Endovascular and Peripheral Intervention

Overview

Endovascular and peripheral interventions are a rapidly evolving area of clinical research at Yale. Yale-New Haven Hospital performs over 500 invasive peripheral diagnostic procedures and more than 300 peripheral interventions annually.

Our physicians perform the full range of diagnostic and therapeutic procedures, including iliac, femoral, renal, carotid, subclavian, and aortic interventions. We employ the latest treatment and imaging modalities, including intravascular ultrasound, atherectomy, thrombectomy, distal protection, laser, crossing devices, and re-entry devices.

Current Research

Current endovascular and peripheral interventional research consists of seven active studies. Ongoing and recent studies include investigations of:

Drug-coated/drug-eluting balloons

  • LEVANT 2 – A comparison of a drug-coated balloon with standard balloon angioplasty for the treatment of femoro-popliteal artery lesions

Peripheral stents

  • Bioflex-I Trial – IDE trial of two new stents to treat femoro-popliteal and iliac artery lesions
  • TIGRIS – Evaluation of a vascular stent in the treatment of atherosclerotic lesions in the superficial femoral and proximal popliteal arteries

Peripheral stent grafts

  • Investigation of a novel polytetrafluoroethylene (PTFE) superficial femoral artery (SFA) stent graft
  • ASPECT- FDA-supported comparison of commercially available peripheral stents

Carotid stenting and embolic protection systems

  • CHOICE – Post market surveillance of carotid stent and embolic protection systems in high-risk surgical patients

Transcatheter renal denervation therapy

  • Symplicity HTN-3 – Randomized trial of the safety and effectiveness of percutaneous renal denervation in subjects with uncontrolled hypertension

Arterial anatomy and erectile dysfunction (ED)

  • IMPASSE – A long-term observational study to determine the prevalence of angiographically-identifiable erectile-related artery atherosclerosis in men with known or suspected coronary or peripheral artery disease

Atherectomy

  • JET Registry – Postmarket surveillance registry of a combined-treatment catheter for the treatment of diffuse occlusive PAD

Faculty