Heart Failure and Cardiac Transplantation

Overview

Yale has an active transplant program and provides continuity of care to more than 700 outpatients with heart failure.

Current Research

Heart failure and transplant-related research at Yale consists of six ongoing studies, including investigations of:

Left ventricular assist devices/systems (LVAD/LVAS)

  • DuraHeart LVAS – Evaluation of the safety and effectiveness of the DuraHeart™ left ventricular assist device in patients with advanced heart failure

  • DuraHeart-2 Bridge to Transplant LVAD Trial

  • Levitronix CentriMag VAS Failure-to-Wean from Cardiopulmonary Bypass Trial – Evaluation of the safety and effectiveness of the CentriMag ventricular assist system in patients who have experienced heart failure during surgery and cannot be removed from cardiac bypass.

  • Heartware Destination Therapy Trial – Trial of an LVAD as destination therapy in patients with advanced heart failure who have failed medical therapy and are not eligible for cardiac transplantation

  • HeartMate III – Evaluation of the Heartmate III LVAD, featuring a magnetically levitated impeller

  • INTERMACS - A national registry for patients receiving mechanical circulatory support device therapy to treat advanced heart failure (a joint effort of the NHLBI, CMS, and FDA)

Faculty