Faculty


Zheng, Tao

Associate Professor of Medicine (Immunology) and of Pediatrics (Immunology); Chief, Section of Allergy and Clinical Immunology


Askenase, Philip William

Professor of Medicine (Immunology)

Research Interests: Our focus is newly recognized extracellular nanovesicles called exosomes (100 nanometers across; one 500th the size of cells) that are made by all cells, present in all fluids and made in some form by all species down to and including bacteria and fungi. Remarkably, they transfer small RNAs between cells, particularly miRNAs, to then function genetically in the acceptor cells. Our system has been CD8+ suppressor T cells that make antigen specific exosomes due to a coating of immunoglobulin light chains that are induced by antigen high dose tolerance to suppress effector T cells. Our initial system was the mouse model of allergic cutaneous contact hypersensitivity dermatitis (poison ivy), but now has been extended to delayed-type hypersensitivity (DTH) to the protein antigen ovalbumin. A remarkable aspect of this system is that these tiny vesicles that contain only 0.2 attoliters carry miRNA at zeptomolar concentration to function in vivo in an endocrine manner to genetically alter the function of distant effector T cells at the site of active responses. This new cell to cell communication system, that seems fundamental to life, has led us to now investigate exosome treatment by the intranasal route where the vesicles cross the dorsal anterior sinus cribriform plate to then pass the blood barrier and strongly inhibit the mouse model of autoimmune multiple sclerosis. Further, we are contemplating use of healing mesenchymal stem cell exosomes for similar treatment of neuropsychiatric diseases, such as autism. It is interesting that basic allergy research on poison ivy has led to consideration of entirely new therapies for multiple sclerosis and autism.

  • Office: (203) 785-6566

Eisenbarth, Stephanie C

Assistant Professor of Laboratory Medicine, of Immunobiology and of Medicine (Immunology)
Assistant Director, Clinical Immunology & Flow Cytometry Laboratories
Director, Immune Monitoring Core

Research Interests: Pattern Recognition Receptors; NOD-like Receptors (NLRs); Dendritic Cells; T cells; Allergy/Asthma; Vaccines/Adjuvants; Red Blood Cell Alloimmunization; Autoimmune Diabetes; Influenza

Clinical Interests: The Clinical Immunology Laboratory integrates standard diagnostic immunology testing with an active flow cytometry and molecular diagnostics laboratory and therefore services a large and diverse patient population. The Immune Monitoring Core provides a core resource for clinical and translational research protocols at Yale School of Medicine that involve immunotherapy and/or that affect the human immune system. In addition to performing assays beyond the scope of routine clinical tests, this facility is involved in developing and utilizing new technologies and assays as needed for basic and clinical human studies on-going at Yale.

  • Office: (203) 737-4188
  • Lab: (203) 737-7680

Hsu, F. Ida

Clinician - Internal Medicine (Immunology)

Clinical Interests: Allergic rhinitis; asthma; food allergy; drug allergy; urticaria (hives); angioedema (hereditary and idiopathic); anaphylaxis; common variable immune deficiency (CVID); eosinophilic disorders (EGID and hypereosinophilic syndromes). Patients interested in comprehensive allergy testing (environmental, food or drug allergy) are best seen at the North Haven office (203-287-6200). Dr. Hsu provides aspirin desensitization to patients with aspirin-sensitive asthma with nasal polyps (aka aspirin-exacerbated respiratory disease or Samter's triad) at the Winchester Chest Clinic (203-785-4198). Patients with asthma, hives, angioedema (allergic swelling), or needing evaluation for immune deficiency may be seen at either location.

  • Office: (203) 785-4170
  • Appt: (203) 287-6200

Kantor, Fred Stuart

Paul B. Beeson Professor of Medicine (Immunology)

Research Interests: Host parasite relationship in Lyme Borreliosis; immune relationship between Borrelia burgdorferi and the host in chronic infection

Clinical Interests: Vasculitis; immunodeficiency; allergic rhinitis and asthma; systemic anaphylaxis

  • Office: (203) 785-4170
  • Appt: (203) 287-6200

Lobo, Francis Matthew

Clinical Instructor in Pediatrics (Immunology) and Residential College Associate Fellow in Faculty of Arts and Sciences

