I, Eichmann A: Guidance of vascular development: lessons from the nervous system. Circ Res. 2009 Feb 27. PMID: 19246687

Jones EA, Yuan L, Breant C, Watts RJ, Eichmann A: Separating genetic and hemodynamic defects in neuropilin 1 knockout embryos. Development. 2008 Aug; 2008 Jun 11. PMID: 18550715

Tammela T, Zarkada G, Wallgard E, Murtomäki A, Suchting S, Wirzenius M, Waltari M, Hellström M, Schomber T, Peltonen R, Freitas C, Duarte A, Isoniemi H, Laakkonen P, Christofori G, Ylä-Herttuala S, Shibuya M, Pytowski B, Eichmann A, Betsholtz C, Alitalo K: Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature. 2008 Jul 31; 2008 Jun 25. PMID: 18594512

Bouvrée K, Larrivée B, Lv X, Yuan L, DeLafarge B, Freitas C, Mathivet T, Bréant C, Tessier-Lavigne M, Bikfalvi A, Eichmann A, Pardanaud L: Netrin-1 inhibits sprouting angiogenesis in developing avian embryos. Dev Biol. 2008 Jun 1; 2008 Mar 26. PMID: 18439993

Freitas C, Larrivée B, Eichmann A: Netrins and UNC5 receptors in angiogenesis. Angiogenesis. 2008; 2008 Feb 12. PMID: 18266062

Larrivée B, Freitas C, Trombe M, Lv X, Delafarge B, Yuan L, Bouvrée K, Bréant C, Del Toro R, Bréchot N, Germain S, Bono F, Dol F, Claes F, Fischer C, Autiero M, Thomas JL, Carmeliet P, Tessier-Lavigne M, Eichmann A: Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis. Genes Dev. 2007 Oct 1. PMID: 17908930

Suchting S, Freitas C, Eichmann A: [Angiogenesis under Delta-Notch couple control]. Med Sci (Paris). 2007 Apr. PMID: 17433219

Virji-Babul N, Eichmann A, Kisly D, Down J, Haslam RH: Use of health care guidelines in patients with Down syndrome by family physicians across Canada. Paediatr Child Health. 2007 Mar. PMID: 19030356

Suchting S, Freitas C, le Noble F, Benedito R, Bréant C, Duarte A, Eichmann A: The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proc Natl Acad Sci U S A. 2007 Feb 27; 2007 Feb 12. PMID: 17296941

Suchting S, Freitas C, le Noble F, Benedito R, Bréant C, Duarte A, Eichmann A: Negative regulators of vessel patterning. Novartis Found Symp. 2007. PMID: 18300415

Jones EA, le Noble F, Eichmann A: What determines blood vessel structure? Genetic prespecification vs. hemodynamics. Physiology (Bethesda). 2006 Dec. PMID: 17119151

Pardanaud L, Eichmann A: Identification, emergence and mobilization of circulating endothelial cells or progenitors in the embryo. Development. 2006 Jul; 2006 May 25. PMID: 16728473

Nguyen TH, Eichmann A, Le Noble F, Fleury V: Dynamics of vascular branching morphogenesis: the effect of blood and tissue flow. Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Jun; 2006 Jun 14. PMID: 16906864

Suchting S, Bicknell R, Eichmann A: Neuronal clues to vascular guidance. Exp Cell Res. 2006 Mar 10; 2005 Dec 5. PMID: 16330027

Le Bras B, Barallobre MJ, Homman-Ludiye J, Ny A, Wyns S, Tammela T, Haiko P, Karkkainen MJ, Yuan L, Muriel MP, Chatzopoulou E, Bréant C, Zalc B, Carmeliet P, Alitalo K, Eichmann A, Thomas JL: VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain. Nat Neurosci. 2006 Mar; 2006 Feb 5. PMID: 16462734

Klagsbrun M, Eichmann A: A role for axon guidance receptors and ligands in blood vessel development and tumor angiogenesis. Cytokine Growth Factor Rev. 2005 Aug-Oct. PMID: 15979925

Eichmann A, Makinen T, Alitalo K: Neural guidance molecules regulate vascular remodeling and vessel navigation. Genes Dev. 2005 May 1. PMID: 15879551

Eichmann A, Le Noble F, Autiero M, Carmeliet P: Guidance of vascular and neural network formation. Curr Opin Neurobiol. 2005 Feb. PMID: 15721752

Hagedorn M, Javerzat S, Gilges D, Meyre A, de Lafarge B, Eichmann A, Bikfalvi A: Accessing key steps of human tumor progression in vivo by using an avian embryo model. Proc Natl Acad Sci U S A. 2005 Feb 1; 2005 Jan 21. PMID: 15665100

Eichmann A, Yuan L, Moyon D, Lenoble F, Pardanaud L, Breant C: Vascular development: from precursor cells to branched arterial and venous networks. Int J Dev Biol. 2005. PMID: 15906240

Lu X, Le Noble F, Yuan L, Jiang Q, De Lafarge B, Sugiyama D, Bréant C, Claes F, De Smet F, Thomas JL, Autiero M, Carmeliet P, Tessier-Lavigne M, Eichmann A: The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature. 2004 Nov 11; 2004 Oct 27. PMID: 15510105

Suzuki Y, Komi Y, Ashino H, Yamashita J, Inoue J, Yoshiki A, Eichmann A, Amanuma H, Kojima S: Retinoic acid controls blood vessel formation by modulating endothelial and mural cell interaction via suppression of Tie2 signaling in vascular progenitor cells. Blood. 2004 Jul 1; 2004 Mar 16. PMID: 15026310

Eichmann A, LeNoble F, Pardanaud L: [Arteriovenous differentiation: genetics or hemodynamics?]. Med Sci (Paris). 2004 Jun-Jul. PMID: 15329806

Tournaire R, Simon MP, le Noble F, Eichmann A, England P, Pouysségur J: A short synthetic peptide inhibits signal transduction, migration and angiogenesis mediated by Tie2 receptor. EMBO Rep. 2004 Mar; 2004 Feb 20. PMID: 14978510

le Noble F, Moyon D, Pardanaud L, Yuan L, Djonov V, Matthijsen R, Bréant C, Fleury V, Eichmann A: Flow regulates arterial-venous differentiation in the chick embryo yolk sac. Development. 2004 Jan; 2003 Dec 17. PMID: 14681188

Wilting J, Christ B, Yuan L, Eichmann A: Cellular and molecular mechanisms of embryonic haemangiogenesis and lymphangiogenesis. Naturwissenschaften. 2003 Oct; 2003 Sep 17. PMID: 14564401

Jilani SM, Murphy TJ, Thai SN, Eichmann A, Alva JA, Iruela-Arispe ML: Selective binding of lectins to embryonic chicken vasculature. J Histochem Cytochem. 2003 May. PMID: 12704207

Yuan L, Moyon D, Pardanaud L, Bréant C, Karkkainen MJ, Alitalo K, Eichmann A: Abnormal lymphatic vessel development in neuropilin 2 mutant mice. Development. 2002 Oct. PMID: 12361971

Eichmann A, Pardanaud L, Yuan L, Moyon D: Vasculogenesis and the search for the hemangioblast. J Hematother Stem Cell Res. 2002 Apr. PMID: 11983094