Vision Research at Yale

Yale scientists have always been at the forefront of vision research. Throughout the decades, the efforts of Yale researchers have led to many crucial discoveries, including:

  • Observations of Retinal Pigment Epithelium transdifferentiation (1950s)
  • Identification of cyclic GMP as an important photoreceptor messenger (1970s)
  • Preclinical development of Timolol (1970s)
  • Identification of the genes for Macular Degeneration (2005 and 2006)

It remains our mission to carry out groundbreaking research on the development, structure, and function of the visual system and uphold our position as a center of excellence. We take very seriously our obligation to translate these research findings into new treatments that can benefit those suffering from blinding eye diseases.

In addition, we provide a rigorous training environment for graduate students and postdoctoral fellows and serve as a center for a wide range of international collaborations.

Chen, Bo

Research Interests: Retinal degenerative diseases; Retinal neurobiology; Signal transduction pathways; Gene network regulation

    Coca-Prados, Miguel

    Research Interests: Chloride Channels of the ClC Family; Construction of Subtractive Libraries; Gene Expression and Regulation of Neuropeptides and Hormones; Gene Expression and Regulation of TIGR; Regulatory Peptides With Hypertensive And/or Hypotensive Act; Steroid Metabolism and Regulation of Gene Expression of 17bH

      Demb, Jonathan B.

      Research Interests: Neuroscience; Functional circuitry of the retina; Cellular basis of visual adaptation; Neural plasticity; Mechanisms of retinal disease

        Kim, In-Jung

        Research Interests: Neuroscience; Development; Visual system; Neural circuits; Transgenic approaches; Direction selectivity

        • Office: (203) 737-6926
        • Lab: (203) 737-6834

        Tsai, James C

        Research Interests: Molecules with the potential to protect the optic nerve from damage directly, without lowering intraocular pressure (e.g. neuroprotection); Evaluation of surgical outcomes in glaucoma patients; Development of advanced techniques of vision testing

        Clinical Interests: Diagnosis and management of challenging glaucoma cases including glaucoma implant surgery, trabeculectomy with antimetabolite surgery, and combined glaucoma and cataract surgery; sutureless cataract surgery in patients with glaucoma; eye disorders

        • Appt: (203) 785-2020

        Zhou, Z. Jimmy

        Research Interests: Physiology and development of the mammalian retina under normal and pathological conditions; Organization and function of retinal synapses and circuits

        • Office: (203) 785-2076
             

        Huang, John Jiqiang

        Research Interests: Vitreo-retinal diseases and uveitis; Pharmacogenomic treatment of macular degeneration patients; Quality of life in uveitis patients; External factors in treatment of diabetic retinopathy

        Clinical Interests: Non-infectious and infectious uveitis; retinal disorders; macular degeneration; diabetic retinopathy; macular hole; macular pucker; retinal detachment; cystoid macular edema; hereditary retinal degeneration; ocular lymphoma; ocular leukemia

        • Appt: (203) 785-2020

        Stoessel, Kathleen M

        Research Interests: Retinopathy of prematurity

        Clinical Interests: Evaluation and laser treatment of ROP and other adult and pediatric proliferative retinopathies, sickle cell retinopathy; retinal evaluation in pediatric head trauma; diabetic retinopathy; macular degeneration; retinal dystrophies

        • Office: (203) 785-2020
        • Appt: (203) 785-2020
             

        Crair, Michael C

        Research Interests: Neural circuit development; Synapse formation; Visual system development; Cortex development

        • Office: (203) 785-5768
        • Lab: (203) 785-6362

        Hoh, Josephine

        Research Interests: Interactions among genes; Environmental exposures

        • Office: (203) 785-2738
        • Lab: (203) 737-6007

        Rizzolo, Lawrence James

        Research Interests: Retinal disease; Tight junctions; Outer blood-retinal barrier; Epithelia; Human embryonic stem cells; Bio/tissue engineering; Medical education

        Clinical Interests: Medical education

        • Office: (203) 785-6277
        • Lab: (203) 785-6987

        Zeiss, Caroline J

        Research Interests: Molecular and cellular pathogenesis of retinal degeneration; Neurobiology of movement disorders; Phenotypes of genetically engineered mice; Evolutionary biology of the eye; Veterinary Pathology; Mouse Phenotyping; Ocular pathology with emphasis on photoreceptor disorders; Neuroanatomy of age-related gait disorders; Signal transduction events during neuronal death; Comparative pathology with emphasis on murine neuroanatomy; Phenotying genetically altered rodents

        • Office: (203) 737-4303

        Zenisek, David

        Research Interests: Physiology and cell biology of the presynaptic terminal; Retinal Bipolar Neuron; Synaptic Terminal; Synaptic Ribbons; Vesicle Transport; Exocytosis; Endocytosis

        • Office: (203) 785-6474