Clinical Interests: immune deficiency, urticaria and angioedema, drug allergy, food allergy, allergy skin testing, asthma, allergy vaccine immunotherapy

  • Office: (203) 785-4170
  • Appt: (203) 287-6200

Meffre, Eric RF

Associate Professor of Immunobiology and of Medicine (Immunology)

Research Interests: Human B-cell tolerance; Primary immunodeficiencies; Autoimmune diseases

  • Office: (203) 737-4535

Price, Christina

Assistant Professor of Medicine (Immunology) and Instructor in Pediatrics (Immunology)
Associate Program Director, Allergy and Clinical Immunology Fellowship

Research Interests: Immune Deficiency in Autoimmunity; antibody defects

Clinical Interests: Immunodeficiency including common variable immune deficiency (CVID); selective antibody deficiency and secondary immune deficiency; urticaria (hives); allergic rhinitis and asthma; systemic anaphylaxis; food allergy; drug allergy.

  • Appt: (203) 287-6200

Rodenas, Mario

Clinician Int Med Immunology and Pediatrics

Clinical Interests: Allergic rhinoconjunctivitis, drug allergy, urticaria and angioedema, food allergy, stinging insect allergy, vaccine allergy, connective tissue disorders, occupational diseases, allergy skin testing including patch testing and allergen immunotherapy.

  • Appt: (203) 287-6200

Romberg, Neil David

Assistant Professor of Pediatrics (Immunology)

Research Interests: Molecular mechanisms of primary immune deficiency diseases, Autoimmune manifestations of Common Variable Immune Deficiency, Smith-Magenis Syndrome related immune deficiency, Newborn screening for immune deficiency

Clinical Interests: The Diagnosis and Management of Inherited Immune Deficiency diseases including: Severe Combined Immune Deficiency, Hyper-IgM syndromes, Hyper-IgE syndromes, 22q11.2 deletion syndrome (DiGeorge or VCF Syndrome), Wiskott-Aldrich Syndrome, Chronic Mucocutaneuos Candidiasis, X-linked Agammaglobulinemia, Common Variable Immune deficiency, Smith-Magenis Syndrome related immune deficiency, Complement Deficiency, Chronic Granulomatous Disease, Leukocyte Adhesion Defects, Deficiencies of the Innate Immune System. The Diagnosis and Management of Auto-inflammatory Diseases (periodic fever syndromes) including Familial Mediterranean Fever (FMF), Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS), Deficiency of the Interleukin-1 Receptor Antagonist (DIRA) and Cryopyrin-Associated Periodic Syndromes (CAPS).

  • Appt: (203) 785-4081

Zheng, Tao

Associate Professor of Medicine (Immunology) and of Pediatrics (Immunology)
Chief, Section of Allergy and Clinical Immunology

Research Interests: Characterization of molecular and cellular mechanisms in the pathogenesis of atopic dermatitis; Development of asthma; Atopic March; Using transgenic animal models; Th2 cytokine IL-13 as a potent inducer of phenotypical features of atopic dermatitis in mice, eosinophil, mast cell, and T cell infiltration, fibrotic and vascular remodeling, and clinical manifestations; IL-13 induced atopic dermatitis; Enhanced susceptibility of these mice to allergen induced allergic asthma in the lung; Identifying novel molecules and pathways in the pathogenesis of atopic dermatitis and the atopic march; Developing new therapeutics for allergic diseases

Clinical Interests: Adverse reactions to food and drugs, allergic conjunctivitis, allergic rhinitis, anaphylaxis, angioedema, asthma, eczema (atopic dermatitis), eosinophilia, hives (urticaria), insect sting allergy, mastocytosis, nasal polyposis, non-AIDS-related deficiencies of the immune system, sinusitis.

  • Office: (203) 785-4170
  • Appt: (203) 287-6200

Zhu, Zhou

Associate Professor of Pediatrics (Immunology) and of Medicine (Immunology)

Research Interests: Our studies are on glycoligand receptors, siglecs, that are expressed on the immune cells such as eosinophils (Siglec-8) and neutrophils (Siglec-9) in specific pulmonary diseases. The unique expression patterns of these siglecs, the specific binding to glycoligands, and the consequent cellular responses, including apoptosis, are being explored as potential targets and pathways for the development of effective therapeutic approaches for pulmonary diseases such as asthma and COPD.

