Michael Simons MD, FACC, FAHA

Robert W. Berliner Professor of Medicine (Cardiology) and Professor of Cell Biology; Director, Yale Cardiovascular Research Center

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development | Molecular Medicine, Pharmacology, and Physiology

Vascular Biology and Therapeutics Program

Animal Organogenesis

Cell Biology: Developmental Cell Biology and Genetics

Internal Medicine: Cardiovascular Medicine: Yale Cardiovascular Clinical Research; Yale Cardiovascular Research Center | Simons Lab


Research Interests

Angiogenesis; Arteriogenesis; Lymphangiogenesis; Endothelial Signaling; tyrosine kinase signaling; vascular development; FGF; VEGF; endocytosis   more...


Education

  • B.S., Massachusetts Institute of Technology, 1980
  • M.D., Yale University, 1984

Selected Publications

  • Tirziu D, Jaba IM, Yu P, Larrivée B, Coon BG, Cristofaro B, Zhuang ZW, Lanahan AA, Schwartz MA, Eichmann A and Simons M. Endothelial NFkB -dependent regulation of arteriogenesis and branching. Circulation 2012; 126:2589-2600. http://f1000.com/prime/717963744bd=1"
  • Chen P-Y*, Qin L*, Barnes C, Charisse K, Yi T, Zhang X, Ali R, Medina PP, Yu J, Slack FJ, Anderson DG, Kotelianski V, Wang F, Tellides G, Simons M. FGF regulates TGFß signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression. Cell Reports 2012; http://dx.doi.org/10.1016/j.celrep.2012.10.021.
  • Elfenbein A, Lanahan AA, Zhou TX, Yamasaki A, Tkachenko E, Matsuda M, Simons M. Syndecan 4 regulates endothelial FGFR1 signaling by directing macropinocytosis. Science Signaling 2012; 5:ra36. doi: 10.1126/scisignal.2002495

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