Heart Failure and Cardiac Transplantation

Overview

Yale has an active transplant program and provides continuity of care to more than 700 outpatients with heart failure.

Current Research

Heart failure and transplant-related research at Yale consists of ten ongoing studies, including investigations of:

Left ventricular assist devices/systems (LVAD/LVAS)

  • DuraHeart LVAS – Evaluation of the safety and effectiveness of the DuraHeart™ left ventricular assist device in patients with advanced heart failure
  • DuraHeart-2 Bridge to Transplant LVAD Trial
  • Levitronix CentriMag VAS Failure-to-Wean from Cardiopulmonary Bypass Trial – Evaluation of the safety and effectiveness of the CentriMag ventricular assist system in patients who have experienced heart failure during surgery and cannot be removed from cardiac bypass.
  • Heartware Destination Therapy Trial – Trial of an LVAD as destination therapy in patients with advanced heart failure who have failed medical therapy and are not eligible for cardiac transplantation
  • INTERMACS - A national registry for patients receiving mechanical circulatory support device therapy to treat advanced heart failure (a joint effort of the NHLBI, CMS, and FDA)

Congestive Heart Failure

  • HEART MATE III - New VAD Device
  • GUIDE IT - Guiding Evidence Based Therapy Using Biomarker Intensified Treatment in Heart Failure
  • FIX HF - Evaluation of the Safety and Efficacy of the OPTIMIZER® System in Subjects with Moderate-to-Severe Heart Failure with Ejection Fraction between 25%and 45%: (FIX-HF-5C)
  • Parachute - A Pivotal Trial to Establish the Efficacy and Long-term Safety of the Parachute Implant System (PARACHUTE IV)
  • WISDOM -An Intervention to Improve Implantable Cardioverter-Defibrillator Deactivation Conversations

Faculty

Bellumkonda, Lavanya

Assistant Professor of Medicine (Cardiology)

Jacoby, Daniel Louis

Assistant Professor of Medicine (Cardiology)
Director, Advanced Heart Failure and Cardiomyopathy
Director, General Heart Failure

Lee, Forrester Ashe

Professor of Medicine (Cardiology)
Associate Dean for Multicultural Affairs

Mangi, Abeel A.

Associate Professor of Surgery (Section of Cardiac Surgery)
Surgical Director, Center for Advanced Heart Failure, Mechanical Circulatory Support and Heart Transplantation
Surgical Director, Trans-Catheter Therapies