         

    Hsu, F. Ida

    Clinician - Internal Medicine (Immunology)

    Clinical Interests: Allergic rhinitis; asthma; food allergy; drug allergy; urticaria (hives); angioedema (hereditary and idiopathic); anaphylaxis; common variable immune deficiency (CVID); eosinophilic disorders (EGID and hypereosinophilic syndromes). Patients interested in comprehensive allergy testing (environmental, food or drug allergy) are best seen at the North Haven office (203-287-6200). Dr. Hsu provides aspirin desensitization to patients with aspirin-sensitive asthma with nasal polyps (aka aspirin-exacerbated respiratory disease or Samter's triad) at the Winchester Chest Clinic (203-785-4198). Patients with asthma, hives, angioedema (allergic swelling), or needing evaluation for immune deficiency may be seen at either location.

    • Office: (203) 785-4170
    • Appt: (203) 287-6200

    Kantor, Fred Stuart

    Paul B. Beeson Professor of Medicine (Immunology)

    Research Interests: Host parasite relationship in Lyme Borreliosis; immune relationship between Borrelia burgdorferi and the host in chronic infection

    Clinical Interests: Vasculitis; immunodeficiency; allergic rhinitis and asthma; systemic anaphylaxis

    • Office: (203) 785-4170
    • Appt: (203) 287-6200

    Lobo, Francis Matthew

    Clinical Instructor in Pediatrics (Immunology) and Residential College Associate Fellow in Faculty of Arts and Sciences

    Clinical Interests: immune deficiency, urticaria and angioedema, drug allergy, food allergy, allergy skin testing, asthma, allergy vaccine immunotherapy

    • Office: (203) 785-4170
    • Appt: (203) 287-6200

    Price, Christina

    Assistant Professor of Medicine (Immunology) and Instructor in Pediatrics (Immunology)
    Associate Program Director, Allergy and Clinical Immunology Fellowship

    Research Interests: Immune Deficiency in Autoimmunity; antibody defects

    Clinical Interests: Immunodeficiency including common variable immune deficiency (CVID); selective antibody deficiency and secondary immune deficiency; urticaria (hives); allergic rhinitis and asthma; systemic anaphylaxis; food allergy; drug allergy.

    • Appt: (203) 287-6200

    Rodenas, Mario

    Clinician Int Med Immunology and Pediatrics

    Clinical Interests: Allergic rhinoconjunctivitis, drug allergy, urticaria and angioedema, food allergy, stinging insect allergy, vaccine allergy, connective tissue disorders, occupational diseases, allergy skin testing including patch testing and allergen immunotherapy.

    • Appt: (203) 287-6200

    Romberg, Neil David

    Assistant Professor of Pediatrics (Immunology)

    Research Interests: Molecular mechanisms of primary immune deficiency diseases, Autoimmune manifestations of Common Variable Immune Deficiency, Smith-Magenis Syndrome related immune deficiency, Newborn screening for immune deficiency

    Clinical Interests: The Diagnosis and Management of Inherited Immune Deficiency diseases including: Severe Combined Immune Deficiency, Hyper-IgM syndromes, Hyper-IgE syndromes, 22q11.2 deletion syndrome (DiGeorge or VCF Syndrome), Wiskott-Aldrich Syndrome, Chronic Mucocutaneuos Candidiasis, X-linked Agammaglobulinemia, Common Variable Immune deficiency, Smith-Magenis Syndrome related immune deficiency, Complement Deficiency, Chronic Granulomatous Disease, Leukocyte Adhesion Defects, Deficiencies of the Innate Immune System. The Diagnosis and Management of Auto-inflammatory Diseases (periodic fever syndromes) including Familial Mediterranean Fever (FMF), Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS), Deficiency of the Interleukin-1 Receptor Antagonist (DIRA) and Cryopyrin-Associated Periodic Syndromes (CAPS).

