Research in Allergy and Clinical Immunology at Yale encompasses a wide range of allergic and immunological diseases in pediatric and adult populations. Studies conducted by our faculty include the following areas.
- Primary immune deficiency diseases, newborn screening for immune deficiency
- Autoinflammatory diseases
- B cell functions in immune tolerance and immune deficiency
- Extracellular nanovesicles (Exosomes) mediated mast cell and T cell responses
- Atopic dermatitis, and related Atopic March-progression from skin to the lung
- Host-parasite interactions in and vaccines for Lyme disease
- Pattern recognition receptors and NOD-like receptors in allergy and asthma
- Pro-inflammatory cytokines in asthma and allergy
- Sialoglyco ligand binding receptors (Siglecs) in inflammatory lung diseases
- Regulation of anaphylactic responses
In these studies, our investigators are seeking to answer the most fundamental questions in allergic and immunological diseases by elucidating the underlying molecular and cellular mechanisms. Knowledge from these studies will enable us to develop novel methods for more efficient and accurate diagnosis and, ultimately, more effective treatment for these diseases. In these studies, different approaches are taken. Some studies directly involve patients in the clinic, such as newborn screening and treatment for immune deficiency; some require analyses of patient samples for further understanding; yet others can be more mechanistic or for pre-clinic testing of novel therapies utilizing animal models.
For several decades, fellows in training in Allergy and Clinical Immunology at Yale have a wide range of research opportunities and choice of mentorship. Fellows are able to choose a mentor to work with from the Section of Allergy and Clinical Immunology, or from other sections, within Internal Medicine. Investigators from other departments, such as Immunobiology, at Yale School of Medicine are also available.
Please see our Faculty Page for a list of research faculty.