João P. Pereira PhD
Assistant Professor of Immunobiology
Immunology; Hematopoiesis; B-lymphocyte development; Bone marrow niches; Cell migration
Research in this laboratory is focused on several aspects related to hematopoiesis, a fundamental and complex cell differentiation process that generates many different cell types including all blood cells. With the exception of T-lymphocytes, all other hematopoietic cells are predominantly generated in the bone marrow of adult mammals. Central to this process are the bone marrow niches where immune cells develop. These are sites where hematopoietic precursors travel to meet with specialized bone marrow stromal cells that provide lineage-specific signals necessary for their development and differentiation. Our laboratory is specifically interested in understanding the molecular mechanisms that regulate hematopoietic cell development, positioning and migration within bone marrow niches, and export into the periphery under normal homeostatic conditions. Our long-term goals are to understand at the molecular level how these mechanisms are regulated during changes in the environment such as inflammation, hormone imbalance, hypoxia, etc.