    • Appt: (203) 785-4081

    Zheng, Tao

    Associate Professor of Medicine (Immunology) and of Pediatrics (Immunology)
    Chief, Section of Allergy and Clinical Immunology

    Research Interests: Characterization of molecular and cellular mechanisms in the pathogenesis of atopic dermatitis; Development of asthma; Atopic March; Using transgenic animal models; Th2 cytokine IL-13 as a potent inducer of phenotypical features of atopic dermatitis in mice, eosinophil, mast cell, and T cell infiltration, fibrotic and vascular remodeling, and clinical manifestations; IL-13 induced atopic dermatitis; Enhanced susceptibility of these mice to allergen induced allergic asthma in the lung; Identifying novel molecules and pathways in the pathogenesis of atopic dermatitis and the atopic march; Developing new therapeutics for allergic diseases

    Clinical Interests: Adverse reactions to food and drugs, allergic conjunctivitis, allergic rhinitis, anaphylaxis, angioedema, asthma, eczema (atopic dermatitis), eosinophilia, hives (urticaria), insect sting allergy, mastocytosis, nasal polyposis, non-AIDS-related deficiencies of the immune system, sinusitis.

    • Office: (203) 785-4170
    • Appt: (203) 287-6200
         

    Gruskay, Frank Louis

    Associate Clinical Professor of Pediatrics (Immunology)

    Clinical Interests: allergic and immunologic disorders in children

      Lobo, Francis Matthew

      Clinical Instructor in Pediatrics (Immunology) and Residential College Associate Fellow in Faculty of Arts and Sciences

      Clinical Interests: immune deficiency, urticaria and angioedema, drug allergy, food allergy, allergy skin testing, asthma, allergy vaccine immunotherapy

      • Office: (203) 785-4170
      • Appt: (203) 287-6200

      Matczuk, Agnieszka

      Assistant Clinical Professor of Pediatrics

      Clinical Interests: primary immunodeficiency; food allergy; atopic dermatitis; allergic asthma.

      • Appt: (203) 785-4081

      Price, Christina

      Assistant Professor of Medicine (Immunology) and Instructor in Pediatrics (Immunology)
      Associate Program Director, Allergy and Clinical Immunology Fellowship

      Clinical Interests: Immunodeficiency including common variable immune deficiency (CVID); selective antibody deficiency and secondary immune deficiency; urticaria (hives); allergic rhinitis and asthma; systemic anaphylaxis; food allergy; drug allergy.

      • Appt: (203) 287-6200

      Rodenas, Mario

      Clinician Int Med Immunology and Pediatrics

      Clinical Interests: Allergic rhinoconjunctivitis, drug allergy, urticaria and angioedema, food allergy, stinging insect allergy, vaccine allergy, connective tissue disorders, occupational diseases, allergy skin testing including patch testing and allergen immunotherapy.

      • Appt: (203) 287-6200

      Romberg, Neil David

      Assistant Professor of Pediatrics (Immunology)

      Clinical Interests: The Diagnosis and Management of Inherited Immune Deficiency diseases including: Severe Combined Immune Deficiency, Hyper-IgM syndromes, Hyper-IgE syndromes, 22q11.2 deletion syndrome (DiGeorge or VCF Syndrome), Wiskott-Aldrich Syndrome, Chronic Mucocutaneuos Candidiasis, X-linked Agammaglobulinemia, Common Variable Immune deficiency, Smith-Magenis Syndrome related immune deficiency, Complement Deficiency, Chronic Granulomatous Disease, Leukocyte Adhesion Defects, Deficiencies of the Innate Immune System. The Diagnosis and Management of Auto-inflammatory Diseases (periodic fever syndromes) including Familial Mediterranean Fever (FMF), Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS), Deficiency of the Interleukin-1 Receptor Antagonist (DIRA) and Cryopyrin-Associated Periodic Syndromes (CAPS).

      • Appt: (203) 785-4081

      Zhu, Zhou

      Associate Professor of Pediatrics (Immunology) and of Medicine (Immunology)

             

        Askenase, Philip William

        Professor of Medicine (Immunology)

