Arya Mani MD, FACC

Associate Professor of Medicine (Cardiology) and of Genetics; Director, Cardiovascular Genetics Program

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development

Yale Medical Group

Heart & Vascular Center, Yale-New Haven HospitalInternal Medicine: Cardiovascular Medicine: Cardiomyopathy Inherited Cardiovascular Disease Program, Echocardiography (Cardiac Imaging), Cardiovascular Genetics Program | Genetics

Research Interests

Identification of cardiovascular disorders that have strong familial pattern more...


  • M.D., Johannes-Gutenberg-University of Mainz, 1991

Selected Publications

  • 14. Singh, R, Smith, E, Fathzadeh, M, Liu, W, Faramarzi,S, Subrahmanyan, L, Go, GW, McKenna, W and Mani, Rare nonconservative LRP6 mutations are associated with metabolic syndrome. Human Mutation, 2013 PMID: 23703864
  • 13. (featured article) Singh R, De Aguiar RB, Naik S, Mani S, Ostadsharif K, Wencker D, Sotoudeh M, Malekzadeh R, Sherwin RS, Mani A. Lrp6 enhances glucose metabolism by promoting tcf7l2-dependent insulin receptor expression and igf receptor stabilization in humans. Cell Metab. 2013;17:197-209 PMC3589523
  • 12. Liu W, Singh R, Choi CS, Lee HY, Keramati AR, Samuel VT, Lifton RP, Shulman GI, Mani A. Low density lipoprotein (ldl) receptor-related protein 6 (lrp6) regulates body fat and glucose homeostasis by modulating nutrient sensing pathways and mitochondrial energy expenditure. J Biol Chem. 2012;287:7213-7223 PMC3293520



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