General and Preventive Cardiology


The Yale-New Haven Hospital Center for Outcomes Research and Evaluation (CORE) conducts numerous clinical studies to determine optimal treatment strategies and identify opportunities for improvement in the prevention, treatment and outcomes of cardiovascular disease.

In addition to CORE-driven outcomes research, studies on the role of stress and emotion in the pathophysiology of cardiovascular disease are also underway in the Section of Cardiology.

Current Research

Current and recent general and preventive cardiology research at Yale includes studies investigating:

Gender differences in acute myocardial infarction outcomes

  • VIRGO - A large study of the demographics, risk factors, outcomes, and clinical care of young women with heart attack (and a comparison group of young men)

Effect of mental health and stress interventions on coronary artery disease outcomes

  • Coronary Psychosocial Evaluation Studies (COPES) – A prospective study of the relation between depressive symptoms and all-cause mortality in patients with unstable angina
  • RISTA Trial – A randomized trial testing the effects of stress reduction treatment on the prevalence of shock-treated ventricular arrhythmias in patients with ICD implants


Bio Profile

Matthew Burg, PhD

Medical School Recruit in Internal Medicine (Cardiology)

Associate Professor of Medicine and Anesthesiology

Bio Profile

Harlan Krumholz, MD, SM

Harold H. Hines, Jr. Professor of Medicine (Cardiology) and Professor in the Institute for Social and Policy Studies, of Investigative Medicine and of Public Health (Health Policy)

Co-Director, Robert Wood Johnson Foundation Clinical Scholars Program, Yale University

Director, Center for Outcomes Research and Evaluation, Yale-New Haven Hospital

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