        Research Interests: Our focus is newly recognized extracellular nanovesicles called exosomes (100 nanometers across; one 500th the size of cells) that are made by all cells, present in all fluids and made in some form by all species down to and including bacteria and fungi. Remarkably, they transfer small RNAs between cells, particularly miRNAs, to then function genetically in the acceptor cells. Our system has been CD8+ suppressor T cells that make antigen specific exosomes due to a coating of immunoglobulin light chains that are induced by antigen high dose tolerance to suppress effector T cells. Our initial system was the mouse model of allergic cutaneous contact hypersensitivity dermatitis (poison ivy), but now has been extended to delayed-type hypersensitivity (DTH) to the protein antigen ovalbumin. A remarkable aspect of this system is that these tiny vesicles that contain only 0.2 attoliters carry miRNA at zeptomolar concentration to function in vivo in an endocrine manner to genetically alter the function of distant effector T cells at the site of active responses. This new cell to cell communication system, that seems fundamental to life, has led us to now investigate exosome treatment by the intranasal route where the vesicles cross the dorsal anterior sinus cribriform plate to then pass the blood barrier and strongly inhibit the mouse model of autoimmune multiple sclerosis. Further, we are contemplating use of healing mesenchymal stem cell exosomes for similar treatment of neuropsychiatric diseases, such as autism. It is interesting that basic allergy research on poison ivy has led to consideration of entirely new therapies for multiple sclerosis and autism.

        Eisenbarth, Stephanie C

        Assistant Professor of Laboratory Medicine, of Immunobiology and of Medicine (Immunology)
        Assistant Director, Clinical Immunology & Flow Cytometry Laboratories
        Director, Immune Monitoring Core

        Research Interests: Pattern Recognition Receptors; NOD-like Receptors (NLRs); Dendritic Cells; T cells; Allergy/Asthma; Vaccines/Adjuvants; Red Blood Cell Alloimmunization; Autoimmune Diabetes; Influenza

        Kantor, Fred Stuart

        Paul B. Beeson Professor of Medicine (Immunology)

        Research Interests: Host parasite relationship in Lyme Borreliosis; immune relationship between Borrelia burgdorferi and the host in chronic infection

        Meffre, Eric RF

        Associate Professor of Immunobiology and of Medicine (Immunology)

        Research Interests: Human B-cell tolerance; Primary immunodeficiencies; Autoimmune diseases

        Price, Christina

        Assistant Professor of Medicine (Immunology) and Instructor in Pediatrics (Immunology)
        Associate Program Director, Allergy and Clinical Immunology Fellowship

        Research Interests: Immune Deficiency in Autoimmunity; antibody defects

        Romberg, Neil David

        Assistant Professor of Pediatrics (Immunology)

        Research Interests: Molecular mechanisms of primary immune deficiency diseases, Autoimmune manifestations of Common Variable Immune Deficiency, Smith-Magenis Syndrome related immune deficiency, Newborn screening for immune deficiency

        Zheng, Tao

        Associate Professor of Medicine (Immunology) and of Pediatrics (Immunology)
        Chief, Section of Allergy and Clinical Immunology

        Research Interests: Characterization of molecular and cellular mechanisms in the pathogenesis of atopic dermatitis; Development of asthma; Atopic March; Using transgenic animal models; Th2 cytokine IL-13 as a potent inducer of phenotypical features of atopic dermatitis in mice, eosinophil, mast cell, and T cell infiltration, fibrotic and vascular remodeling, and clinical manifestations; IL-13 induced atopic dermatitis; Enhanced susceptibility of these mice to allergen induced allergic asthma in the lung; Identifying novel molecules and pathways in the pathogenesis of atopic dermatitis and the atopic march; Developing new therapeutics for allergic diseases

        Zhu, Zhou

        Associate Professor of Pediatrics (Immunology) and of Medicine (Immunology)

        Research Interests: Our studies are on glycoligand receptors, siglecs, that are expressed on the immune cells such as eosinophils (Siglec-8) and neutrophils (Siglec-9) in specific pulmonary diseases. The unique expression patterns of these siglecs, the specific binding to glycoligands, and the consequent cellular responses, including apoptosis, are being explored as potential targets and pathways for the development of effective therapeutic approaches for pulmonary diseases such as asthma and COPD.

             

        Gruskay, Frank Louis

        Associate Clinical Professor of Pediatrics (Immunology)

        Clinical Interests: allergic and immunologic disorders in children

        Kohli-Pamnani, Anita

        Clinical Instructor in Medicine (Immunology)

        Matczuk, Agnieszka

        Assistant Clinical Professor of Pediatrics

        Clinical Interests: primary immunodeficiency; food allergy; atopic dermatitis; allergic asthma.

             

        Dreyfus, David H.

        Associate Clinical Professor of Pediatrics

        Randolph, Christopher

        Clinical Professor of Pediatrics