The Office of Multicultural Affairs (OMCA) was established in the School of Medicine by the Dean in September 1995 to expand the mission of the former Office of Minority Affairs. The OMCA was charged with task of developing resources and programs in support of all minority students and faculty at the School of Medicine. The Office is headed by the Assistant Dean for Multicultural Affairs, and a full-time Director.

The OMCA works with all racial/ethnic minorities, including the those minorities historically underrepresented minorities in the field of medicine. The programs of the office encompass a wide range of programs and activities for medical students, faculty, housestaff at Yale Medical Center, college students and graduates pursuing careers in biomedical science, and high school students in New Haven's regional science magnet high school. The OMCA administers programs funded by a combination of resources from the School of Medicine and grant-support from the National Institutes of Health, The Robert Wood Johnson Foundation, the Howard Hughes Medical Institute, and the Gustavus and Marie Pfeiffer Foundation.