Martin A Schwartz PhD

Robert W. Berliner Professor of Medicine (Cardiology) and Professor of Cell Biology

Research Interests

Integrin signaling; Mechanotransduction; Atherosclerosis; Vascular remodeling; Heart disease; Extracellular matrix; Cell adhesion; Cytoskeleton; Cell-cell junctions; Fluid shear stress


Selected Publications

  • Conway DE, Breckenridge MT, Hinde E, Gratton E, Chen CS, Schwartz MA. Fluid Shear Stress on Endothelial Cells Modulates Mechanical Tension across VE-Cadherin and PECAM-1. Curr Biol. 2013 Jun 3;23(11):1024-30
  • Grashoff C., Hoffman BD., Brenner MD., Zhou R., Parsons M., Yang MT., McLean MA., Sligar SG., Chen CS., Ha T. and Schwartz, MA.. Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics. Nature, 2010,466:263-6.
  • Gaus K, Le Lay S, Balasubramanian N, Schwartz MA. Integrin-mediated adhesion regulates membrane order. J Cell Biol. 2006,174:725-734.
  • Miguel A. del Pozo, Nagaraj Balasubramanian, Nazilla B. Alderson, William B. Kiosses, Araceli Grande-García, Richard G.W. Anderson and Martin A. Schwartz. Phospho-Caveolin-1 Mediates Integrin-Regulated Membrane Domain Internalization. Nat. Cell Biol. 2005,7:901-8.
  • Orr, A.W., Sanders, J.M., Bevard, M., Coleman, E., Sarembock, I.J., Schwartz, M.A. The subendothelial extracellular matrix modulates NF-kappaB activation by flow: a potential role in atherosclerosis. J Cell Biol. 2005,169:191-202.
  • Tzima, El, Irani-Tehrani, M., Kiosses, W.B., Dejana, E., Schultz, D.A., Engelhardt, B., Cao, G., DeLisser, H., Schwartz, M.A.(2005) Identification of a mechanosensory complex that mediates the endothelial cell response to fluid shear stress. Nature 437:426-30.

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