Arya Mani MD, FACC

Associate Professor of Medicine (Cardiology) and of Genetics; Director, Cardiovascular Genetics Program

Biographical Info

My laboratory’s major focus is the identification of genetic causes of major cardiovascular disorders and the elucidation of their pathophysiology. Through collaborative efforts with physicians and scientist across the world we have recruited large populations of patients and families with early onset coronary artery disease and metabolic syndrome and have successfully mapped and identified number of genes for these diseases. An ongoing effort in the laboratory is to understand the function of these genes and how the mutations affect the phenotype.

Having unique access to the genetic study population, we have had the opportunity to carry out clinical studies to investigate the disease mechanisms and have made numerous novel discoveries. We have also generated a mouse model of these mutations and are actively investigating pathways that regulate insulin signaling, glucose metabolism, VLDL and LDL syntheis and clearance and atherosclerosis.

International Activity

  • The genetic etiology of coronary artery disease
    Mombay, India(2001)
    Identification of genetic causes of premature coronary artery disease in South Asians
  • Genetics of Cardiovascular Diseases
    Tehran, Iran; Isfahan, Iran; Shiraz, Iran(1998)
    Study of genetic causes of coronary artery disease and congenital heart defect

Education & Training

Johannes-Gutenberg-University of Mainz (1991)
Yale-New Haven Hospital, Internal Medicine (1993 - 1996)
University of Erlangen-Nuernberg, Nephrology
Yale University School of Medicine, Cardiovascular Medicine (1997 - 2001)
Board Certification
Cardiovascular Disease, Board Certified  (2001)
Board Certification
Nuclear Cardiology, Board Certified  (2000)
Board Certification
Internal Medicine, Board Certified  (1996)

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