Daniel Goldstein, MBBS

Director, Center for the Biology of Aging and Cardiovascular Diseases

Departments & Organizations

HTI

Immunology and Immunotherapy

Internal Medicine: General & Advanced Heart Failure Program | Rheumatic Diseases Research Core | Yale Cardiovascular Research Center

Vascular Biology and Therapeutics Program

Yale Center for Advanced Heart Failure, Mechanical Circulatory Support, and Heart Transplantation

Office of Cooperative Research

Biography

As a transplant physician, I have investigated the mechanisms and consequences of innate immune activation after organ transplantation. My laboratory was the first to demonstrate that Toll like receptor signaling via MyD88 accelerated the tempo of acute transplant rejection (JCI, 2003, AJT, 2004) and impaired transplant tolerance (JI, 2006, JASN, 2008). These were some of the first studies to show that Toll like receptors activate inflammation in sterile in vivo models. The activators of the innate immune system after transplantation have remained elusive. We recently discovered that haptoglobin stimulates innate immunity to induce inflammation after organ transplantation (JCI, 2012). As a result of our work some laboratories and pharmaceutical companies are targeting innate immune pathways to reduce inflammation after organ transplantation.

I am also interested in how aging impacts immunity, initially to determine if older transplant recipients exhibit altered immune responses to transplantation. My laboratory challenged the paradigm that declining immune function is responsible for age-associated disorders. In murine viral infection models, we determined that exaggerated IL-17 production by NKT cells induces lethal immune pathology (Cell Host and Microbe, 2009). In murine vascular models, we demonstrated that elevated inflammatory responses by vascular smooth muscle cells may predispose to atherosclerosis (ATVB, 2012). Finally, in murine transplant models we documented that enhanced responses by naïve CD8+ T cells may impair immune tolerance with aging (JI, 2011). In sum, we have made innovative findings, challenging current paradigms, that elevated immune responses explain age-associated phenotypes.

Education & Training

MBBS University of London (1992)
Resident Johns Hopkins Bayview Medical Center
Fellow University of Alabama- Birmingham
Fellow University of Alabama- Birmingham

Honors & Recognition

  • Academic Leadership AwardNIH/NIA (2015)

  • Sir William Osler Young Investigator Award, Interurban Clinical Club (2012)

  • MemberAmerican Society of Clinical Investigation (2010)

  • Established Investigator AwardAmerican Heart Association (2009)

  • NIA Mid Career Development AwardNational Institute on Aging (2008)

  • Basic Scientist AwardAmerican Society of Tansplantation (2007)

Professional Service

  • NIH Study Section CMAD (2014)

  • Section Editor Aging Cell (2013)

  • - Board of Directors: International Society for Heart and Lung Transplantation (2013)

  • (2009 - 2013) Section Editor, Journal of Immunoloy

  • NIH (2008 - 2012) NIH Study Section TTT

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Contact Info

Daniel Goldstein, MBBS
Patient Care Locations
Yale Congestive Heart FailureYale Physicians Building
800 Howard Avenue, Ste 2nd floor

New Haven, CT 06519
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Yale CardiologyLaboratory for Medicine and Pediatrics (LMP)
15 York Street

New Haven, CT 06510
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Office Location
The Anlyan Center
300 Cedar Street

New Haven, CT 06519
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Mailing Address
PO Box 208056
333 Cedar Street

New Haven, CT 06520-8056

Curriculum Vitae